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Showing 1–3 of 3 results
Advanced filters: Author: Dirk Mossmann Clear advanced filters

  • The transcription factors ZEB1 and YAP function in different pathways yet both activate aggressive behaviour in cancer cells. Here, the authors describe that the proteins physically interact and that this changes the transcriptional activity of ZEB1 from a repressor to an activator.

    • Waltraut Lehmann
    • Dirk Mossmann
    • Thomas Brabletz
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • Protein localization plays an important role in the regulation of cellular physiology. Here the authors use an integrated proteomics approach to localize proteins to the mitochondria and provide a detailed map of their specific localization within the organelle.

    • F.-Nora Vögtle
    • Julia M. Burkhart
    • Chris Meisinger
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • This Review discusses the interdependencies of mTOR signalling and metabolism pathways in cancer and how metabolic reprogramming in response to changes in mTOR signalling and vice versa can sustain tumorigenicity. The authors highlight therapeutic opportunities when targeting metabolism and mTOR.

    • Dirk Mossmann
    • Sujin Park
    • Michael N. Hall
    Reviews
    Nature Reviews Cancer
    Volume: 18, P: 744-757