A multi-pronged activation approach applied to 54 actinobacterial strains doubles accessible metabolite space and enables discovery of gram-negative bioactivity, offering insights to harness nature’s chemical potential. The approach enhances or triggers natural product production across all 54 native actinobacterial strains, doubling total metabolite production and enabling the discovery of a new tetramic acid analog with gram-negative bioactivity. Insights from this large-scale study could lead to a more streamlined approach to unlock the full potential of nature’s chemical resources.
- Dillon W. P. Tay
- Lee Ling Tan
- Fong Tian Wong
