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Advanced filters: Author: Elizabeth Lenkiewicz Clear advanced filters

A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer

The epigenetic mechanisms underlying pancreatic ductal adenocarcinoma (PDAC) are not fully elucidated. Here, the authors reveal a druggable super-enhancer-mediated RNA-binding protein cascade that supports PDAC growth through enhanced mRNA translation.

Corina E. Antal
Tae Gyu Oh
Ronald M. Evans
ResearchOpen Access06 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Comprehensive genomic characterization defines human glioblastoma genes and core pathways

With a comprehensive analysis of sequencing data, DNA copy number, gene expression and DNA methylation in a large number of human glioblastomas, The Cancer Genome Atlas project initiative provides a broad overview of the genes and pathways that are altered in this cancer type.

Roger McLendon
Allan Friedman
Elizabeth Thomson
Research04 Sept 2008
Nature

Volume: 455, P: 1061-1068
Unique evolutionary trajectories of breast cancers with distinct genomic and spatial heterogeneity

Tanya N. Phung
Timothy H. Webster
Michael T. Barrett
ResearchOpen Access19 May 2021
Scientific Reports

Volume: 11, P: 1-12
Unique genomic and neoepitope landscapes across tumors: a study across time, tissues, and space within a single lynch syndrome patient

Tanya N. Phung
Elizabeth Lenkiewicz
Michael T. Barrett
ResearchOpen Access22 Jul 2020
Scientific Reports

Volume: 10, P: 1-10
Clinical study of genomic drivers in pancreatic ductal adenocarcinoma

Michael T Barrett
Ray Deiotte
Daniel D Von Hoff
ResearchOpen Access18 Jul 2017
British Journal of Cancer

Volume: 117, P: 572-582