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Showing 51–71 of 71 results
Advanced filters: Author: Diane Mathis Clear advanced filters

  • As part of the Immunogical Genome project, Kang and colleagues compare the gene-expression profiles of emergent thymocytes from adult mice that express the γδ T cell antigen receptor, segregated on the basis of the use of the γ- or δ-chain variable region, and find that the main subsets are molecularly distinct.

    • Kavitha Narayan
    • Katelyn E Sylvia
    • Christophe Benoist
    Research
    Nature Immunology
    Volume: 13, P: 511-518

  • Recent studies have highlighted the diversity and distinct nature of regulatory T cells in the intestine, where they must balance a multitude of signals from the microbiota and the diet to ensure immune homeostasis. But questions and controversies remain over their origins and regulation, as discussed here.

    • Deepshika Ramanan
    • Alvin Pratama
    • Christophe Benoist
    Reviews
    Nature Reviews Immunology
    Volume: 23, P: 749-762

  • Nature Immunology’s 20th anniversary is a good opportunity to reminisce about the ImmGen collective endeavor — its goals, successes and horror stories — and the group’s exploration of various modes of scientific publishing.

    • Stephanie Vargas Aguilar
    • Oscar Aguilar
    • Caroline Ziemkiewicz
    Comments & Opinion
    Nature Immunology
    Volume: 21, P: 700-703

  • Brown and colleagues generated an atlas of miRNA expression profiles from primary mouse immune cell populations and connected these signatures with ATAC–seq, ChIP–seq and nascent RNA profiles to establish a map of miRNA promoter and enhancer usage in immune cells.

    • Samuel A. Rose
    • Aleksandra Wroblewska
    • Aldrin Yim
    Research
    Nature Immunology
    Volume: 22, P: 914-927

  • Regulatory T cells present in non-lymphoid tissues such as the skin, fat and muscle are distinct from their counterparts in lymphoid tissues. Their functions extend beyond immune surveillance to the control of local metabolism, tissue repair and tissue cell progenitors, as discussed in this Review.

    • Andrés R. Muñoz-Rojas
    • Diane Mathis
    Reviews
    Nature Reviews Immunology
    Volume: 21, P: 597-611

  • Lanier and colleagues systematically define the transcriptome of mouse natural killer cells in several contexts, including activation states and relative to all other lymphocyte and myeloid populations profiled by the Immunological Genome Project consortium.

    • Natalie A Bezman
    • Charles C Kim
    • Christophe Benoist
    Research
    Nature Immunology
    Volume: 13, P: 1000-1009

  • The transcriptional regulation of commitment to the dendritic cell (DC) lineage and functional specialization of DCs in vivo is poorly understood. In this Resource, Merad and colleagues identify the lineage relationships among various tissue DC subsets.

    • Jennifer C Miller
    • Brian D Brown
    • Christophe Benoist
    Research
    Nature Immunology
    Volume: 13, P: 888-899

  • This article discusses the current models of how ligation of inhibitory receptors on NK cells by host MHC class I molecules can result in 'educated' NK cells and the recent insights into the signalling pathways that are involved. How MHC class I molecules can regulate receptor repertoire formation in NK cells is also discussed.

    • Petter Höglund
    • Petter Brodin
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 724-734

  • The transcriptional circuitry that controls the differentiation of hematopoietic stem cells into cells of the immune system is only partially understood. Koller and colleagues use a computational algorithm to identify previously unknown differentiation stage–specific regulators of mouse hematopoiesis.

    • Vladimir Jojic
    • Tal Shay
    • Shannon Turley
    Research
    Nature Immunology
    Volume: 14, P: 633-643

  • This Review explores how distinct antigen-presenting cell types that reside in lymph nodes can contribute to T cell activation. The authors discuss the recent evidence showing that lymph node stromal cell populations are involved in the maintenance of peripheral immune tolerance.

    • Shannon J. Turley
    • Anne L. Fletcher
    • Kutlu G. Elpek
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 813-825