Nature Search

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Many genetic factors that contribute to uterine leiomyomata (UL) - the most common tumours of the female genital tract - remain to be discovered. Here, the authors conduct a UL meta-genome-wide association study, and find loci related to altered muscle tissue biology that are associated with UL.

Eeva Sliz
Jaakko S. Tyrmi
Johannes Kettunen
ResearchOpen Access01 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

A genome-wide association study suggests 41 previously unreported loci on top of the 23 known loci that influence the disease risk for lumbar disc herniations. Many of these loci harbour genes implicated in disc structure and inflammation, as well as genes related to the nervous system and nerve function.

Ville Salo
Juhani Määttä
Johannes Kettunen
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Thickness of the cerebral cortex shows positive association with blood levels of triacylglycerols carrying 18-carbon fatty acids

Eeva Sliz et al. show an association between triacylglycerols species carrying 18-carbon unsaturated fatty acids and cortical thickness by combining serum lipidomics and brain imaging data. This association is more pronounced in cortical regions with higher expression of genes regulating fatty acid metabolism and cellular membranes.

Eeva Sliz
Jean Shin
Zdenka Pausova
ResearchOpen Access20 Aug 2020
Communications Biology

Volume: 3, P: 1-9
Visceral adiposity is associated with metabolic profiles predictive of type 2 diabetes and myocardial infarction

Raheem, Sliz et al. study the serum metabolome and an imaging-based measure of visceral fat in adults and adolescents. The authors find that, independently of BMI, visceral fat quantity is associated with a metabolomic profile similar to those predictive of type 2 diabetes and myocardial infarction.

Javeria Raheem
Eeva Sliz
Zdenka Pausova
ResearchOpen Access01 Jul 2022
Communications Medicine

Volume: 2, P: 1-7
Genetic risk factors underlying white matter hyperintensities and cortical atrophy

White matter hyperintensities are linked to cortical atrophy, a key feature in dementia. Here, the authors identify loci associated with cortical atrophy related to white matter hyperintensities, which involve vascular and neuronal processes.

Yash Patel
Jean Shin
Zdenka Pausova
ResearchOpen Access04 Nov 2024
Nature Communications

Volume: 15, P: 1-11
Genome-wide characterization of circulating metabolic biomarkers

A meta-analysis of genome-wide association studies for 233 circulating metabolites from 33 cohorts reveals more than 400 loci and suggests probable causal genes, providing insights into metabolic pathways and disease aetiology.

Minna K. Karjalainen
Savita Karthikeyan
Johannes Kettunen
ResearchOpen Access06 Mar 2024
Nature

Volume: 628, P: 130-138
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

Meta-analyses of genome-wide association studies for endometriosis identify 49 distinct association signals. Fine-mapping of causal variants explores functional effects across various tissues. Genetic correlations between endometriosis and other pain conditions are also highlighted.

Nilufer Rahmioglu
Sally Mortlock
Krina T. Zondervan
Research13 Mar 2023
Nature Genetics

Volume: 55, P: 423-436
Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media

Argyro Bizaki-Vallaskangas
Joel Rämö
Johannes Kettunen
ResearchOpen Access07 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Narcolepsy has genetic and environmental risk factors, but the specific genetic risk loci and interaction with environmental triggers are not well understood. Here, the authors identify genetic loci for narcolepsy, suggesting infection as a trigger and dendritic and helper T cell involvement.

Hanna M. Ollila
Eilon Sharon
Emmanuel J. Mignot
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-13
Narcolepsy as a potential risk factor for Schizophrenia

Reyhane Eghtedarian
Anniina M. Tervi
Hanna M. Ollila
ResearchOpen Access17 Feb 2025
Translational Psychiatry

Volume: 15, P: 1-10
Novel loci and biomedical consequences of iron homoeostasis variation

The largest meta-analysis of GWASs of hepcidin and sTfR identified 43 genomic loci, of which 15 new. Mendelian randomisation revealed associations of systemic iron status and iron-related loci with selected health outcomes across multiple domains.

Elias Allara
Steven Bell
Emanuele Di Angelantonio
ResearchOpen Access06 Dec 2024
Communications Biology

Volume: 7, P: 1-17
A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents

Eeva Sliz
Jean Shin
Zdenka Pausova
Research03 Jan 2020
Molecular Psychiatry

Volume: 26, P: 3795-3805
NTHL1 is a recessive cancer susceptibility gene

Anna K. Nurmi
Liisa M. Pelttari
Heli Nevanlinna
ResearchOpen Access30 Nov 2023
Scientific Reports

Volume: 13, P: 1-14
A FinnGen pilot clinical recall study for Alzheimer’s disease

Valtteri Julkunen
Claudia Schwarz
Heiko Runz
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-15

Search

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

Thickness of the cerebral cortex shows positive association with blood levels of triacylglycerols carrying 18-carbon fatty acids

Visceral adiposity is associated with metabolic profiles predictive of type 2 diabetes and myocardial infarction

Genetic risk factors underlying white matter hyperintensities and cortical atrophy

Genome-wide characterization of circulating metabolic biomarkers

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Narcolepsy as a potential risk factor for Schizophrenia

Novel loci and biomedical consequences of iron homoeostasis variation

A variant near DHCR24 associates with microstructural properties of white matter and peripheral lipid metabolism in adolescents

NTHL1 is a recessive cancer susceptibility gene

A FinnGen pilot clinical recall study for Alzheimer’s disease

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