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Showing 1–7 of 7 results
Advanced filters: Author: Encarnacion Montecino-Rodriguez Clear advanced filters

  • As a result of advances in medicine, public-health policies and socioeconomic development, we are living longer than ever before. Here, the authors describe how ageing affects immune function and discuss the potential of different therapies to slow or reverse this process in the elderly population.

    • Kenneth Dorshkind
    • Encarnacion Montecino-Rodriguez
    • Robert A. J. Signer
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 9, P: 57-62

  • Common lymphoid progenitor cells are the earliest lymphoid progenitor cells assumed to give rise to B and T lineages. The identification of a novel early T lineage progenitor now challenges this model.

    • Encarnacion Montecino-Rodriguez
    • Kenneth Dorshkind
    News & Views
    Nature Immunology
    Volume: 4, P: 100-101

  • B-1 cells are a minor population of B cells that function as effectors of innate immune responses in serous cavities. But where and when do they first emerge in the developing embryo? And do they originate from a distinct progenitor?

    • Kenneth Dorshkind
    • Encarnacion Montecino-Rodriguez
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 213-219

  • As we age, haematopoiesis becomes skewed towards myelopoiesis. Studies of haematopoietic stem cells (HSCs) transplanted into irradiated recipient mice imply that HSC defects are responsible for this ageing effect. Here, the authors urge caution when using irradiated mice to study haematopoiesis ageing, and propose instead that age-related changes in the bone marrow environment and in downstream progenitors, not just HSCs, may also be responsible for myeloid skewing.

    • Kenneth Dorshkind
    • Thomas Höfer
    • Hans-Reimer Rodewald
    Reviews
    Nature Reviews Immunology
    Volume: 20, P: 196-202