Nature Search

Genetic insights into resting heart rate and its role in cardiovascular disease

The genetics and clinical consequences of resting heart rate (RHR) remain incompletely understood. Here, the authors discover new genetic variants associated with RHR and find that higher genetically predicted RHR decreases risk of atrial fibrillation and ischemic stroke.

Yordi J. van de Vegte
Ruben N. Eppinga
Pim van der Harst
ResearchOpen Access02 Aug 2023
Nature Communications

Volume: 14, P: 1-21
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.

Tuomas O. Kilpeläinen
Amy R. Bentley
Ruth J. F. Loos
ResearchOpen Access22 Jan 2019
Nature Communications

Volume: 10, P: 1-11
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction

Glucose availability is limiting in tumor environments. Zou and colleagues show that reduced glycolytic metabolism in T cells within tumors suppresses expression of the methyltransferase EZH2, which limits production of antitumor effector molecules and enhances T cell apoptosis.

Ende Zhao
Tomasz Maj
Weiping Zou
Research02 Nov 2015
Nature Immunology

Volume: 17, P: 95-103
Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

The role of therapy in shaping the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) remains to be explored. Here, the authors perform single-cell RNA sequencing in PDAC samples before and after chemotherapy and suggest that chemotherapy may promote resistance to immunotherapy.

Gregor Werba
Daniel Weissinger
Diane M. Simeone
ResearchOpen Access13 Feb 2023
Nature Communications

Volume: 14, P: 1-16
Author Correction: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Gregor Werba
Daniel Weissinger
Diane M. Simeone
Amendments and CorrectionsOpen Access03 Jul 2023
Nature Communications

Volume: 14, P: 1
Targeting pancreatic cancer metabolic dependencies through glutamine antagonism

Kimmelman and colleagues show that inhibition of glutamine (Gln) metabolism using a Gln antagonist decreases pancreatic cancer tumor growth, but is compensated by upregulation of extracellular signal-regulated kinase signaling, which can be co-targeted.

Joel Encarnación-Rosado
Albert S. W. Sohn
Alec C. Kimmelman
ResearchOpen Access09 Oct 2023
Nature Cancer

Volume: 5, P: 85-99
Epigenetic silencing of T_H1-type chemokines shapes tumour immunity and immunotherapy

Treating ovarian cancer in mouse models with inhibitors for the epigenetic regulators EZH2 and DNMT1 increases the expression of the inflammatory chemokines CXCL9 and CXCL10, resulting in enhanced tumour infiltration by effector T cells, and slowed tumour progression.

Dongjun Peng
Ilona Kryczek
Weiping Zou
Research26 Oct 2015
Nature

Volume: 527, P: 249-253
LncRNA SEMA3B-AS1 inhibits breast cancer progression by targeting miR-3940/KLLN axis

Jin Hu
Haohao Huang
Lei Li
ResearchOpen Access19 Sept 2022
Cell Death & Disease

Volume: 13, P: 1-15
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Lisa de las Fuentes
Yun Ju Sung
Myriam Fornage
Research05 May 2020
Molecular Psychiatry

Volume: 26, P: 2111-2125
Bone marrow and the control of immunity

Ende Zhao
Huanbin Xu
Weiping Zou
Reviews24 Oct 2011
Cellular & Molecular Immunology

Volume: 9, P: 11-19

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