Chronic histiocytic intervillositis of unknown origin is a rare but serious and hard-to-prevent condition, leading to repeated pregnancy losses. Here authors show that high-grade cases are associated with inflammasome activation in placental samples, and they report the birth of healthy full-term infants following sustained inflammasome inhibition in three high-risk pregnancies.
- Aurélien Mattuizzi
- Fanny Sauvestre
- Estibaliz Lazaro
