Communication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily health. Ageing leads to a decline in this complex communication network to the detriment of these daily homeostatic rhythms. This Review discusses clock communication pathways in the healthy versus aged state and explores the potential of modulating these communication pathways to slow circadian rhythm decline with ageing.
- Thomas Mortimer
- Jacob G. Smith
- Salvador Aznar Benitah
