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Showing 1–5 of 5 results

Advanced filters: Author: Deborah Finkel Clear advanced filters

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD

Lysosomes maintain RPE health via TFEB/E3-regulated autophagy. Here, the authors show deregulated AKT2/SIRT5/TFEB signaling in the RPE inhibits both lysosomal and mitochondrial function and leads to AMD, suggesting this pathway might provide a therapeutic target for AMD.

Sayan Ghosh
Ruchi Sharma
Debasish Sinha
ResearchOpen Access21 Jul 2024
Nature Communications

Volume: 15, P: 1-18
Dynamic correlation of apoptosis and immune activation during treatment of HIV infection

Andrew D Badley
Karl Parato
Jonathan B Angel
Research17 May 1999
Cell Death & Differentiation

Volume: 6, P: 420-432
Conversions between metabolically unhealthy and healthy obesity from midlife to late-life

Peggy Ler
Elsa Ojalehto
Ida K. Karlsson
ResearchOpen Access02 Dec 2023
International Journal of Obesity

Volume: 48, P: 433-436
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

This Perspective lays out the impetus and goals of the Cellular Senescence Network established to comprehensively identify and characterize senescent cells (SnCs) across tissues and lifespan, providing a publicly available SnC atlas.

Patty J. Lee
Christopher C. Benz
Mingyu Yang
Reviews20 Dec 2022
Nature Aging

Volume: 2, P: 1090-1100
Infantile onset Pompe disease: A report of physician narratives from an epidemiologic study

Deborah Marsden
Research01 Feb 2005
Genetics in Medicine

Volume: 7, P: 147-150