Nature Search

Metal-free oxidation of aromatic carbon–hydrogen bonds through a reverse-rebound mechanism

Phthaloyl peroxide functions as a selective oxidant of C–H bonds in the transformation of arenes to phenols under mild conditions, in a reaction that is compatible with a wide array of functional groups.

Changxia Yuan
Yong Liang
Dionicio Siegel
Research10 Jul 2013
Nature

Volume: 499, P: 192-196
Preparation of phenols by phthaloyl peroxide–mediated oxidation of arenes

Dionicio Siegel et al. provide detailed instructions on implementing their facile, scalable, catalyst-free and functional group–tolerant approach to hydroxylating arenes.

Changxia Yuan
Anders M Eliasen
Dionicio Siegel
Protocols16 Oct 2014
Nature Protocols

Volume: 9, P: 2624-2629
Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons

Evguenia Ivakhnitskaia
Matthew R. Chin
Victor H. Guaiquil
ResearchOpen Access21 Jun 2021
Scientific Reports

Volume: 11, P: 1-13
Reverse metabolomics for the discovery of chemical structures from humans

A new discovery strategy, ‘reverse metabolomics’, facilitates high-throughput matching of mass spectrometry spectra in public untargeted metabolomics datasets, and a proof-of-concept experiment identified an association between microbial bile amidates and inflammatory bowel disease.

Emily C. Gentry
Stephanie L. Collins
Pieter C. Dorrestein
ResearchOpen Access05 Dec 2023
Nature

Volume: 626, P: 419-426
Global chemical effects of the microbiome include new bile-acid conjugations

Metabolomics data from germ-free and specific-pathogen-free mice reveal effects of the microbiome on host chemistry, identifying conjugations of bile acids that are also enriched in patients with inflammatory bowel disease or cystic fibrosis.

Robert A. Quinn
Alexey V. Melnik
Pieter C. Dorrestein
Research26 Feb 2020
Nature

Volume: 579, P: 123-129
A class of anti-inflammatory lipids decrease with aging in the central nervous system

Tan et al. reveal that a class of lipids, 3-sulfogalactosyl diacylglycerols, decrease in the central nervous system with aging. 3-sulfogalactosyl diacylglycerols are present in the human brain and suppress inflammation suggesting these lipids may play a role in age-related diseases and inflammation.

Dan Tan
Srihari Konduri
Alan Saghatelian
Research20 Oct 2022
Nature Chemical Biology

Volume: 19, P: 187-197
ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

A study in mammals identifies a new role for adipose triglyceride lipase in catalysing the esterification of hydroxyl fatty acids to produce biologically active fatty acid esters of hydroxy fatty acids.

Rucha Patel
Anna Santoro
Barbara B. Kahn
ResearchOpen Access08 Jun 2022
Nature

Volume: 606, P: 968-975
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

Imidazolopiperazines (IZPs) are a class of compounds under clinical development for malaria, but their mechanism of action is unclear. Here, the authors show that IZPs inhibit the parasite’s secretory pathway, affecting protein trafficking and export.

Gregory M. LaMonte
Frances Rocamora
Elizabeth A. Winzeler
ResearchOpen Access14 Apr 2020
Nature Communications

Volume: 11, P: 1-15
Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates

The sialic acid, Neu5Gc, is present in red meat and can be incorporated into host cell surface glycans triggering an inflammatory response. Here, a Neu5Gc-containing diet alters the murine gut microbiota, and bacterial sialidases specific for Neu5Gc were identified in human and mouse gut metagenomes, with purified sialidases able to cleave Neu5Gc from red meat.

Livia S. Zaramela
Cameron Martino
Karsten Zengler
Research23 Sept 2019
Nature Microbiology

Volume: 4, P: 2082-2089
Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA

Huijing Wang
Tina Chang
Dionicio Siegel
Research15 Apr 2019
The Journal of Antibiotics

Volume: 72, P: 498-506

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Metal-free oxidation of aromatic carbon–hydrogen bonds through a reverse-rebound mechanism

Preparation of phenols by phthaloyl peroxide–mediated oxidation of arenes

Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons

Reverse metabolomics for the discovery of chemical structures from humans

Global chemical effects of the microbiome include new bile-acid conjugations

A class of anti-inflammatory lipids decrease with aging in the central nervous system

ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates

Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA

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