Nature Search

Accurate compound-specific ¹⁴C dating of archaeological pottery vessels

Using lipid residues absorbed in potsherds, the ages of pottery from various archaeological sites are determined and validated using sites for which the dates are well known from other methods.

Emmanuelle Casanova
Timothy D. J. Knowles
Richard P. Evershed
Research08 Apr 2020
Nature

Volume: 580, P: 506-510
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

Tom Le Voyer
Audrey V. Parent
Anne Puel
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 803-813
Diverse prehistoric cattle husbandry strategies in the forests of Central Europe

Stable isotope analysis of zooarchaeological remains and pottery in a palaeo-environmental framework reveals that early Central European farmers utilized diverse regional pasturing strategies for cattle, including the use of forested environments for grazing and seasonal foddering.

Rosalind E. Gillis
Iain P. Kendall
Richard P. Evershed
ResearchOpen Access29 Oct 2024
Nature Ecology & Evolution

Volume: 9, P: 87-98
Tuberculosis in otherwise healthy adults with inherited TNF deficiency

Human TNF is required for respiratory-burst-dependent immunity to Mycobacterium tuberculosis in macrophages but seems to be largely redundant physiologically.

Andrés A. Arias
Anna-Lena Neehus
Stéphanie Boisson-Dupuis
ResearchOpen Access28 Aug 2024
Nature

Volume: 633, P: 417-425
Erratum: Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

Xianqin Zhang
Dusan Bogunovic
Sandra Pellegrini
Amendments and Corrections11 Feb 2015
Nature

Volume: 519, P: 378
Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency

Stéphanie Dupuis
Emmanuelle Jouanguy
Jean-Laurent Casanova
Research18 Feb 2003
Nature Genetics

Volume: 33, P: 388-391
Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?

Why do some young and previously healthy individuals develop severe COVID-19? In this Comment, Casanova and colleagues suggest that monogenic inborn errors of immunity may be responsible based on lessons from other viral infections.

Shen-Ying Zhang
Qian Zhang
Luigi Notarangelo
Comments & Opinion18 Jun 2020
Nature Reviews Immunology

Volume: 20, P: 455-456
Dairying, diseases and the evolution of lactase persistence in Europe

Examination of archaeological pottery residues and modern genes suggest that environmental conditions, subsistence economics and pathogen exposure may explain selection for lactase persistence better than prehistoric consumption of milk.

Richard P. Evershed
George Davey Smith
Mark G. Thomas
Research27 Jul 2022
Nature

Volume: 608, P: 336-345
A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection

Emmanuelle Jouanguy
Salma Lamhamedi-Cherradi
Jean-Laurent Casanova
Research01 Apr 1999
Nature Genetics

Volume: 21, P: 370-378
Tree-rings reveal two strong solar proton events in 7176 and 5259 BCE

Two extreme solar energetic particle events have been found by carbon isotopes measured in ancient tree rings in 7176 and 5259 BCE. The recorded ~2% increases of atmospheric 14 C for both events exceeds in amplitude of all previously observed events.

Nicolas Brehm
Marcus Christl
Lukas Wacker
ResearchOpen Access07 Mar 2022
Nature Communications

Volume: 13, P: 1-8
A virus finds its natural killer

It has been suggested that natural killer (NK) cells contribute to host defense against infections, but genetic evidence has been lacking. A new study of mouse strains susceptible to infection by cytomegalovirus indicates that the Klra8 (formerly Ly49H) stimulatory receptor is essential to resisting the virus. Such a receptor may have evolved as a response of NK cells to viral strategies to evade the immune system.

Jean-Laurent Casanova
Emmanuelle Jouanguy
Laurent Abel
News & Views01 May 2001
Nature Genetics

Volume: 28, P: 7-9
Chemical evidence of dairying by hunter-gatherers in highland Lesotho in the late first millennium ad

Fewlass et al. recover dairy residues from hunter-gatherer pottery from highland Lesotho dating from mid-to-late first millennium ad, which implies ongoing contact between these groups and coastal agriculturalists not long after they first arrived in southern Africa.

Helen Fewlass
Peter J. Mitchell
Lucy J. E. Cramp
Research11 May 2020
Nature Human Behaviour

Volume: 4, P: 791-799
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

ISG15 deficiency in humans leads to a failure to maintain adequate levels of USP18, triggering an increase in type I interferon production and signalling, and promoting auto-inflammatory disease.

Xianqin Zhang
Dusan Bogunovic
Sandra Pellegrini
Research12 Oct 2014
Nature

Volume: 517, P: 89-93
Author Correction: Dairying, diseases and the evolution of lactase persistence in Europe

Richard P. Evershed
George Davey Smith
Mark G. Thomas
Amendments and Corrections30 Aug 2022
Nature

Volume: 609, P: E9
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

Neurons and oligodendrocytes differentiated from induced pluripotent stem cells (iPSCs) of patients with inherited TLR3 and UNC-93B deficiencies are found to be more susceptible to infection by HSV-1 than control cells because they fail to induce a normal interferon response, whereas neural stem cells and astrocytes are not susceptible.

Fabien G. Lafaille
Itai M. Pessach
Luigi D. Notarangelo
Research28 Oct 2012
Nature

Volume: 491, P: 769-773
Author Correction: A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

Evangelos Andreakos
Laurent Abel
András N. Spaan
Amendments and Corrections24 Nov 2021
Nature Immunology

Volume: 23, P: 341
Human genetic and immunological determinants of critical COVID-19 pneumonia

The COVID Human Genetic Effort examines the molecular, cellular and immunological determinants of the various SARS-CoV-2-related disease manifestations by searching for causal errors of immunity.

Qian Zhang
Paul Bastard
Jean-Laurent Casanova
Reviews28 Jan 2022
Nature

Volume: 603, P: 587-598
Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness

Marina Cavazzana-Calvo and colleagues report mutations in the gene encoding mitochondrial adenylate kinase 2 in reticular dysgenesis, the most severe form of inborn combined immunodeficiency, characterized by the absence of granulocytes and almost complete deficiency of lymphocytes in peripheral blood.

Chantal Lagresle-Peyrou
Emmanuelle M Six
Marina Cavazzana-Calvo
Research30 Nov 2008
Nature Genetics

Volume: 41, P: 106-111
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

In this Perspective, Spaan and colleagues propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.

Evangelos Andreakos
Laurent Abel
András N. Spaan
Reviews18 Oct 2021
Nature Immunology

Volume: 23, P: 159-164
Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery

Joseph Gleeson and colleagues report whole-exome sequencing of a cohort of over 1,000 individuals from the Greater Middle East, characterizing common and rare variants. They find evidence of subregional diversity and historical migrations and use the GME Variome to identify disease-causing mutations.

Eric M Scott
Anason Halees
Joseph G Gleeson
Research18 Jul 2016
Nature Genetics

Volume: 48, P: 1071-1076
Four millennia of dairy surplus and deposition revealed through compound-specific stable isotope analysis and radiocarbon dating of Irish bog butters

Jessica Smyth
Robert Berstan
Richard P. Evershed
ResearchOpen Access14 Mar 2019
Scientific Reports

Volume: 9, P: 1-10
Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells

Simon Body
Anna Esteve-Arenys
Brigitte Sola
ResearchOpen Access24 Oct 2017
Scientific Reports

Volume: 7, P: 1-12
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Accurate compound-specific ¹⁴C dating of archaeological pottery vessels

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Diverse prehistoric cattle husbandry strategies in the forests of Central Europe

Tuberculosis in otherwise healthy adults with inherited TNF deficiency

Erratum: Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency

Severe COVID-19 in the young and healthy: monogenic inborn errors of immunity?

Dairying, diseases and the evolution of lactase persistence in Europe

A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection

Tree-rings reveal two strong solar proton events in 7176 and 5259 BCE

A virus finds its natural killer

Chemical evidence of dairying by hunter-gatherers in highland Lesotho in the late first millennium ad

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

Author Correction: Dairying, diseases and the evolution of lactase persistence in Europe

A second update on mapping the human genetic architecture of COVID-19

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

Author Correction: A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

Human genetic and immunological determinants of critical COVID-19 pneumonia

Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery

Four millennia of dairy surplus and deposition revealed through compound-specific stable isotope analysis and radiocarbon dating of Irish bog butters

Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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