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This study investigates how homeostatic mechanisms endow sensory representations in the auditory cortex with resilience against neuron loss. The map of sounds has the ability to recover after microablation by recruiting previously unresponsive neurons.

Electrogenerated gas bubbles impair the efficiency of electrolysis and require a deeper insight into their dynamics. Here, the authors describe a transport mechanism in which electrolyte droplets from the coalescence of microbubbles are sprayed into H₂ bubbles.

Path-integral Monte Carlo (PIMC) techniques are used to simulate thermodynamic properties of warm dense matter but currently suffer from uncontrolled approximations and exponentially scaling computational costs. Here, the authors provide a way to overcome these issues, developing PIMC simulations of warm dense beryllium in agreement with x-ray Thomson scattering.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Filamin C is a key actin-binding protein involved in cardiomyopathies and musculoskeletal disorders. Here, Wang et al reveal that it interacts with the heat shock protein HSPB7 under biomechanical stress, forming a stable hetero-dimer which is regulated by phosphorylation.

A precise structure measurement of liquid carbon at pressures of around 1 million atmospheres obtained by in situ X-ray diffraction at an X-ray free-electron laser shows a complex fluid with transient bonding and approximately four nearest neighbours on average.

Gut microbiota contribute to the pathogenesis of ulcerative colitis (UC), but the molecular mechanisms are still unclear. Here the authors show that colonic fluid from patients with UC is enriched for bacteria extracellular vesicles (BEV) coated with host IgA, and that these IgA-coated BEV may activate CD89⁺ immune cells to aggravate inflammation and colitis in mouse models.

A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.

Moscot is an optimal transport approach that overcomes current limitations of similar methods to enable multimodal, scalable and consistent single-cell analyses of datasets across spatial and temporal dimensions.

Zebrafish show robust heart regeneration after injury. Here they show that zebrafish cardiomyocytes experience replication stress, which BMP signaling alleviates via a conserved mechanism of replication fork restart, suggesting a potential for anti-aging and regenerative therapies.

The NV center in diamond has been used extensively in sensing; however single shot readout of its spin remains challenging, requiring complex optical setups. Here, Irber et al. demonstrate a more robust scheme that achieves single-shot readout even when using inefficient detection optics.

Fatty liver disease exacerbates atherosclerosis, but the underlying mechanisms remain unclear. Here, the authors show that D-dopachrome tautomerase (D-DT/MIF-2) acts as an atypical chemokine, promoting both atherosclerosis and hepatic lipid accumulation.

Integrated solutions for the analysis of complex 3D and live cell images remain scarce. Here, the authors present Cecelia, an image analysis toolbox based on R and Python, which enables researchers to quantify large scale tissue sections as well as live cell imaging data. Its modular design makes it applicable to a variety of use cases.

A climatic record from desert speleothems shows that the central Arabian interior experienced recurrent humid intervals over the past 8 million years, which likely facilitated mammalian dispersals between Africa and Eurasia.

Strong interaction is blind to quark flavor, so collisions of nuclei with the same number of protons and neutrons should generate the same number of charged and neutral kaons. Here, instead, the authors show a significant excess of charged over neutral kaon production in Ar+Sc nuclei collisions, compatibly with earlier measurements which however suffered from larger uncertainties, and show that known effects cannot explain the result.

The study shows that HPV activation requires a minimum glycan length, which enlarges and softens the virus. Using virological assays, AFM, and HDX-MS, the authors propose a model explaining HPV structural activation and its role in infection.

Nuclear magnetic resonance is vital for analysis and diagnostics but suffers from insensitivity as only a small fraction of all NMR-active nuclei are spin-polarized and contribute to the signal. Here Hövener et al. describe an effect that replenishes nuclear spin polarization continuously for a considerably enhanced performance at low field.

The Nr4a family of nuclear receptors has been implicated in thymocyte central tolerance via clonal deletion and regulatory T cell induction. Here the authors show, using mouse bone marrow chimeras, that Nr4a1 and Nr4a3 are also redundantly required for Bcl211/BIM induction and contribute to an anergy-like transcriptome in auto-reactive thymocytes.

Analysis of policies for promotion criteria to full professor from academic institutions and government agencies worldwide reveals considerable variation in assessment practices, particularly between the Global North and South.

Observations of the formation of individual stripes in a mixed-dimensional cold-atom Fermi–Hubbard quantum simulator are described, enhancing understanding of the phase diagram of high-temperature superconducting materials and the relationship between charge pairs and stripes.

Linearly polarized orbital angular momentum-carrying hard X-ray beams are induced using spiral Fresnel zone plates. By sending the hard X-ray beams to disordered enantiopure molecular complexes, the helicity-dependent and chiral-sensitive signal is obtained.

Computational methods are becoming an increasingly important part of biological research. Using the Rosetta framework as an example, the authors demonstrate how community-driven development of computational methods can be done in a reproducible and reliable fashion.

The use of harmful solvents to fabricate stable devices hampers the commercialization of perovskite solar cells. Here, the authors introduce a biorenewable solvent system and precursor-phase engineering to realize stable formamidinium lead triiodide-based solar cells.

Surveys conducted in 15 European countries in 2016 and 2022 show stable attitudes towards asylum seekers and refugees with different attributes over this period with a slight increase in support for asylum seekers in general.

Some cancer patients first present with metastases where the ___location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

An analysis of the search behaviour of recruiters on a Swiss online recruitment platform shows that jobseekers from minority ethnic groups are less likely to be contacted by recruiters, and also provides evidence of gender-based discrimination.

The authors measure picosecond spin pumping in FeRh as a function of temperature by optical pump-THz emission spectroscopy. In the antiferromagnetic phase of FeRh enhanced spin pumping above the value measured in the ferromagnetic phase is observed.

Effective and regulated activation of the Mcm2-7 helicase underlies faithful genome replication. Here the authors reveal mechanistic detail how the pre-loading complex proteins TopBP1 and GINS interact and, thus, how the helicase activator GINS loads on Mcm2-7 during replication origin firing.

Nitrenes are compounds featuring a monovalent nitrogen atom, and they are typically formed as transient intermediates in organic synthesis. They have been the subject of matrix studies for decades, but their stabilization remains challenging. Now, two independent works report the isolation of triplet arylnitrenes stabilized by a sterically encumbered substituent.

A successful silicon spin qubit design should be rapidly scalable by benefiting from industrial transistor technology. This investigation of exchange interactions between two FinFET qubits provides a guide to implementing two-qubit gates for hole spins.

Probing the molecular dynamics of the membrane motor, prestin, with biophysical measures and MD simulations, Kuwabara et al. find that an elevator-like ___domain movement across the membrane produces the unique piezoelectric behavior.

Human encroachment into nature alters species communities and can lead to changes in disease dynamics. Here, Meyer et al. find that coronavirus prevalence increased in less diverse bat communities, which were dominated by susceptible host species.

Identification of senescent cells in vivo remains a challenging task. Here the authors present and validate a senescence gene set called SenMayo enriched in human and murine aged tissues.

This Review describes sample preparation strategies for time-resolved methods in structural biology, with a focus on cryo-EM and X-ray crystallography, including opportunities for cross-fertilization of ideas between these fields.

In a phase 2 randomized control trial, intermittent senolytic therapy administered to postmenopausal women did not result in a reduction in the bone resorption marker, serum CTx, compared to control at 20 weeks.

This preclinical study demonstrates the potential of a drug repurposing strategy using the coadministration of tamsulosin, metoprolol, and bromocriptine to provide a mutation-agnostic therapy for inherited retinal degeneration.

JNJ-1802—a highly potent dengue virus inhibitor—blocks the NS3–NS4B interaction within the viral replication complex, and is highly effective against viral infection with DENV-1 or DENV-2 in non-human primates.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

A programmable quantum processor based on encoded logical qubits operating with up to 280 physical qubits is described, in which improvement of algorithmic performance using a variety of error-correction codes is enabled.