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Endothelial injury drives vascular diseases like atherosclerosis, but key regulators are unclear. Here, the authors show that endothelial major vault protein (MVP) acts as an intracellular regulator promoting Parkin-mediated mitophagy, thereby antagonizing vascular remodeling and suggesting its role as a potential therapeutic target.

The active site of a solid catalyst depends strongly on the specific reaction. Here, the authors reveal distinct active sites for CO₂ and CO hydrogenation to methanol over ZnO-ZrO₂, using experimental surface kinetics, structural characterization, and theoretical modeling.

Developing artificial bulk materials that seamlessly integrate rigid inorganic components with ductile organic constituents is vital for replicating the mechanical properties of natural biological composites but elusive. Here, the authors report a calcium phosphate-based inorganic-organic hybrid metamaterial that seamlessly integrates the functional traits of inorganic and organic constituents.

A template-free magnetization strategy for inverse programming of hard-magnetic domains embedded in solvent-responsive hydrogel is reported using a photodosage-based printing method, achieving shape morphing into 3D curved surfaces under the actuation of a magnetic field.

Zhong et al. show that, in response to chimeric antigen receptor (CAR) T cell targeting, solid tumors increase the secretion of small extracellular vesicles carrying tumor antigens that are transferred to CAR T cells, resulting in fratricide and reduced antitumor activity.

The authors show that SARS-CoV-2-specific T cells in the lung are key to fighting infection and persist after viral clearance, contributing to long-term immunity and protection.

A telomere-to-telomere genome assembly of allohexaploid bread wheat cv. Chinese Spring (CS-IAAS), along with transcriptomic and proteomic data, highlights wheat genome complexity and its structural and functional features.

Bacterial-host competition for micronutrients and inefficient immune responses undermine antimicrobial immunotherapy. Su et al. design an immunostimulatory metalloantibiotic and explore potential sono-metalloimmunotherapy (SMIT) for the treatment of clinical orthopaedic infections, in a murine model.

Semi-aquatic robots rely on surface tension for propulsion, which implies that breaking the water surface is a limitation. Here, the authors developed a soft robot with a superhydrophobic body, achieving high jumping height and take-off velocity.

Here the authors reveal that phase‐separated nuclear CCER1 condensates are required for male fertility by mediating chromatin condensation and histone epigenetic modification, while loss‐of‐function variants of human CCER1 are pathogenic in patients with nonobstructive azoospermia (NOA).

In the CNS, glutamatergic neurons directly control functional hyperemia via synaptic-like transmission onto arteriolar smooth muscle cells. Inhibiting this process reduces brain atrophy following cerebral ischemia.

The preparation of mesoporous zeolites is important for their incorporation into industrially relevant applications. Here, the authors design a single quaternary ammonium head amphiphilic template, which directs the formation of mesostructured crystalline zeolites due to π-stacking supramolecular interactions.

The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.

In the phase 3 EVER-132-002 trial, patients with HR⁺HER2⁻ metastatic breast cancer from Asia were treated with the Trop-2-directed antibody–drug conjugate sacituzumab govitecan or chemotherapy, and those receiving sacituzumab govitecan experienced prolonged progression-free survival compared with patients treated with chemotherapy.

Modules of foldable crystalline silicon solar cells retain their power-conversion efficiency after being subjected to bending stress or exposure to air-flow simulations of a violent storm.

Metabolic diseases are associated with chronic, low-grade inflammation. Here the authors show that major vault protein (MVP) suppresses NF-κB signalling in macrophages via an IRAK1–TRAF6 axis and that loss of MVP in myeloid cells exacerbates the inflammatory response in mice fed a high fat diet.

Although hexagonally close packed structures are predicted, obtaining direct experimental evidence has been a challenge. Here, the authors report direct evidence for this phaseby regulation of phase behaviour by deliberate breaking of molecular symmetry.

Aurora-A kinase is frequently over-expressed in tumours. Here, the authors show that it modulates the activity of lactate dehydrogenase B, resulting in enhanced glycolysis, bio-synthesis and tumour growth.

Innate lymphoid cells (ILC) have been shown to be involved in a range of inflammatory contexts but how their cellular lineage is regulated is not fully established. Here the authors show a role for circular RNA circTmem241 in the differentiation of ILC3 via initiation of Elk3 transcription.

Varying growth temperatures enables the tuning of the degree of disorder, which is fully described by the absence/presence of medium-range order and temperature-dependent densities of nanocrystallites, and electrical conductivity in amorphous monolayer carbon films.

Non-alcoholic fatty liver disease is a growing health burden with limited treatment options worldwide. Herein the authors report a randomized, double-blind, placebo-controlled, multiple-dose trial of a first-in-class pan-phosphodiesterase inhibitor ZSP1601 in NAFLD patients.

Interfacial non-wettability between biocompatible iron oxide and liquid metal caused by the substantial mismatch in surface energy remains an issue. Here, the authors introduce a silver intermediate layer to reduce compositional mismatch and improve the wetting ability between iron oxide and liquid metal.

The toxicity arising from generalised stimulation of T cells restricts applicability of CD137 agonists in cancer immune therapy. Here authors show that a bispecific antibody blocking PD-1 while activating CD137 efficiently restricts T cell activation to the tumour microenvironment, resulting in efficient tumour control and reduced liver toxicity.

Citrullus super-pangenome constructed using 27 telomere-to-telomere assemblies encompassing all seven Citrullus species highlights genomic diversity across wild and cultivated watermelons and the potential for crop improvement.

By focusing a sub-relativistic infrared laser pulse onto a silica target, a periodic deflection pattern of attosecond electron pulse trains is observed. It reveals these subcycle charge dynamics with a streaking speed of ~60 μrad as⁻¹.

Researchers overcome the typical scintillator trade-off between high efficiency and speed. In organic scintillators, researchers drove hot excitons into fast singlet emission states without involving the lowest triplet states, which led to a fast radiative lifetime and strong light yield that may be applicable to ultrafast detection and imaging.

Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). Here, the authors analysed the primary tumours, lymph node metastasis and liver metastasis of ten CRC patients and reveal co-existence of diverse modes of metastasis in the same patient.

The poor contact at poly(3-hexylthiophene)/perovskite interface has led to unsatisfactory performance in solar cells. To resolve this issue, the authors introduce a molecular bridge to form a charge transport channel, realizing devices with maximum efficiency value of 22.87% and long-term stability.

A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.

Chromosome-scale sequence assemblies of 20 diverse varieties of barley are used to construct a first-generation pan-genome, revealing previously hidden genetic variation that can be used by studies aimed at crop improvement

Heterogeneous populations of basal cells in the prostate epithelium contain stem cells. Here the authors show that Zeb1 marks a pool of prostate epithelial stem cells that self-renew, generate prostate glandular structures with all 3 epithelial cell types and are required for prostate basal cell development.

Due to the polygenic nature of most diseases, simultaneous correction or introduction of single nucleotide variants is needed. Here, the authors demonstrated the feasibility of multiplex base editing for polygenes disease modeling in cynomolgus monkey embryos with high specificity.

The supply of oxygen species for dynamic therapy is a major limitation. Here, the authors report on a complex of calcium peroxide with photo/chemo dynamic agents, where NIR heating causes the release of calcium peroxide to generate oxygen and hydrogen peroxide for photodynamic and chemodynamic therapy.

The structure of nanoparticles strongly influences their properties. Here, the authors use single crystal X-ray diffraction to resolve the crystal structures of Ag₁₃₆ and Ag₃₇₄nanoparticles, enabling the observation of local structure distortion and the lower size limit of surface plasmon resonance.

Aqueous solutions under nanoscale confinement exhibit interesting physicochemical properties. This work reports evidence on the spontaneous formation of two-dimensional alkali chloride crystalline/non-crystalline nanostructures in dilute aqueous solution under nanoscale confinement by computer simulations.

Here, the authors show that enhanced tropical cyclone activity was synchronized with increased Asian dust emissions during the Little Ice Age, implying a mechanism linking tropical cyclone climatology to Asian dust levels, at 100 to 1000 year scales.

Manual postprocessing of computed tomography angiography (CTA) images is extremely labor intensive and error prone. Here, the authors propose an artificial intelligence reconstruction system that can automatically achieve CTA reconstruction in healthcare services.

Rapid growth of highly crystalline Covalent organic framework (COF) materials remains challenging. Here, the authors accelerate single-crystal polymerization using supercritical CO2 and realize the fabrication of two-dimensional COF single crystals within several minutes.