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Showing 1–6 of 6 results
Advanced filters: Author: Dominik Lindenhofer Clear advanced filters

  • Lindenhofer, Haendeler, Esk, Littleboy et al. perform whole-tissue lineage tracing in human cerebral organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage size depending on tissue demands.

    • Dominik Lindenhofer
    • Simon Haendeler
    • Jürgen A. Knoblich
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 710-718

  • The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing through cellular differentiation at scale.

    • Michael Scherer
    • Indranil Singh
    • Lars Velten
    ResearchOpen Access
    Nature
    P: 1-10

  • The authors show that loss-of-interaction with the nuclear importer, TNPO3, causes cytoplasmic mislocalization of RBM20 variants linked to severe cases of dilated cardiomyopathy. Restoring their nuclear localization alleviates the disease phenotype.

    • Julia Kornienko
    • Marta Rodríguez-Martínez
    • Lars M. Steinmetz
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Organoids derived from human stem cells recapitulate the structure and functions of human blood vessels, and can be used to model and identify regulators of diabetic vasculopathy.

    • Reiner A. Wimmer
    • Alexandra Leopoldi
    • Josef M. Penninger
    Research
    Nature
    Volume: 565, P: 505-510

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57