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Increased risk of cardiovascular disease and chronic kidney disease in NAFLD

NAFLD, cardiovascular disease (CVD) and chronic kidney disease (CKD) are thought to be linked. However, whether NAFLD is a marker of, or a causal risk factor for, CVD and CKD is unclear. In this Review, Enzo Bonora and Giovanni Targher discuss the key pitfalls and main certainties surrounding the associations between these diseases.

Enzo Bonora
Giovanni Targher
Reviews08 May 2012
Nature Reviews Gastroenterology & Hepatology

Volume: 9, P: 372-381
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

The rare loss-of-function allele p.Arg138* in SLC30A8 (encoding ZnT8) mediates protection against type 2 diabetes (T2D) through promoting better insulin secretion and enhanced glucose responsiveness, suggesting ZnT8 as a target for T2D treatment.

Om Prakash Dwivedi
Mikko Lehtovirta
Leif Groop
Research01 Nov 2019
Nature Genetics

Volume: 51, P: 1596-1606
Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus

Stefan Kiechl and colleagues show that blockade of receptor activator of nuclear factor-κB (RANKL) signaling in hepatocytes by cell type–specific genetic deletion of its receptor promotes greater insulin sensitivity in both a genetic and a nutritional model of type 2 diabetes. They also show epidemiological evidence that elevated serum concentrations of soluble RANKL are a risk factor for the development of this disease.

Stefan Kiechl
Jürgen Wittmann
Georg Schett
Research10 Feb 2013
Nature Medicine

Volume: 19, P: 358-363
A Novel Insulin/Glucose Model after a Mixed-Meal Test in Patients with Type 1 Diabetes on Insulin Pump Therapy

Luca Marchetti
Federico Reali
Corrado Priami
ResearchOpen Access08 Nov 2016
Scientific Reports

Volume: 6, P: 1-9

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Increased risk of cardiovascular disease and chronic kidney disease in NAFLD

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus

A Novel Insulin/Glucose Model after a Mixed-Meal Test in Patients with Type 1 Diabetes on Insulin Pump Therapy

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