Search

Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

A thin-film engineering method is employed to preserve high pressure solids in diamond capsules at ambient conditions, enabling tunable preserved pressures, controllable particle size, atomic-scale characterization, and potential large-scale uses.

Hydrogel materials have emerged as versatile platforms for biomedical applications. Here this group reports an mRNA lipid nanoparticle-incorporated microgel matrix for immune cell recruitment/antigen expression and presentation/cellular interaction thereby eliciting antitumor efficacy with a single dose.

The Fermi-LAT Collaboration reports a significant γ-ray detection (5.2σ) from the coronae of radio-quiet active galactic nuclei, revealing compact (~10 gravitational radii) and extended (~2.7 × 10⁶ gravitational radii) corona regions, challenging existing models.

Tomonaga-Luttinger liquid behavior has been observed within 1D defects in transition metal dichalcogenides. Here, using complementary experiments and engineered defects, the authors demonstrate the importance of graphene as a substrate and its role in the formation of this quasiparticle excitation in 2D WS₂.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The coupling of ferroelectricity and magnetic order enables the tunability of material properties. Here, authors realize magnetic-field-enhanced ferroelectricity and electrical-field-controlled magneto-transport in non-magnetic moiré superlattices.

Here, authors leverage two uncoupled, independently tuned resonators to achieve broadband (> 100 nm) resonant second-harmonic generation across the entire telecom spectrum.

Craniofacial development and structure in early Pleistocene Homo is unclear due to a lack of well-preserved specimens. Here, the authors examine infant craniofacial fossils from eastern and southern Africa to demonstrate that taxonomic diversity in early Homo is already present very early in life.

Tumor-associated macrophages are pivotal in control over solid tumors. Here the authors show that these macrophages express chemosensors that detect lipid variants in the tumor microenvironment that can regulate the function of these cells.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Domesticated grapevine produces hermaphroditic flowers, while other Vitis species are dioecious. The authors report that the Vitis sex-determining region contains flowering-related genes conserved across angiosperms and the Vitaceae, and propose a model for the evolution of dioecy in Vitis and Muscadinia.

Genome-wide sequencing of 180 ancient individuals shows a continuous gradient of ancestry in Early-to-Mid-Holocene hunter-gatherers from the Baltic to the Transbaikal region and distinct contemporaneous groups in Northeast Siberia, and provides insights into the origins of modern Uralic and Yeniseian speakers.

Metabolic processes lead to the production of bioactive gases, such as nitric oxide, which may play roles in the gut immune homeostasis. Here authors show that genomic deletion of Nos2 in mice aggravates colitis in experimental models via an Aryl-Hydrocarbon-Receptor-mediated pathway in type 3 innate lymphoid cells.

Radiation-induced liver damage is an important side-effect of radiation as a cancer therapy. Here, the authors identify pyroptosis protein gasdermin D as a key driver of liver injury and a potential therapeutic target to alleviate this damage.

Here, the authors identify EZH2-mediated DDX1 K234 methylation as a driver of MATR3 mis-splicing, leading to senescence and apoptosis of NP cells, and propose lipid nanoparticle-based delivery of full-length MATR3 as a potential therapy for IVDD.

Literature produced inconsistent findings regarding the links between extreme weather events and climate policy support across regions, populations and events. This global study offers a holistic assessment of these relationships and highlights the role of subjective attribution.

Tests of the predictions of the renormalization group in biological experiments have not yet been decisive. Now, a study on the collective dynamics of insect swarms provides a long-sought match between experiment and theory.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

An unconventional machine learning-based inverse design framework enables the generation of ultrabroadband and band-selective thermal meta-emitters with complex 3D architectures and diverse material compositions.

c-di-AMP is essential for bacterial signaling. Here, the authors identify the GlcNAc-sensing regulator DasR as a c-di-AMP receptor and provide molecular insight into their signaling effect on the developmental and antibiotic biosynthesis control across Actinobacteria.

A fuzzy sequencer can exceed the current limit of information efficiency of DNA sequencers for resequencing applications.

This study employs a functional genomic approach to identify a synthetic lethal interaction between CDS1 and CDS2 in uveal melanoma and other cancers, which may represent a potential therapeutic target.

Rehmannia chingii is a traditional Chinese medicinal plant that can produce iridoid glycoside. Here, the authors report its genome assembly and the elucidation of the iridoid biosynthetic pathway.

The mantle upwelling beneath the Afar rift may be influenced by tectonic processes in the overriding lithospheric plates that shape the distribution of both the compositional heterogeneities and abundance of melt, according to a geochemical and statistical study of volcanic samples.

Employing appropriate catalysts in room-temperature sodium-sulfur batteries can significantly enhance performance. Here, authors utilize natural language processing techniques in conjunction with a binary descriptor to screen preferrable single-atom catalysts to achieve high specific capacity.

The color of rhodopsins is regulated by the interaction of the chromophore with its counterion. Here the authors introduce a computational model showing that color tuning can be described in terms of virtual counterion migration and delocalization pathways.

Shi and colleagues present a spatial microfluidic holographic integrated platform for label-free, high-dimensional analysis of cancer heterogeneity, achieving very high accuracy in classifying cancer types, breast cancer subtypes, and blood cells.

Yang et al. report a flexible polarization-sensitive optoelectronic synapse array based on oriented and anisotropic PEA₂SnI₄ nanowires. 16 encoded states are employed for in-sensor reservoir computing to enable 100% accuracy in dynamic trace extraction under complex light conditions.

The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regress, a process that is associated with a reduction in neuronal activity.

This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

Here the authors show that CD4⁺ effector T cells prevent or reverse CD8⁺ T cell dysfunction by licensing Kupffer cells to trigger IL-27 production, defining a liver-specific immune circuit and a potential target for chronic HBV therapeutics.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Qifa Zhang and colleagues report the map-based cloning of the quantitative trait locus GS5, which regulates grain size and yield in rice. GS5 encodes a putative serine carboxypeptidase and increased expression is associated with larger grain.

Borcoman and colleagues present the efficacy and safety results of the phase 2 PEVOsq basket trial investigating the combination of pembrolizumab with the epidrug vorinostat in patients with recurrent and/or metastatic squamous cell carcinoma.

Post-translational modifications (PTMs) regulate protein homeostasis and function. Here, the authors applied mass spectrometry to uncover extensive changes in protein ubiquitylation in the aging mouse brain and show that dietary intervention can alter protein ubiquitylation in old mice.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

A reconstruction method for image scanning microscopy exploits all the information encoded in the four-dimensional image scanning microscopy dataset to achieve optical sectioning and maintain super-resolution and high-signal-to-noise-ratio imaging.

Attosecond transient reflection spectroscopy is used to experimentally observe the attosecond electron dynamics of a crystalline diamond, showing that virtual interband transitions affect the timing and adiabaticity of the crystal response and thus providing insights for the development of information processing and petahertz electronics.

Solution-based methods exist to upcycle waste polyolefins, although these resort to the use of co-reactants and require non-negligible energy inputs. Here the authors show how a solar thermal catalytic system based on copper particles encapsulated within a 2D Si material can strongly alleviate such issues.

Here, the authors show how HSV-1 rewires the host cell’s chromatin architecture during lytic infection by hijacking transcription machinery and forming contacts between viral and host genomes.

Gapless modes emerging from non-equilibrium phase transitions are predicted to diffuse rather than propagate as sound waves. Now, the diffusion of these modes and their suppression under symmetry breaking are confirmed in a polariton condensate.