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Modulation of bone marrow haematopoietic stem cell activity as a therapeutic strategy after myocardial infarction: a preclinical study

Rettkowski, Romero-Mulero et al. show that myocardial infarction impacts bone marrow haematopoietic stem cells and leads to inflammatory myelopoiesis, which can be dampened by treatment with 4-oxo-retinoic acid, promoting cardiac recovery.

Jasmin Rettkowski
Mari Carmen Romero-Mulero
Nina Cabezas-Wallscheid
ResearchOpen Access02 Apr 2025
Nature Cell Biology

Volume: 27, P: 591-604
GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome

Stoffers, Wolf et al. report that, in virus-mediated myocarditis, GPR15 deficiency delays the recruitment of T cells into cardiac tissue, which impairs viral elimination and leads to delayed but also prolonged inflammation and, thus, adverse cardiac outcomes.

Bastian Stoffers
Hanna Wolf
Diana Lindner
ResearchOpen Access27 Dec 2023
Nature Cardiovascular Research

Volume: 3, P: 76-93
Author Correction: GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome

Bastian Stoffers
Hanna Wolf
Diana Lindner
Amendments and CorrectionsOpen Access23 Aug 2024
Nature Cardiovascular Research

Volume: 3, P: 1177
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research

Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.

Thomas Clavel
Franziska Faber
Lisa Maier
Reviews29 Apr 2025
Nature Biotechnology

Volume: 43, P: 878-888
High-sensitivity assays for troponin in patients with cardiac disease

Troponin is a widely used biomarker in patients with cardiac disease. In this Review, Westermann et al. describe the development of high-sensitivity assays for troponin, and their practical use in clinical diagnosis of acute myocardial infarction. Elevated concentrations of troponin in myocardial injury and chronic cardiac disease are also discussed.

Dirk Westermann
Johannes Tobias Neumann
Stefan Blankenberg
Reviews06 Apr 2017
Nature Reviews Cardiology

Volume: 14, P: 472-483
Combination of high resolution MRI with 3D-printed needle guides for ex vivo myocardial biopsies

Simon Reiss
Julien Thielmann
Michael Bock
ResearchOpen Access05 Jan 2024
Scientific Reports

Volume: 14, P: 1-9
Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany

Vera Oettinger
Adrian Heidenreich
Peter Stachon
ResearchOpen Access19 Oct 2022
Scientific Reports

Volume: 12, P: 1-7
Interventional real-time molecular MRI for targeting early myocardial injury in a pig model

Timo Heidt
Simon Reiss
Constantin von zur Mühlen
ResearchOpen Access03 Feb 2025
npj Imaging

Volume: 3, P: 1-10
Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Here authors show that GDF15, a cytokine that is produced by cancer cells, prevents T cells from extravasation into the tumour microenvironment. Low availability of T cells in GDF-15-expressing tumours thus precludes effective immune therapy.

Markus Haake
Beatrice Haack
Jörg Wischhusen
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-19
Molecular consequences of SARS-CoV-2 liver tropism

Wanner et al. demonstrate SARS-CoV-2 liver tropism and identify transcriptional and proteomic profiles of SARS-CoV-2 liver samples that show similarities to previously characterized hepatotropic viruses.

Nicola Wanner
Geoffroy Andrieux
Tobias B. Huber
ResearchOpen Access28 Mar 2022
Nature Metabolism

Volume: 4, P: 310-319
Spatial orchestration of mitochondrial translation and OXPHOS complex assembly

Using super-resolution microscopy and cryo-electron microscopy, Stoldt et al. show that mitochondrial transcript translation and OXPHOS complex assembly are spatially partitioned within the mitochondrial membrane.

Stefan Stoldt
Dirk Wenzel
Stefan Jakobs
Research16 Apr 2018
Nature Cell Biology

Volume: 20, P: 528-534
INOVATYON/ ENGOT-ov5 study: Randomized phase III international study comparing trabectedin/pegylated liposomal doxorubicin (PLD) followed by platinum at progression vs carboplatin/PLD in patients with recurrent ovarian cancer progressing within 6-12 months after last platinum line

N. Colombo
A. Gadducci
Alexander Reinthaller
ResearchOpen Access09 Feb 2023
British Journal of Cancer

Volume: 128, P: 1503-1513
Photon-counting computed tomography of coronary and peripheral artery stents: a phantom study

Thomas Stein
Jana Taron
Jakob Weiss
ResearchOpen Access08 Sept 2023
Scientific Reports

Volume: 13, P: 1-11
CAR links hypoxia signaling to improved survival after myocardial infarction

Fabian Freiberg
Meghna Thakkar
Michael Gotthardt
ResearchOpen Access20 Mar 2023
Experimental & Molecular Medicine

Volume: 55, P: 643-652
Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension

Differential increased cardiac expression of Cpxm2 was assigned to cardiac hypertrophy in SHRSP rats. Cpxm2 knock-out (KO) in mice reduced cardiac hypertrophy and remodeling in DOCA salt hypertension

Katja Grabowski
Laura Herlan
Reinhold Kreutz
ResearchOpen Access16 Dec 2021
Hypertension Research

Volume: 45, P: 292-307
Prognostic model for newly diagnosed CLL patients in Binet stage A: results of the multicenter, prospective CLL1 trial of the German CLL study group

Manuela A. Hoechstetter
Raymonde Busch
Michael Hallek
Research10 Feb 2020
Leukemia

Volume: 34, P: 1038-1051
Low immunogenicity of endothelial derivatives from rat embryonic stem cell-like cells

Juliane Ladhoff
Michael Bader
Martina Seifert
Research24 Feb 2009
Cell Research

Volume: 19, P: 507-518

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Modulation of bone marrow haematopoietic stem cell activity as a therapeutic strategy after myocardial infarction: a preclinical study

GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome

Author Correction: GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome

Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research

High-sensitivity assays for troponin in patients with cardiac disease

Combination of high resolution MRI with 3D-printed needle guides for ex vivo myocardial biopsies

Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany

Interventional real-time molecular MRI for targeting early myocardial injury in a pig model

Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Molecular consequences of SARS-CoV-2 liver tropism

Spatial orchestration of mitochondrial translation and OXPHOS complex assembly

INOVATYON/ ENGOT-ov5 study: Randomized phase III international study comparing trabectedin/pegylated liposomal doxorubicin (PLD) followed by platinum at progression vs carboplatin/PLD in patients with recurrent ovarian cancer progressing within 6-12 months after last platinum line

Photon-counting computed tomography of coronary and peripheral artery stents: a phantom study

CAR links hypoxia signaling to improved survival after myocardial infarction

Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension

Prognostic model for newly diagnosed CLL patients in Binet stage A: results of the multicenter, prospective CLL1 trial of the German CLL study group

Low immunogenicity of endothelial derivatives from rat embryonic stem cell-like cells

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