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Therapy for gestational diabetes mellitus—time for a change?

For >30 years, insulin has been the drug of choice for the medical treatment of gestational diabetes mellitus. However, the use of oral hypoglycaemic agents has increased during the past 1–2 decades, so a recent comparison of treatment with glibenclamide, metformin or insulin in women with gestational diabetes mellitus is highly relevant.

Peter Damm
Elisabeth R. Mathiesen
News & Views07 Apr 2015
Nature Reviews Endocrinology

Volume: 11, P: 327-328
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Genome-wide association analyses of two oral glucose tolerance test-derived measures of postprandial insulin resistance discover ten new loci. Functional characterization identifies nine candidate genes implicated in the regulation of GLUT4.

Alice Williamson
Dougall M. Norris
Claudia Langenberg
Research08 Jun 2023
Nature Genetics

Volume: 55, P: 973-983
Managing type 1 diabetes mellitus in pregnancy—from planning to breastfeeding

Pregnant women with type 1 diabetes mellitus have an increased risk of adverse pregnancy outcomes. This Review discusses the importance of preconception counselling and careful monitoring of glucose levels, and describes the use of insulin analogues to maintain tight glycaemic control from pregnancy planning through to breastfeeding.

Lene Ringholm
Elisabeth R. Mathiesen
Peter Damm
Reviews11 Sept 2012
Nature Reviews Endocrinology

Volume: 8, P: 659-667
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Improving pregnancy outcomes in women with diabetes mellitus: modern management

Women with pre-existing diabetes mellitus are at increased risk of complications during pregnancy. This Review outlines the latest management strategies that have been designed to reduce this risk, including diet and pharmacotherapy options.

Lene Ringholm
Peter Damm
Elisabeth R. Mathiesen
Reviews04 Apr 2019
Nature Reviews Endocrinology

Volume: 15, P: 406-416
Mediators of lifestyle intervention effects on neonatal adiposity: are we missing a piece of the puzzle?

Rodrigo Antunes Lima
Gernot Desoye
Judith G. M. Jelsma
Research22 Mar 2021
Pediatric Research

Volume: 91, P: 522-525
Gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is the most common complication in pregnancy and has short-term and long-term effects in both mother and offspring. This Primer discusses the definitions of GDM, diagnosis and management of the disease and areas requiring further research.

H. David McIntyre
Patrick Catalano
Peter Damm
Reviews11 Jul 2019
Nature Reviews Disease Primers

Volume: 5, P: 1-19
Less sedentary time is associated with a more favourable glucose-insulin axis in obese pregnant women—a secondary analysis of the DALI study

Anna M. Dieberger
Gernot Desoye
Mireille N. M. van Poppel
ResearchOpen Access13 Jul 2020
International Journal of Obesity

Volume: 45, P: 296-307

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