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Showing 1–7 of 7 results
Advanced filters: Author: Dominic Waithe Clear advanced filters

  • Broken chromosomes are lethal to cells with breaks ends often containing complex DNA damage. Here, the authors reveal a key role for the SNM1A enzyme in cleaning up break ends. Key anticancer drugs, and therapeutic radiation produce complex DNA breaks, making SNM1A an appealing therapeutic target.

    • Lonnie P. Swift
    • B. Christoffer Lagerholm
    • Peter J. McHugh
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • The Membrane-Proximal External Region (MPER) of the HIV Env gp41 subunit is a target for broadly neutralizing antibodies. Here, the authors apply super-resolution stimulated emission depletion (STED) microscopy on single virions and provide insights into how the MPER epitope is recognized.

    • Pablo Carravilla
    • Jakub Chojnacki
    • José L. Nieva
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Mechanisms that operate during embryonic development to restrict cell fate are currently under investigation. Here the authors characterise the role of SCL/TAL1 at the onset of blood specification in embryonic development using mouse EB differentiation culture as a model system.

    • Hedia Chagraoui
    • Maiken S. Kristiansen
    • Catherine Porcher
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Self-interacting chromatin domains encompass genes and their cis-regulatory elements. Here the authors use high-resolution chromosome conformation capture and super-resolution imaging to study a 70 kb ___domain that includes the mouse α-globin regulatory locus and find that a tissue-specific self-interacting chromatin ___domain forms independently of enhancer-promoter interactions.

    • Jill M. Brown
    • Nigel A. Roberts
    • Veronica J. Buckle
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • To become infectious, HIV-1 particles undergo a maturation process involving the clustering of envelope glycoprotein Env. Here, Chojnacki et al. employ super-resolution STED-FCS microscopy to study dynamics of Env molecules on HIV-1 particles and show that Env undergoes a maturation-induced increase in mobility.

    • Jakub Chojnacki
    • Dominic Waithe
    • Christian Eggeling
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10