Here, in order to gain insight into the relationship between rates of genomic evolution and organismal adaptation, genomes sampled through 40,000 generations are sequenced from a laboratory population of Escherichia coli. The results indicate that the coupling between genomic and adaptive evolution is complex and can be counterintuitive even in a constant environment, with beneficial mutations surprisingly uniform over time whereas neutral substitutions were highly variable.
- Jeffrey E. Barrick
- Dong Su Yu
- Jihyun F. Kim
