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Showing 1–10 of 10 results
Advanced filters: Author: Emmanouela Repapi Clear advanced filters
  • Mathematical tools can be used to help identify pathological features from images of diseased lungs. Here, the authors used mathematical tools combined with high resolution multiplex imaging mass cytometry to show an association between immature neutrophils, CD8 T cells and proliferating alveolar epithelial cells in areas of maximal alveolar damage in COVID-19 lungs.

    • Praveen Weeratunga
    • Laura Denney
    • Ling-Pei Ho
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20
  • Histone 3 lysine 79 is mono (me1), di (me2), or tri (me3) methylated by the methyltransferase DOT1L. Here the authors reveal a group of enhancers defined by H3K79me2/3 which regulates enhancer-promoter interactions and other key enhancer features in MLL-AF4 leukemia cells.

    • Laura Godfrey
    • Nicholas T. Crump
    • Thomas A. Milne
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15
  • The chromatin remodeling complex ATRX can promote gene expression, for example by binding G-quadruplexes (G4s) to prevent their negative effect on expression. Here the authors use a single-cell approach to show that only a subset of erythroid cells isolated from patients with ATRX mutations have reduced chromatin accessibility and alpha globin expression, suggesting a stochastic process.

    • Julia Truch
    • Damien J. Downes
    • Richard J. Gibbons
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16
  • The role of BRD4 and Mediator in regulating enhancer-promoter interactions is poorly understood. Here the authors find that treatment with BET inhibitors or pharmacological degradation of BRD4 disrupts transcription while having very little effect on enhancer-promoter interactions.

    • Nicholas T. Crump
    • Erica Ballabio
    • Thomas A. Milne
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15
  • Multimodal single-cell profiling reveals heterogeneity of colonic CD8+ T cells in patients with ulcerative colitis, including expansion of a chronically activated IL-26-expressing subpopulation with innate-like features.

    • Daniele Corridoni
    • Agne Antanaviciute
    • Alison Simmons
    Research
    Nature Medicine
    Volume: 26, P: 1480-1490
  • Mechanisms that operate during embryonic development to restrict cell fate are currently under investigation. Here the authors characterise the role of SCL/TAL1 at the onset of blood specification in embryonic development using mouse EB differentiation culture as a model system.

    • Hedia Chagraoui
    • Maiken S. Kristiansen
    • Catherine Porcher
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17
  • Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.

    • Sant-Rayn Pasricha
    • Pei Jin Lim
    • Hal Drakesmith
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15