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Showing 1–13 of 13 results
Advanced filters: Author: Edward C. Twomey Clear advanced filters

  • The authors show that Memantine—an FDA-approved NMDA receptor inhibitor—also blocks calcium-permeable AMPA receptors via a distinct mechanism requiring calcium permeability and auxiliary subunits; revealing a therapeutic strategy to target these proteins.

    • Elisa Carrillo
    • Alejandra Montaño Romero
    • Vasanthi Jayaraman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9

  • TARPs are tetraspanins that are claudin-like but regulate glutamate receptors. Here, the moieties that define TARP function and distinguish them from claudins are uncovered through cryo-EM, structure prediction, and electrophysiology.

    • W. Dylan Hale
    • Alejandra Montaño Romero
    • Edward C. Twomey
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-7

  • Using cryo-electron microscopy, the authors reveal the mechanism by which perampanel-like molecules inhibit AMPA receptors. They show that the inhibitors decouple the ligand-binding ___domain from the ion channel after neurotransmitter binding and outcompete positive modulators.

    • W. Dylan Hale
    • Alejandra Montaño Romero
    • Edward C. Twomey
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1669-1679

  • The radiative forcing due to aerosol-cloud interactions constitutes one of the largest uncertainties of anthropogenic radiative forcing. Direct satellite measurements of the relevant aerosol properties reveal that the resulting cooling from anthropogenic aerosols is much stronger than previously thought.

    • Otto P. Hasekamp
    • Edward Gryspeerdt
    • Johannes Quaas
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-7

  • Aerosol pollution from shipping contributes to cooling but also leads to premature mortality and morbidity. Here the authors combine emission inventories, atmospheric models and health risk functions to show how cleaner marine fuels will reduce premature deaths and childhood asthma but results in larger warming.

    • Mikhail Sofiev
    • James J. Winebrake
    • James J. Corbett
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • There is high prevalence of whole genome duplication (WGD) in high grade serous ovarian cancer. Here, the authors compare tumours with and without WGD and find that those that acquired WGD early during tumour evolution are associated with worse survival and have the lowest expression of MHC-II.

    • Nikki L. Burdett
    • Madelynne O. Willis
    • Elizabeth L. Christie
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • The structures of AMPA receptors in complex with auxiliary proteins are resolved by cryo-electron microscopy, and reveal conformational and permeation pathway changes that are associated with activation and desensitization of ionotropic glutamate receptors.

    • Edward C. Twomey
    • Maria V. Yelshanskaya
    • Alexander I. Sobolevsky
    Research
    Nature
    Volume: 549, P: 60-65

  • A new cryo-EM study reveals how ATP hydrolysis in the p97 ATPase is coordinated to unfold the protein’s substrates and provides new foundations for the design of small molecule therapeutics targeting p97 in cancer, neurodegeneration and viral infection.

    • Edward C. Twomey
    News & Views
    Nature Structural & Molecular Biology
    Volume: 28, P: 538-539

  • The cryo-electron microscopy structure of the calcium channel TRPV6 in its open and closed states demonstrates a novel gating mechanism involving an alanine hinge.

    • Luke L. McGoldrick
    • Appu K. Singh
    • Alexander I. Sobolevsky
    Research
    Nature
    Volume: 553, P: 233-237