Nature Search

Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

Tony Kouzarides
Edward Ziff
Research17 Aug 1989
Nature

Volume: 340, P: 568-571
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.

Gabriel Balmus
Delphine Larrieu
Stephen P. Jackson
ResearchOpen Access27 Apr 2018
Nature Communications

Volume: 9, P: 1-14
Mechanism of activation of a human oncogene

Clifford J. Tabin
Scott M. Bradley
Esther H. Chang
Research11 Nov 1982
Nature

Volume: 300, P: 143-149
Chloroplast DNA sequence from a Miocene Magnolia species

Edward M. Golenberg
David E. Giannasi
Gerard Zurawski
Research12 Apr 1990
Nature

Volume: 344, P: 656-658
Yeast and mammalian ras proteins have conserved biochemical properties

Gretchen L. Temeles
Jackson B. Gibbs
Edward M. Scolnick
Research21 Feb 1985
Nature

Volume: 313, P: 700-703
Dense sampling of bird diversity increases power of comparative genomics

A dataset of the genomes of 363 species from the Bird 10,000 Genomes Project shows increased power to detect shared and lineage-specific variation, demonstrating the importance of phylogenetically diverse taxon sampling in whole-genome sequencing.

Shaohong Feng
Josefin Stiller
Guojie Zhang
Research11 Nov 2020
Nature

Volume: 587, P: 252-257
Human Propionyl CoA Carboxylase: Some Properties of the Partially Purified Enzyme in Fibroblasts from Controls and Patients with Propionic Acidemia

Y Edward Hsia
Catherine J Scully
Leon E Rosenberg
Research01 Jun 1979
Pediatric Research

Volume: 13, P: 746-751
Common and distinct transcriptional signatures of mammalian embryonic lethality

The transcriptional signature of embryonic lethality has not been defined. Here, the authors, as part of the Deciphering the Mechanisms of Developmental Disorders programme, define genes causing murine embryonic lethality around E9.5 and identify developmental delay transcriptional signatures.

John E. Collins
Richard J. White
Elisabeth M. Busch-Nentwich
ResearchOpen Access26 Jun 2019
Nature Communications

Volume: 10, P: 1-16
Author Correction: Dense sampling of bird diversity increases power of comparative genomics

Shaohong Feng
Josefin Stiller
Guojie Zhang
Amendments and CorrectionsOpen Access08 Apr 2021
Nature

Volume: 592, P: E24
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Steve Brown and colleagues report an analysis of 20 phenotyping tests, including 413 data parameters, across 449 mutant mouse alleles. They identify widespread pleiotropy and assign putative functions to genes that lacked previous phenotypic annotation.

Martin Hrabě de Angelis
George Nicholson
Steve D M Brown
Research27 Jul 2015
Nature Genetics

Volume: 47, P: 969-978
Tumors induce de novo steroid biosynthesis in T cells to evade immunity

Multiple mechanisms of immune evasion exploited by cancer cells have been described. Here, the authors show that genetic inactivation or pharmacological inhibition of tumor-induced Th2-mediated de novo steroidogenesis are sufficient to restore an efficient anti-tumor immune response and restrict tumor growth.

Bidesh Mahata
Jhuma Pramanik
Sarah A. Teichmann
ResearchOpen Access17 Jul 2020
Nature Communications

Volume: 11, P: 1-15
The tuatara genome reveals ancient features of amniote evolution

The approximately 5-Gb tuatara (Sphenodon punctatus) genome assembly provides a resource for analysing amniote evolution, and highlights the imperative for meaningful cultural engagement with Indigenous communities in genome-sequencing endeavours.

Neil J. Gemmell
Kim Rutherford
Haydn Edmonds
ResearchOpen Access05 Aug 2020
Nature

Volume: 584, P: 403-409
Placentation defects are highly prevalent in embryonic lethal mouse mutants

Analysis of embryonic lethal and sub-viable mouse knockout lines reveals that ablation of many genes affects placental development, and that the occurrence of placental defects is co-associated with abnormal brain, heart and vascular system development.

Vicente Perez-Garcia
Elena Fineberg
Myriam Hemberger
Research14 Mar 2018
Nature

Volume: 555, P: 463-468
Correction: Corrigendum: High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson
Ann M. Flenniken
Maja Bućan Stephen A. Murray
Amendments and Corrections08 Nov 2017
Nature

Volume: 551, P: 398
High-throughput discovery of novel developmental phenotypes

Identification and characterization, using a comprehensive embryonic phenotyping pipeline, of 410 lethal alleles during the generation of the first 1,751 of 5,000 unique gene knockouts produced by the International Mouse Phenotyping Consortium.

Mary E. Dickinson
Ann M. Flenniken
Stephen A. Murray
Research14 Sept 2016
Nature

Volume: 537, P: 508-514
Insights into hominid evolution from the gorilla genome sequence

The genome of a western lowland gorilla has been sequenced and analysed, completing the genome sequences of all great ape genera, and providing evidence for parallel accelerated evolution in chimpanzee, gorilla and human lineages at a number of loci.

Aylwyn Scally
Julien Y. Dutheil
Richard Durbin
ResearchOpen Access07 Mar 2012
Nature

Volume: 483, P: 169-175
Genetic determinants of micronucleus formation in vivo

Genetic screening identifies a rich catalogue of regulators of micronucleus formation.

D. J. Adams
B. Barlas
G. Balmus
ResearchOpen Access14 Feb 2024
Nature

Volume: 627, P: 130-136
A resource of targeted mutant mouse lines for 5,061 genes

The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.

Marie-Christine Birling
Atsushi Yoshiki
Stephen A. Murray
Comments & Opinion08 Apr 2021
Nature Genetics

Volume: 53, P: 416-419
Publisher Correction: The tuatara genome reveals ancient features of amniote evolution

Neil J. Gemmell
Kim Rutherford
Haydn Edmonds
Amendments and CorrectionsOpen Access18 Aug 2020
Nature

Volume: 585, P: E3
Administration and detection of a multi-target rAAV gene doping vector in horses using multiple matrices and molecular techniques

Jillian Maniego
Caitlin Harding
Edward Ryder
Research07 Jul 2024
Gene Therapy

Volume: 31, P: 477-488
Human and mouse essentiality screens as a resource for disease gene discovery

Discovery of causal variants for monogenic disorders has been facilitated by whole exome and genome sequencing, but does not provide a diagnosis for all patients. Here, the authors propose a Full Spectrum of Intolerance to Loss-of-Function (FUSIL) categorization that integrates gene essentiality information to aid disease gene discovery.

Pilar Cacheiro
Violeta Muñoz-Fuentes
Coleen Kane
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-16
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Analysis of the Lung Pathology and Alveolar Macrophage Function in the Acid Sphingomyelinase–Deficient Mouse Model of Niemann-Pick Disease

Rajwinder Dhami
Xingxuan He
Edward H Schuchman
Research01 Jul 2001
Laboratory Investigation

Volume: 81, P: 987-999
Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

Screening mutant mouse lines using a genome-wide in vivo assay identifies microenvironmental regulators of metastatic colonization and defines SPNS2 as an important mediator of lung colonization.

Louise van der Weyden
Mark J. Arends
David J. Adams
Research04 Jan 2017
Nature

Volume: 541, P: 233-236
Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines

Hillary Elrick
Kevin A. Peterson
Lauryl M. J. Nutter
ResearchOpen Access30 Sept 2024
Scientific Reports

Volume: 14, P: 1-15
Screening for gene doping transgenes in horses via the use of massively parallel sequencing

Jillian Maniego
Bogusia Pesko
Edward Ryder
Research19 Jul 2021
Gene Therapy

Volume: 29, P: 236-246
HLA Typing Using DNA Probes

Henry A. Erlich
Edward L. Sheldon
Glenn Horn
Reviews01 Nov 1986
Bio/Technology

Volume: 4, P: 975-981

Search

Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Mechanism of activation of a human oncogene

Chloroplast DNA sequence from a Miocene Magnolia species

Yeast and mammalian ras proteins have conserved biochemical properties

Dense sampling of bird diversity increases power of comparative genomics

Human Propionyl CoA Carboxylase: Some Properties of the Partially Purified Enzyme in Fibroblasts from Controls and Patients with Propionic Acidemia

Common and distinct transcriptional signatures of mammalian embryonic lethality

Author Correction: Dense sampling of bird diversity increases power of comparative genomics

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

The tuatara genome reveals ancient features of amniote evolution

Placentation defects are highly prevalent in embryonic lethal mouse mutants

Correction: Corrigendum: High-throughput discovery of novel developmental phenotypes

High-throughput discovery of novel developmental phenotypes

Insights into hominid evolution from the gorilla genome sequence

Genetic determinants of micronucleus formation in vivo

A resource of targeted mutant mouse lines for 5,061 genes

Publisher Correction: The tuatara genome reveals ancient features of amniote evolution

Administration and detection of a multi-target rAAV gene doping vector in horses using multiple matrices and molecular techniques

Human and mouse essentiality screens as a resource for disease gene discovery

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Analysis of the Lung Pathology and Alveolar Macrophage Function in the Acid Sphingomyelinase–Deficient Mouse Model of Niemann-Pick Disease

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines

Screening for gene doping transgenes in horses via the use of massively parallel sequencing

HLA Typing Using DNA Probes

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