Loss of Y chromosome (LOY), the most commonly occurring post-zygotic (somatic) mutation in male individuals, affects immune activity and is associated with cancer, neurodegeneration, cardiovascular disease and infection. LOY is dynamic over time and has cell-type-specific effects, suggesting its potential as a biomarker and therapeutic target.
- Bozena Bruhn-Olszewska
- Ellen Markljung
- Jan P. Dumanski
