Nature Search

Copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of 1,3-enynes and azomethine ylides

One of the most efficient method to access chiral poly-substituted pyrrolidines is the catalytic asymmetric 1,3-dipolar cycloaddition, but using this reaction with weakly activated alkenes remains elusive. Here, the authors disclose a copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides and 1,3-enynes.

Bo-Ran Wang
Yan-Bo Li
Liang Yin
ResearchOpen Access04 Aug 2023
Nature Communications

Volume: 14, P: 1-11
Cas12e orthologs evolve variable structural elements to facilitate dsDNA cleavage

CRISPR-Cas12e systems exhibit robust genome editing capabilities, yet their phylogenetic diversity remains underexplored. Here, authors elucidate the biochemical diversity and structural variations of newly identified Cas12e proteins, offering critical insights into structure-activity relationships.

Danyuan Li
Shouyue Zhang
Jun-Jie Gogo Liu
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-14
Study on mining deformation and fracture response mechanism and rock pressure law of super thick composite key roof

Wulin Lei
Yuanjia Shang
Xuanhong Du
ResearchOpen Access30 May 2025
Scientific Reports

Volume: 15, P: 1-12
Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies

Butterflies are a promising system to study the genetics and evolution of morphological diversification, yet genomic and technological resources are limited. Here, the authors sequence genomes of two Papiliobutterflies and develop a CRISPR/Cas9 gene editing method for these species.

Xueyan Li
Dingding Fan
Wen Wang
ResearchOpen Access10 Sept 2015
Nature Communications

Volume: 6, P: 1-10
PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes

Blocking the mechanical sensor PIEZO1 in cytotoxic T lymphocytes strengthens their traction forces and augments their cytotoxicity against tumour cells.

Ruiyang Pang
Weihao Sun
Yuying Liu
Research21 Mar 2024
Nature Biomedical Engineering

Volume: 8, P: 1162-1176
Sea cucumbers and their symbiotic microbiome have evolved to feed on seabed sediments

Sea cucumbers are predominant deposit feeders in benthic ecosystems. This study elucidates the mechanisms within the sea cucumber digestive system and their symbiotic microbiome which enable them to efficiently utilize nutrients from seabed sediments.

Wenjie Pan
Xuan Wang
Ting Chen
ResearchOpen Access12 Oct 2024
Nature Communications

Volume: 15, P: 1-14
The oyster genome reveals stress adaptation and complexity of shell formation

The sequencing and assembly of the highly polymorphic oyster genome through a combination of short reads and fosmid pooling, complemented with extensive transcriptome analysis of development and stress response and proteome analysis of the shell, provides new insight into oyster biology and adaptation to a highly changeable environment.

Guofan Zhang
Xiaodong Fang
Jun Wang
ResearchOpen Access19 Sept 2012
Nature

Volume: 490, P: 49-54
Experimental study on dynamic evolutions of airflow in the ventilation network under the effect of mine gas outburst disasters

Jingxiao Yu
ZongXiang Li
Shuhao Fang
ResearchOpen Access27 Mar 2025
Scientific Reports

Volume: 15, P: 1-15
Photovoltaic nanocells for high-performance large-scale-integrated organic phototransistors

This work reports core–shell photovoltaic nanocells to enhance the photoresponse of the active layer and realize photolithographic manufacturing of large-scale-integrated organic phototransistors for high-resolution biomimetic vision.

Shen Zhang
Renzhong Chen
Dacheng Wei
Research04 Jul 2024
Nature Nanotechnology

Volume: 19, P: 1323-1332
Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls

The authors perform a genome-wide association study of adolescent idiopathic scoliosis patients of Han Chinese descent, and identify 3 new loci for disease susceptibility.

Zezhang Zhu
Nelson Leung-Sang Tang
Jack Chun-Yiu Cheng
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-6
Research on stress release and pressure relief mechanism of underlying coal and rock under protective layer mining

Wulin Lei
Jing Chai
Yongchun Gong
ResearchOpen Access15 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Small reorganization energy acceptors enable low energy losses in non-fullerene organic solar cells

Minimising energy loss is important for achieving high-performance organic solar cells. Here, the authors design and synthesise two acceptors with small reorganisation energies and reveal the relationship between reorganisation energy and energy losses.

Yanan Shi
Yilin Chang
Zhixiang Wei
ResearchOpen Access07 Jun 2022
Nature Communications

Volume: 13, P: 1-10
Whole-exome Sequencing Analysis Identifies Mutations in the EYS Gene in Retinitis Pigmentosa in the Indian Population

Yanan Di
Lulin Huang
Zhenglin Yang
ResearchOpen Access20 Jan 2016
Scientific Reports

Volume: 6, P: 1-10
Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients

Immune cell changes are associated with Kawasaki disease (KD) pathogenesis. Here, using single cell RNA sequencing of PBMC, the authors show monocyte inflammatory genes are over-expressed in KD and TCR and BCR clonotype sequences show oligoclonal expansions after intravenous immunoglobulin therapy.

Zhen Wang
Lijian Xie
Min Huang
ResearchOpen Access14 Sept 2021
Nature Communications

Volume: 12, P: 1-10
The locust genome provides insight into swarm formation and long-distance flight

Locusts are destructive agricultural pests and serve as a model organism for studies of insects. Here, the authors report a draft genome sequence of the migratory locust, Locusta migratoria, and provide insight into genes associated with key survival traits such as phase-change, long-distance migration and feeding.

Xianhui Wang
Xiaodong Fang
Le Kang
ResearchOpen Access14 Jan 2014
Nature Communications

Volume: 5, P: 1-9
Chromosome-level genome assembly and annotation of the tropical sea cucumber Stichopus monotuberculatus

Ting Chen
Yun Yang
Chaoqun Hu
ResearchOpen Access18 Nov 2024
Scientific Data

Volume: 11, P: 1-12
Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity

Conjugates of small-molecule anticancer drugs with a polyzwitterion that has negligible interaction with proteins and a weak interaction with phospholipids eradicate large tumours and patient-derived tumour xenografts in mice.

Siqin Chen
Yin Zhong
Youqing Shen
Research15 Apr 2021
Nature Biomedical Engineering

Volume: 5, P: 1019-1037
Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii

Bats account for 20 per cent of all mammals, these are the only mammals with powered flight, and are among the few animals that echolocate. Here, Seim et al. sequence the genome of the long-lived (>40 years) Brandt’s bat, Myotis brandtiiand provide clues to its evolution, longevity and other traits.

Inge Seim
Xiaodong Fang
Vadim N. Gladyshev
ResearchOpen Access20 Aug 2013
Nature Communications

Volume: 4, P: 1-8
Flexible ceramic nanofibrous sponges with hierarchically entangled graphene networks enable noise absorption

Noise pollution has been a burden to the global economy, environment, and human health. Here the authors demonstrate a facile route to produce flexible ceramic nanofibrous sponges with hierarchically entangled graphene networks and its excellent noise absorption properties at elevated temperatures.

Dingding Zong
Leitao Cao
Bin Ding
ResearchOpen Access15 Nov 2021
Nature Communications

Volume: 12, P: 1-11
Facet effect of hematite on the hydrolysis of phthalate esters under ambient humidity conditions

With a combined experimental and computational study, Jin et al. demonstrate that hematite nanoparticles can efficiently degrade phthalates under ambient humidity conditions, with a rate strongly dependent on the exposed facet via bidentate coordination involving neighbor Fe atoms, suggesting their possible use for indoor air purification

Xin Jin
Dingding Wu
Cheng Gu
ResearchOpen Access17 Oct 2022
Nature Communications

Volume: 13, P: 1-11
Improving access to cardiovascular care for 1.4 billion people in China using telehealth

Xiaohang Liu
Wei Chen
Jeffrey Hsu
ResearchOpen Access23 Dec 2024
npj Digital Medicine

Volume: 7, P: 1-10
Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques

By sectioning and sequencing the prefrontal cortex of humans, chimpanzees and macaques, He et al. compiled comprehensive transcriptome atlases of cortical layers. The study provides scores of previously uncharacterized layer-marker genes and more than a hundred human-specific genes, implying that the human neocortex has evolved more than was previously appreciated.

Zhisong He
Dingding Han
Philipp Khaitovich
Research17 Apr 2017
Nature Neuroscience

Volume: 20, P: 886-895
Inhibition of myeloid differentiation primary response protein 88 provides neuroprotection in early brain injury following experimental subarachnoid hemorrhage

Huiying Yan
Dingding Zhang
Chun-Hua Hang
ResearchOpen Access17 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Serum trace elements show association with thyroperoxidase autoantibodies in Thyroid Imaging Reporting and Data System (TI-RADS) 4 nodules

Yu Lv
Lei Zhang
Qian Xiang
ResearchOpen Access27 Aug 2024
Scientific Reports

Volume: 14, P: 1-14
Gender recognition of Guanyin in China based on VGGNet

Yongwen Huang
Dingding Chen
Lulu Wang
ResearchOpen Access21 Jun 2022
Heritage Science

Volume: 10, P: 1-17
Research on the variation law of floor stress information entropy in upper protective layer mining based on Brillouin optical fiber sensing

Jing Chai
Gaoyi Yang
Mingyue Weng
ResearchOpen Access08 Jan 2024
Scientific Reports

Volume: 14, P: 1-19
TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways

Yan Zhou
Tao Tao
Chunhua Hang
ResearchOpen Access07 Jan 2021
Cell Death & Disease

Volume: 12, P: 1-16
Multi-method joint monitoring study on strata behavior in shallow seam mining under bedrock gully

Jing Chai
Zhe Ma
Fengqi Qiu
ResearchOpen Access15 Sept 2023
Scientific Reports

Volume: 13, P: 1-14
A practical preparation of bicyclic boronates via metal-free heteroatom-directed alkenyl sp²-C‒H borylation

Bicyclic boronates are present in various bioactive molecules and functional materials, however, the efficient construction of this skeleton mainly relies on transition-metal-catalyzed processes. Here, the authors develop a practical preparation of bicyclic boronates via metal-free heteroatom-directed alkenyl sp²-C–H borylation and apply it to the synthesis of antibacterial agent QPX7728.

Pei-Ying Peng
Gui-Shan Zhang
Ping Tian
ResearchOpen Access23 Aug 2023
Communications Chemistry

Volume: 6, P: 1-9
High expression of new genes in trochophore enlightening the ontogeny and evolution of trochozoans

Fei Xu
Tomislav Domazet-Lošo
Guofan Zhang
ResearchOpen Access04 Oct 2016
Scientific Reports

Volume: 6, P: 1-10
Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice

Han Zhou
Xiaoyun Qian
Xia Gao
ResearchOpen Access24 Oct 2020
Cell Death & Disease

Volume: 11, P: 1-15
Analysis of the top coal stability of the large section open-off cut under the gob in thick seams slicing mining

Jing Chai
Yongliang Liu
Zhicheng Han
ResearchOpen Access05 Oct 2022
Scientific Reports

Volume: 12, P: 1-14
Improved virtual extensometer measurement method in complex multi-fracture situation

Jing Chai
Yibo Ouyang
Zhe Ma
ResearchOpen Access26 Apr 2022
Scientific Reports

Volume: 12, P: 1-14
Associations of 6p21.3 Region with Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy

Zimeng Ye
Ping Shuai
Yi Shi
ResearchOpen Access10 Feb 2016
Scientific Reports

Volume: 6, P: 1-9
GABA_A Receptor Coupling Junction and Pore GABRB3 Mutations are Linked to Early-Onset Epileptic Encephalopathy

Ciria C. Hernandez
Yujia Zhang
Robert L. Macdonald
ResearchOpen Access21 Nov 2017
Scientific Reports

Volume: 7, P: 1-18
Author Correction: Inhibition of myeloid differentiation primary response protein 88 provides neuroprotection in early brain injury following experimental subarachnoid haemorrhage

Huiying Yan
Dingding Zhang
Chun-Hua Hang
Amendments and CorrectionsOpen Access05 Apr 2024
Scientific Reports

Volume: 14, P: 1-3

Search

Copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of 1,3-enynes and azomethine ylides

Cas12e orthologs evolve variable structural elements to facilitate dsDNA cleavage

Study on mining deformation and fracture response mechanism and rock pressure law of super thick composite key roof

Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies

PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes

Sea cucumbers and their symbiotic microbiome have evolved to feed on seabed sediments

The oyster genome reveals stress adaptation and complexity of shell formation

Experimental study on dynamic evolutions of airflow in the ventilation network under the effect of mine gas outburst disasters

Photovoltaic nanocells for high-performance large-scale-integrated organic phototransistors

Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls

Research on stress release and pressure relief mechanism of underlying coal and rock under protective layer mining

Small reorganization energy acceptors enable low energy losses in non-fullerene organic solar cells

Whole-exome Sequencing Analysis Identifies Mutations in the EYS Gene in Retinitis Pigmentosa in the Indian Population

Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients

The locust genome provides insight into swarm formation and long-distance flight

Chromosome-level genome assembly and annotation of the tropical sea cucumber Stichopus monotuberculatus

Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity

Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii

Flexible ceramic nanofibrous sponges with hierarchically entangled graphene networks enable noise absorption

Facet effect of hematite on the hydrolysis of phthalate esters under ambient humidity conditions

Improving access to cardiovascular care for 1.4 billion people in China using telehealth

Comprehensive transcriptome analysis of neocortical layers in humans, chimpanzees and macaques

Inhibition of myeloid differentiation primary response protein 88 provides neuroprotection in early brain injury following experimental subarachnoid hemorrhage

Serum trace elements show association with thyroperoxidase autoantibodies in Thyroid Imaging Reporting and Data System (TI-RADS) 4 nodules

Gender recognition of Guanyin in China based on VGGNet

Research on the variation law of floor stress information entropy in upper protective layer mining based on Brillouin optical fiber sensing

TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways

Multi-method joint monitoring study on strata behavior in shallow seam mining under bedrock gully

A practical preparation of bicyclic boronates via metal-free heteroatom-directed alkenyl sp²-C‒H borylation

High expression of new genes in trochophore enlightening the ontogeny and evolution of trochozoans

Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice

Analysis of the top coal stability of the large section open-off cut under the gob in thick seams slicing mining

Improved virtual extensometer measurement method in complex multi-fracture situation

Associations of 6p21.3 Region with Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy

GABA_A Receptor Coupling Junction and Pore GABRB3 Mutations are Linked to Early-Onset Epileptic Encephalopathy

Author Correction: Inhibition of myeloid differentiation primary response protein 88 provides neuroprotection in early brain injury following experimental subarachnoid haemorrhage

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