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Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters

Anne Tüngler
Sandra Van der Auwera
Deborah Janowitz
ResearchOpen Access20 Dec 2021
Scientific Reports

Volume: 11, P: 1-11
Sequence-based characterization of structural variation in the mouse genome

Binnaz Yalcin
Kim Wong
Jonathan Flint
Research14 Sept 2011
Nature

Volume: 477, P: 326-329
Genetic architecture of subcortical brain structures in 38,851 individuals

Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways.

Claudia L. Satizabal
Hieab H. H. Adams
M. Arfan Ikram
Research21 Oct 2019
Nature Genetics

Volume: 51, P: 1624-1636
Novel genetic loci associated with hippocampal volume

The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

Derrek P. Hibar
Hieab H. H. Adams
M. Arfan Ikram
ResearchOpen Access18 Jan 2017
Nature Communications

Volume: 8, P: 1-12
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Novel genetic loci underlying human intracranial volume identified through genome-wide association

In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

Hieab H H Adams
Derrek P Hibar
Paul M Thompson
Research03 Oct 2016
Nature Neuroscience

Volume: 19, P: 1569-1582
Mouse genomic variation and its effect on phenotypes and gene regulation

Thomas M. Keane
Leo Goodstadt
David J. Adams
ResearchOpen Access14 Sept 2011
Nature

Volume: 477, P: 289-294
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Association between serum neuron-specific enolase, age, overweight, and structural MRI patterns in 901 subjects

Johanna Hoffmann
Deborah Janowitz
Hans Jörgen Grabe
ResearchOpen Access08 Dec 2017
Translational Psychiatry

Volume: 7, P: 1-9
Common genetic variants influence human subcortical brain structures

Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes of variability in brain development and may help to determine mechanisms of neuropsychiatric dysfunction.

Derrek P. Hibar
Jason L. Stein
Sarah E. Medland
Research21 Jan 2015
Nature

Volume: 520, P: 224-229
Brain-derived neurotrophic factor is related with adverse cardiac remodeling and high NTproBNP

Martin Bahls
Stephanie Könemann
Marcus Dörr
ResearchOpen Access28 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Pleasurable and problematic receptive anal intercourse and diseases of the colon, rectum and anus

Receptive anal intercourse (RAI) is an important consideration in gastrointestinal disorders and cancers. This Review discusses the anorectum as a sexual organ, providing an overview of pleasurable and problematic RAI and how gastrointestinal disease itself and associated treatments (such as surgery) can affect RAI. Strategies to manage problematic RAI to improve sexual health are also described.

Daniel R. Dickstein
Collin R. Edwards
Deborah C. Marshall
Reviews19 May 2024
Nature Reviews Gastroenterology & Hepatology

Volume: 21, P: 377-405
Vitamin D moderates the interaction between 5-HTTLPR and childhood abuse in depressive disorders

Sarah Bonk
Johannes Hertel
Hans Jörgen Grabe
ResearchOpen Access28 Dec 2020
Scientific Reports

Volume: 10, P: 1-9

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