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Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation

Here, the authors identify a cognitive reserve-related activity pattern underlying successful memory encoding. They further derive individual reserve scores that predict the maintenance of cognitive performance in the face of Alzheimer’s disease pathology.

Niklas Vockert
Judith Machts
Gabriel Ziegler
ResearchOpen Access13 Nov 2024
Nature Communications

Volume: 15, P: 1-16
Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins

Georgy Berezhnoy
Gyuntae Bae
Christoph Trautwein
ResearchOpen Access22 May 2025
Scientific Reports

Volume: 15, P: 1-20
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Plasma extracellular vesicles contain quantifiable amounts of TDP-43 and full-length tau, allowing the accurate assessment of pathology in frontotemporal dementia, frontotemporal dementia spectrum disorders and amyotrophic lateral sclerosis.

Madhurima Chatterjee
Selcuk Özdemir
Anja Schneider
ResearchOpen Access18 Jun 2024
Nature Medicine

Volume: 30, P: 1771-1783
Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease

David Mengel
Ester Soter
Matthis Synofzik
ResearchOpen Access18 Apr 2025
Molecular Psychiatry

Volume: 30, P: 3150-3159
Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer’s disease

Multiple state-of-the-art analyses of immune cells in 117 blood, 117 cerebrospinal fluid, 13 choroid plexus and 13 brain parenchyma samples reveal differential characteristics of immune cells in different body compartments and different diseases.

Camila Fernández Zapata
Ginevra Giacomello
Chotima Böttcher
ResearchOpen Access23 Nov 2022
Nature Communications

Volume: 13, P: 1-18
Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

Single-cell mass cytometry was applied to comprehensively characterize postmortem and fresh human microglia. Using a hybrid workflow for multidimensional data analysis, a core signature and regional heterogeneity were identified.

Chotima Böttcher
Stephan Schlickeiser
Josef Priller
Research17 Dec 2018
Nature Neuroscience

Volume: 22, P: 78-90
Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects

Bloemeke et al. develop a method for measuring Aβ oligomers in plasma to diagnose Alzheimer’s Disease. Correlation analysis between cerebral spinal fluid and plasma oligomer concentrations indicates an impaired clearance of Aβ oligomers that is dependent on ApoE ε4 status.

Lara Blömeke
Fabian Rehn
Dieter Willbold
ResearchOpen Access10 Dec 2024
Communications Medicine

Volume: 4, P: 1-13
Author Correction: Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease

Filippo Martinelli
Almut Heinken
Ines Thiele
Amendments and CorrectionsOpen Access12 Nov 2024
Scientific Reports

Volume: 14, P: 1
Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease

Filippo Martinelli
Almut Heinken
Ines Thiele
ResearchOpen Access13 Mar 2024
Scientific Reports

Volume: 14, P: 1-14
The BDNF_Val66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease

Nicolai Franzmeier
Jinyi Ren
Michael Ewers
Research21 Mar 2019
Molecular Psychiatry

Volume: 26, P: 614-628

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Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation

Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease

Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer’s disease

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects

Author Correction: Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease

Whole-body metabolic modelling reveals microbiome and genomic interactions on reduced urine formate levels in Alzheimer’s disease

The BDNF_Val66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer’s disease

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