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Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction

A national prospective study of patients requiring hospitalization for COVID-19 demonstrates global cognitive deficits at 1 year, associated with elevated brain injury markers and reduced gray matter volume.

Greta K. Wood
Brendan F. Sargent
E. Charles Leek
ResearchOpen Access23 Sept 2024
Nature Medicine

Volume: 31, P: 245-257
Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

The COP9 signalosome (CSN) regulates Cullin-RING Ligase 2 (CRL2) but the molecular basis for their interaction is unknown. Here the authors use structural mass spectrometry and cryo-EM approaches to assess the structures and dynamics of CSN-CRL2 complexes.

Sarah V. Faull
Andy M. C. Lau
Argyris Politis
ResearchOpen Access23 Aug 2019
Nature Communications

Volume: 10, P: 1-13
Growth of Transformed C-127 Cell in Bioreactors for Large-Scale t-PA Production

Edward R. McKillip
Adele S. Giles
Richard N. Hjorth
Research01 Sept 1991
Bio/Technology

Volume: 9, P: 805-808
Pancuronium Does Not Alter the Hemodynamic Status of Piglets after Normoxia or Hypoxia

David Easa
Catherine F T Uyehara
Sim Helen
Research01 Apr 1993
Pediatric Research

Volume: 33, P: 365-372
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict D. Michael
Cordelia Dunai
David K. Menon
Amendments and CorrectionsOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1
FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells

Single molecule tracking of fluorescent proteins in live cells is temporally limited by fluorophore photobleaching. Here the authors show using fluorophore pairs that FRET competes with photobleaching to improve photostability and allow longer-term tracking of both single proteins and complexes.

Srinjan Basu
Lisa-Maria Needham
Ernest D. Laue
ResearchOpen Access28 Jun 2018
Nature Communications

Volume: 9, P: 1-14
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Spemann's organizer and self-regulation in amphibian embryos

Self-regulation is one of the most intriguing properties of early embryos. In 1924, Spemann and Mangold carried out the most famous experiment in experimental embryology, which led to the identification of the first self-organizing centre — the Spemann's organizer.

Edward M. De Robertis
Reviews01 Feb 2006
Nature Reviews Molecular Cell Biology

Volume: 7, P: 296-302
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Efficacy of Live, Attenuated Human Rotavirus Vaccine (89-12) in Infants

David I Bernstein
David A Sack
Richard L Ward
Research01 Apr 1999
Pediatric Research

Volume: 45, P: 157
The effect of hematocrit on in vitro bilirubin photoalteration

Debra T. Linfield
Angelo A. Lamola
David K. Stevenson
Research16 Nov 2015
Pediatric Research

Volume: 79, P: 387-390
Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study

Rajish S. K. Shil
Adam Seed
Hannah Stark
ResearchOpen Access27 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Faster detection of asymptomatic COVID-19 cases among care home staff in England through the combination of SARS-CoV-2 testing technologies

Finola Ryan
Joanna Cole-Hamilton
Tom Fowler
ResearchOpen Access29 Mar 2024
Scientific Reports

Volume: 14, P: 1-8

Search

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction

Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

Growth of Transformed C-127 Cell in Bioreactors for Large-Scale t-PA Production

Pancuronium Does Not Alter the Hemodynamic Status of Piglets after Normoxia or Hypoxia

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Spemann's organizer and self-regulation in amphibian embryos

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Efficacy of Live, Attenuated Human Rotavirus Vaccine (89-12) in Infants

The effect of hematocrit on in vitro bilirubin photoalteration

Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study

Faster detection of asymptomatic COVID-19 cases among care home staff in England through the combination of SARS-CoV-2 testing technologies

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