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Scientific Reports (27)
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Showing 1–50 of 57 results

Advanced filters: Author: Dejun Li Clear advanced filters

Pore size distributions and fractal characteristics of basalt fiber-reinforced coral sand concrete

Xiaoyan Zhang
Lingfeng Meng
Kaiyuan Wei
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
ClickGen: Directed exploration of synthesizable chemical space via modular reactions and reinforcement learning

Generative models face challenges with low synthesizability of generated molecules. Here, authors develop ClickGen, a deep learning model using modular reactions and reinforcement learning to generate highly diverse, novel, and synthesizable molecules

Mingyang Wang
Shuai Li
Chang-Yu Hsieh
ResearchOpen Access22 Nov 2024
Nature Communications

Volume: 15, P: 1-18
The gut ileal mucosal virome is disturbed in patients with Crohn’s disease and exacerbates intestinal inflammation in mice

Gut bacteriome dysbiosis has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Here, they authors characterize the small bowel (terminal ileum) virome and bacteriome of patients with Crohn´s Disease (CD), and show that ileal virions from CD patients causally exacerbate intestinal inflammation in IBD mouse models.

Zhirui Cao
Dejun Fan
Tao Zuo
ResearchOpen Access22 Feb 2024
Nature Communications

Volume: 15, P: 1-22
Leveraging language model for advanced multiproperty molecular optimization via prompt engineering

Designing molecules in drug design is challenging as it requires optimizing multiple, potentially competing qualities. Wu and colleagues present a prompt-based molecule optimization method that can be trained from single-property data.

Zhenxing Wu
Odin Zhang
Tingjun Hou
Research21 Oct 2024
Nature Machine Intelligence

Volume: 6, P: 1359-1369
Diagnostic evaluation of a deep learning model for optical diagnosis of colorectal cancer

Colonoscopy is the most commonly used tool to screen for colorectal cancer (CRC). Here, the authors develop a deep learning model to perform optical diagnosis of CRC by training on a large data set of white-light colonoscopy images and achieve endoscopist-level performance on three independent datasets.

Dejun Zhou
Fei Tian
Xiangchun Li
ResearchOpen Access11 Jun 2020
Nature Communications

Volume: 11, P: 1-9
Regulatory T cells crosstalk with tumor cells and endothelium through lymphotoxin signaling

The lymphotoxin (LT) system has several defined roles in the regulation of immunity as well as vascular and lymphatic biology, however its role in cancer is less understood. Here the authors show that regulatory T cell-derived LTα1β2 promotes LTβ receptor-nonclassical NFκB signaling in tumor cells and lymphatic endothelial cells, accelerating tumor growth and metastasis.

Wenji Piao
Long Wu
Jonathan S. Bromberg
ResearchOpen Access02 Dec 2024
Nature Communications

Volume: 15, P: 1-18
Allelic variation of TaWD40-4B.1 contributes to drought tolerance by modulating catalase activity in wheat

Drought stress limits wheat production around the world. Here, the authors report allelic variation of a WD40 encoding gene TaWD40-4B.1 contributes to wheat drought tolerance by interacting with canonical catalases as a chaperone to promote their activities to avoid ROS over accumulation.

Geng Tian
Shubin Wang
Mengcheng Wang
ResearchOpen Access02 Mar 2023
Nature Communications

Volume: 14, P: 1-18
Variation in TaSPL6-D confers salinity tolerance in bread wheat by activating TaHKT1;5-D while preserving yield-related traits

The study identifies TaSPL6-D as a negative regulator of TaHKT1;5-D and salinity tolerance in bread wheat. An insertion variation of TaSPL6-D, mainly hidden in landraces, shows the potential for breeding salt-tolerant crops.

Meng Wang
Jie Cheng
Weiming Shi
Research27 May 2024
Nature Genetics

Volume: 56, P: 1257-1269
Gene-informed decomposition model predicts lower soil carbon loss due to persistent microbial adaptation to warming

Mechanisms and consequences of the acclimation of soil respiration to warming are unclear. Here, the authors combine soil respiration, metagenomics, and functional gene results from a 7-year grassland warming experiment to a microbial-enzyme decomposition model, showing functional gene information to lower uncertainty and improve fit.

Xue Guo
Qun Gao
Jizhong Zhou
ResearchOpen Access29 Sept 2020
Nature Communications

Volume: 11, P: 1-12
An adaptive graph learning method for automated molecular interactions and properties predictions

Deep learning methods can provide useful predictions for drug design, but their hyperparameters need to be carefully tweaked to give good performance on a specific problem or dataset. Li et al. present here a method that finds appropriate architectures and hyperparameters for a wide range of drug design tasks and can achieve good performance without human intervention.

Yuquan Li
Chang-Yu Hsieh
Xiaojun Yao
Research23 Jun 2022
Nature Machine Intelligence

Volume: 4, P: 645-651
Multi-modal deep learning enables efficient and accurate annotation of enzymatic active sites

Wang et al. propose EasIFA, an efficient enzyme active site annotation algorithm, to advance various fields including drug discovery, disease research, enzyme engineering, and synthetic biology.

Xiaorui Wang
Xiaodan Yin
Chang-Yu Hsieh
ResearchOpen Access27 Aug 2024
Nature Communications

Volume: 15, P: 1-20
Research on the dynamic performance and motion control methods of deep-sea human occupied vehicles

Dejun Li
Qiaosheng Zhao
Xinbei Lv
ResearchOpen Access17 Feb 2025
Scientific Reports

Volume: 15, P: 1-23
Exploring the spatial patterns and influencing factors of rural tourism development in Hainan Province of China

Xiao Kun
Wahid Ullah
Wang Ziyun
ResearchOpen Access10 Jan 2025
Scientific Reports

Volume: 15, P: 1-21
Multi-constraint molecular generation based on conditional transformer, knowledge distillation and reinforcement learning

Combining generative models and reinforcement learning has become a promising direction for computational drug design, but it is challenging to train an efficient model that produces candidate molecules with high diversity. Jike Wang and colleagues present a method, using knowledge distillation, to condense a conditional transformer model to make it usable in reinforcement learning while still generating diverse molecules that optimize multiple molecular properties.

Jike Wang
Chang-Yu Hsieh
Tingjun Hou
Research18 Oct 2021
Nature Machine Intelligence

Volume: 3, P: 914-922
Retention of deposited ammonium and nitrate and its impact on the global forest carbon sink

A study using paired ¹⁵N tracers shows atmospheric N deposited in oxidized form is more likely retained by trees, while the reduced form is retained in soil. The authors argue that this is a greater contribution of deposited N to the global forest C sink than previously reported.

Geshere Abdisa Gurmesa
Ang Wang
Yunting Fang
ResearchOpen Access15 Feb 2022
Nature Communications

Volume: 13, P: 1-9
Chemistry-intuitive explanation of graph neural networks for molecular property prediction with substructure masking

Attempts to explain molecular property predictions of neural networks are not always compatible with chemical intuition based on chemical substructures. Here the authors propose the substructure mask explanation method to tackle this challenge.

Zhenxing Wu
Jike Wang
Tingjun Hou
ResearchOpen Access04 May 2023
Nature Communications

Volume: 14, P: 1-15
The rubber tree genome reveals new insights into rubber production and species adaptation

A high-quality rubber tree genome reveals insights into the evolution of rubber biosynthesis and ethylene stimulation in rubber production. Together with transcriptome data, this study provides valuable data for the research and breeding of rubber trees.

Chaorong Tang
Meng Yang
Huasun Huang
ResearchOpen Access23 May 2016
Nature Plants

Volume: 2, P: 1-10
Long non-coding RNA expression patterns in lung tissues of chronic cigarette smoke induced COPD mouse model

Haiyun Zhang
Dejun Sun
Wenju Lu
ResearchOpen Access15 May 2018
Scientific Reports

Volume: 8, P: 1-14
Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans

Mobile tet(X3) and tet(X4) genes are identified on conjugative plasmids in Enterobacteriaceae and Acinetobacter isolated from humans, meat for consumption and animals that confer resistance to tetracyclines, including tigecycline, eravacycline and omadacycline.

Tao He
Ran Wang
Yang Wang
Research27 May 2019
Nature Microbiology

Volume: 4, P: 1450-1456
Molecular diagnose of a large hearing loss population from China by targeted genome sequencing

Jie Wu
Zongfu Cao
Pu Dai
ResearchOpen Access19 Aug 2022
Journal of Human Genetics

Volume: 67, P: 643-649
Soil organic carbon accumulation during post-agricultural succession in a karst area, southwest China

Liqiong Yang
Pan Luo
Dejun Li
ResearchOpen Access23 Nov 2016
Scientific Reports

Volume: 6, P: 1-8
Increasing TRPV4 expression restores flow-induced dilation impaired in mesenteric arteries with aging

Juan Du
Xia Wang
Bing Shen
ResearchOpen Access07 Mar 2016
Scientific Reports

Volume: 6, P: 1-11
Tanshinone IIA sulfonate protects against cigarette smoke-induced COPD and down-regulation of CFTR in mice

Defu Li
Jian Wang
Wenju Lu
ResearchOpen Access10 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
Anti-hyperglycemic and anti-hyperlipidemia effects of the alkaloid-rich extract from barks of Litsea glutinosa in ob/ob mice

Xiaopo Zhang
Yan Jin
Youbin Li
ResearchOpen Access23 Aug 2018
Scientific Reports

Volume: 8, P: 1-10
Enhanced or Weakened Western North Pacific Subtropical High under Global Warming?

Chao He
Tianjun Zhou
Bin Zheng
ResearchOpen Access26 Nov 2015
Scientific Reports

Volume: 5, P: 1-7
Carbon: nitrogen stoichiometry following afforestation: a global synthesis

Xia Xu
Dejun Li
Yiqi Luo
ResearchOpen Access08 Jan 2016
Scientific Reports

Volume: 6, P: 1-8
Ultra-tough light-curing ionogels for UV shielding

Polyurethane ionogels can be made with UV light curing but suffer from low mechanical properties compared to conventional polyurethane. Here, robust UV light curable ionogels are made by using prepolymers containing carbon-carbon double bonds as monomers which cross-links to form entangled polymer networks.

Zeyu Zhang
Dejun Peng
Shujun Li
ResearchOpen Access30 Nov 2024
Communications Materials

Volume: 5, P: 1-12
Remote sensing image dehazing using a wavelet-based generative adversarial networks

Guangda Chen
Yanfei Jia
Tenghao Wang
ResearchOpen Access29 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
Soil nitric oxide emissions from terrestrial ecosystems in China: a synthesis of modeling and measurements

Yong Huang
Dejun Li
ResearchOpen Access10 Dec 2014
Scientific Reports

Volume: 4, P: 1-8
Transcriptome analyses reveal molecular mechanism underlying tapping panel dryness of rubber tree (Hevea brasiliensis)

Dejun Li
Xuncheng Wang
Guangming He
ResearchOpen Access23 Mar 2016
Scientific Reports

Volume: 6, P: 1-10
ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner

Rongkun Li
Qian Ji
Hengchao Li
Research17 Dec 2024
Cancer Gene Therapy

Volume: 32, P: 240-253
Contribution of social and lifestyle factors to cognitive status and 5-year change among middle-aged and older Americans

Ming Wen
Hui Zheng
Dejun Su
ResearchOpen Access15 Feb 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-10
Study on the destruction law of physical and shear properties of soil in mining disturbance

Qiya Qiao
Guangming Shi
Xue-er Bai
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-17
Gene expression analysis and SNP/InDel discovery to investigate yield heterosis of two rubber tree F1 hybrids

Dejun Li
Rizhong Zeng
Chengzhi Liang
ResearchOpen Access25 Apr 2016
Scientific Reports

Volume: 6, P: 1-12
A phosphate starvation induced small RNA promotes Bacillus biofilm formation

Yulong Li
Xianming Cao
Ben Fan
ResearchOpen Access29 Oct 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-12
Identification of novel autophagy-related lncRNAs associated with a poor prognosis of colon adenocarcinoma through bioinformatics analysis

Dejun Wu
Zhenhua Yin
Ming Xu
ResearchOpen Access13 Apr 2021
Scientific Reports

Volume: 11, P: 1-12
Tim-3 inhibits macrophage control of Listeria monocytogenes by inhibiting Nrf2

Zhiding Wang
Dejun Sun
Gencheng Han
ResearchOpen Access16 Feb 2017
Scientific Reports

Volume: 7, P: 1-14
Author Correction: Long non-coding RNA expression patterns in lung tissues of chronic cigarette smoke induced COPD mouse model

Haiyun Zhang
Dejun Sun
Wenju Lu
Amendments and CorrectionsOpen Access09 May 2019
Scientific Reports

Volume: 9, P: 1
Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness

Rongkun Li
Hengchao Li
Shu-Heng Jiang
ResearchOpen Access26 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-14
Assessing children’s potential exposures to harmful metals in tire crumb rubber by accelerated photodegradation weathering

Robyn Winz
Lee L. Yu
Dejun Chen
ResearchOpen Access24 Aug 2023
Scientific Reports

Volume: 13, P: 1-10
A study on the DAM-EfficientNet hail rapid identification algorithm based on FY-4A_AGRI

Renfeng Liu
Haonan Dai
Cheng Zhou
ResearchOpen Access12 Feb 2024
Scientific Reports

Volume: 14, P: 1-15
Weighted gene co-expression network analysis reveals genes related to growth performance in Hu sheep

Qiang Wang
Jie Xu
Yongjun Li
ResearchOpen Access06 Jun 2024
Scientific Reports

Volume: 14, P: 1-12
Dynamics of aggregate-associated organic carbon after long-term cropland conversion in a karst region, southwest China

Li Wen
Dejun Li
Xiaoping Xiao
ResearchOpen Access31 Jan 2023
Scientific Reports

Volume: 13, P: 1-12
3D-printing process design of lattice compressor impeller based on residual stress and deformation

JIA Dejun
LI Fanchun
Yuan ZHANG
ResearchOpen Access17 Jan 2020
Scientific Reports

Volume: 10, P: 1-11
Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1

Yongsheng Jiang
Ruizhe He
Yongwei Sun
ResearchOpen Access11 Dec 2019
Cell Death & Disease

Volume: 10, P: 1-13
Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway

Xiangdong Tian
Dejun Zhou
Qiang Zhao
ResearchOpen Access19 Jan 2018
Cell Death & Disease

Volume: 9, P: 1-14
Construction of a novel signature and prediction of the immune landscape in gastric cancer based on necroptosis-related genes

Zhengtian Li
Wenkang Yang
Xi Li
ResearchOpen Access02 Aug 2022
Scientific Reports

Volume: 12, P: 1-19
The potential utility of hybrid photo-crosslinked hydrogels with non-immunogenic component for cartilage repair

Yili Wang
Levinus Hendrik Koole
Huaqiong Li
ResearchOpen Access10 Sept 2021
npj Regenerative Medicine

Volume: 6, P: 1-14
Author Correction: The potential utility of hybrid photo-crosslinked hydrogels with non-immunogenic component for cartilage repair

Yili Wang
Levinus Hendrik Koole
Huaqiong Li
Amendments and CorrectionsOpen Access20 Dec 2022
npj Regenerative Medicine

Volume: 7, P: 1-3
Genomic epidemiology of animal-derived tigecycline-resistant Escherichia coli across China reveals recent endemic plasmid-encoded tet(X4) gene

Sun et al. analyse E. coli strains from pigs and chickens in Chinese farms and slaughterhouses, and reveal that while the tet(X4) gene is not ubiquitous across China, it is highly endemic in northwestern China. Genomic analysis of these strains shows recent and independent acquisitions of plasmids in across regions.

Chengtao Sun
Mingquan Cui
Yang Wang
ResearchOpen Access31 Jul 2020
Communications Biology

Volume: 3, P: 1-10

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