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Showing 1–15 of 15 results

Advanced filters: Author: Emily Kirkpatrick Clear advanced filters

Ageing: Live faster, die younger

People with schizophrenia show signs of accelerated ageing — a phenomenon that could lead researchers to a deeper understanding of the disease.

Emily Anthes
Comments & Opinion02 Apr 2014
Nature

Volume: 508, P: S16-S17
Corrugated megathrust revealed offshore from Costa Rica

Mature parts of the shallow megathrust beneath Costa Rica are characterized by striking corrugations that may channel fluids, according to seismic images. Nascent sections of the subduction zone plate boundary appear only weakly corrugated.

Joel H. Edwards
Jared W. Kluesner
Kristina Okamoto
Research12 Feb 2018
Nature Geoscience

Volume: 11, P: 197-202
Experimental demonstration of attosecond pump–probe spectroscopy with an X-ray free-electron laser

Researchers have demonstrated the generation and control of subfemtosecond pulse pairs from a two-colour X-ray free-electron laser and conducted pump–probe experiments in core-ionized molecules.

Zhaoheng Guo
Taran Driver
Agostino Marinelli
Research11 Apr 2024
Nature Photonics

Volume: 18, P: 691-697
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Cognitive function is associated with health and important life outcomes. Here, the authors perform a genome-wide association study for general cognitive function in 300,486 individuals and identify genetic loci that implicate neural and cell developmental pathways in this trait.

Gail Davies
Max Lam
Ian J. Deary
ResearchOpen Access29 May 2018
Nature Communications

Volume: 9, P: 1-16
Publisher Correction: Corrugated megathrust revealed offshore from Costa Rica

Joel H. Edwards
Jared W. Kluesner
Kristina Okamoto
Amendments and Corrections26 Mar 2018
Nature Geoscience

Volume: 11, P: 375
Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients

In this clinical trial, the authors show that a 5-day molnupiravir treatment reduces SARS-CoV-2 viral load in at-risk outpatients by day 5 but mostly fails to clear virus, leads to lower spike antibody response by day 14 and higher virus mutation rates.

Joseph F. Standing
Laura Buggiotti
Francis Yongblah
ResearchOpen Access23 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

The 3CL protease of SARS-CoV-2 is inhibited by PF-00835231 in vitro. Here, the authors show that the prodrug PF-07304814 has broad spectrum activity, inhibiting SARS-CoV and SARS-CoV-2 in mice and its ADME and safety profile support clinical development.

Britton Boras
Rhys M. Jones
Charlotte Allerton
ResearchOpen Access18 Oct 2021
Nature Communications

Volume: 12, P: 1-17
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions

Here, the authors perform repurposing screens of the ReFRAME drug library in two cell lines and identify inhibitors of SARS-CoV-2 infection. Antiviral activity of prodrug MK-4482 is confirmed in hamsters.

Malina A. Bakowski
Nathan Beutler
Thomas F. Rogers
ResearchOpen Access03 Jun 2021
Nature Communications

Volume: 12, P: 1-14
Fine population structure analysis method for genomes of many

Xuedong Pan
Yi Wang
Li Jin
ResearchOpen Access03 Oct 2017
Scientific Reports

Volume: 7, P: 1-9
Pre-symptomatic detection of COVID-19 from smartwatch data

Analysis of physiological and activity data from consumer smartwatches enables real-time detection, often before symptom onset, of COVID-19, as well as other respiratory illnesses and stress inducers.

Tejaswini Mishra
Meng Wang
Michael P. Snyder
Research18 Nov 2020
Nature Biomedical Engineering

Volume: 4, P: 1208-1220
A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus

Analysis of the FGF14-SCA27B repeat locus identifies a common 5′-flanking insertion that represents the major allele, is present exclusively on nonpathogenic alleles, enhances repeat stability and increases chromatin accessibility.

David Pellerin
Giulia F. Del Gobbo
Matt C. Danzi
Research27 Jun 2024
Nature Genetics

Volume: 56, P: 1366-1370
Can the black box be cracked? The augmentation of microbial ecology by high-resolution, automated sensing technologies

Ashley Shade
Cayelan C Carey
Matthew C Smith
Reviews21 May 2009
The ISME Journal

Volume: 3, P: 881-888
SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms

Ye Wang
Morvarid Mohseni
Silvia Goldoni
ResearchOpen Access14 Jan 2021
Scientific Reports

Volume: 11, P: 1-23
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Rachel L O’Connell
Tim Rattay
Mohammed Mustafa
ResearchOpen Access29 Mar 2019
British Journal of Cancer

Volume: 120, P: 883-895
Bacterial diversity and community composition from seasurface to subseafloor

Emily A Walsh
John B Kirkpatrick
Steven D'Hondt
ResearchOpen Access02 Oct 2015
The ISME Journal

Volume: 10, P: 979-989