Nature Search

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

The high degree of subtype plasticity in small cell lung cancer (SCLC) poses a therapeutic challenge. Here, the authors show that the non-neuroendocrine (non-NE) subtype of SCLC is sensitive to ferroptosis while the neuroendocrine (NE) subtype is vulnerable to TRX anti-oxidant pathway inhibition, and the combination of these two treatments in SCLC circumvents non-NE/NE subtype plasticity.

Christina M. Bebber
Emily S. Thomas
Silvia von Karstedt
ResearchOpen Access06 Apr 2021
Nature Communications

Volume: 12, P: 1-19
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

The cellular organelles peroxisomes contribute to the sensitivity of cells to ferroptosis by synthesizing polyunsaturated ether phospholipids, and changes in the abundances of these lipids are associated with altered sensitivity to ferroptosis during cell-state transitions.

Yilong Zou
Whitney S. Henry
Stuart L. Schreiber
Research16 Sept 2020
Nature

Volume: 585, P: 603-608
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8⁺ thymocytes

The thymus harbors a complex constitutively active inflammatory network with innate-like T cells representing one of its central nodes. Here, the authors show that these cells can induce tolerance to inflammation-associated self-antigens, a class of molecules that otherwise largely mirrors the spatial and temporal distribution of pathogen-derived antigens.

Yuanyuan You
Josefine Dunst
Taras Kreslavsky
ResearchOpen Access11 Jul 2024
Nature Immunology

Volume: 25, P: 1367-1382
Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment

The use of biomaterial scaffolds-based cartilage grafts could potentially innovate the Osteoarthritis (OA) treatment, but has been limited by toxicity concerns and invasive surgical procedures. Here, the authors report an injectable and biodegradable piezoelectric hydrogel with ultrasound activation to offer a minimally invasive approach for OA treatment.

Tra Vinikoor
Godwin K. Dzidotor
Thanh D. Nguyen
ResearchOpen Access06 Oct 2023
Nature Communications

Volume: 14, P: 1-18
Automatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress

Accurate phenotyping is key to deciphering behavior. Here, authors show the utility of the software package DeepOF in supervised and unsupervised identification of distinct individual and social behavioral patterns following chronic social stress.

Joeri Bordes
Lucas Miranda
Mathias V. Schmidt
ResearchOpen Access18 Jul 2023
Nature Communications

Volume: 14, P: 1-19
Unique features of a global human ectoparasite identified through sequencing of the bed bug genome

The bed bug, Cimex lectularius, is a ubiquitous human ectoparasite with global distribution. Here, the authors sequence the genome of the bed bug and identify reductions in chemosensory genes, expansion of genes associated with blood digestion and genes linked to pesticide resistance.

Joshua B. Benoit
Zach N. Adelman
Stephen Richards
ResearchOpen Access02 Feb 2016
Nature Communications

Volume: 7, P: 1-10
Erratum: Genome analysis of the platypus reveals unique signatures of evolution

Wesley C. Warren
LaDeana W. Hillier
Richard K. Wilson
Amendments and Corrections11 Sept 2008
Nature

Volume: 455, P: 256
Genome analysis of the platypus reveals unique signatures of evolution

Platypuses are monotremes and combine aspects of both reptilian and mammalian behaviour. An international consortium reports the genome sequence and analysis of Ornithorhynchus anatinus and as expected, parts of the genome look more like mammals, whereas other parts more like reptiles or even chickens.

Wesley C. Warren
LaDeana W. Hillier
Richard K. Wilson
ResearchOpen Access08 May 2008
Nature

Volume: 453, P: 175-183
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

Isoform B of the chromatin-binding protein Brd4 acts to suppress DNA damage response signalling.

Scott R. Floyd
Michael E. Pacold
Michael B. Yaffe
Research02 Jun 2013
Nature

Volume: 498, P: 246-250
B cells oppose Mycoplasma pneumoniae vaccine enhanced disease and limit bacterial colonization of the lungs

Tyler D. Gavitt
Arlind B. Mara
Steven M. Szczepanek
ResearchOpen Access31 Oct 2022
npj Vaccines

Volume: 7, P: 1-13
Vaccination with Mycoplasma pneumoniae membrane lipoproteins induces IL-17A driven neutrophilia that mediates Vaccine-Enhanced Disease

Arlind B. Mara
Tyler D. Gavitt
Steven J. Geary
ResearchOpen Access29 Jul 2022
npj Vaccines

Volume: 7, P: 1-14
Tissue engineered vascular grafts transform into autologous neovessels capable of native function and growth

Blum et al. combine computational and experimental methods to study the long-term development of tissue engineered vascular grafts in a lamb model. The authors demonstrate that the grafts undergo growth and remodeling, evolving to mimic the characteristics and function of a native blood vessel.

Kevin M. Blum
Jacob C. Zbinden
Christopher K. Breuer
ResearchOpen Access10 Jan 2022
Communications Medicine

Volume: 2, P: 1-21

Search

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8⁺ thymocytes

Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment

Automatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress

Unique features of a global human ectoparasite identified through sequencing of the bed bug genome

Erratum: Genome analysis of the platypus reveals unique signatures of evolution

Genome analysis of the platypus reveals unique signatures of evolution

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

B cells oppose Mycoplasma pneumoniae vaccine enhanced disease and limit bacterial colonization of the lungs

Vaccination with Mycoplasma pneumoniae membrane lipoproteins induces IL-17A driven neutrophilia that mediates Vaccine-Enhanced Disease

Tissue engineered vascular grafts transform into autologous neovessels capable of native function and growth

Search

Quick links

Search

Filter By:

Search

Quick links