Nature Search

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states

Panzeri et al. use a Trim28^+/D9 mouse model with intrinsic developmental heterogeneity to show that ‘heavy’ and ‘light’ developmental morphs exhibit different timing, type and severity of cancer, linked to a relevant DNA hypomethylation signature.

Ilaria Panzeri
Luca Fagnocchi
John Andrew Pospisilik
ResearchOpen Access24 Jan 2025
Nature Cancer

Volume: 6, P: 385-403
Effectiveness of bariatric metabolic surgery versus glucagon-like peptide-1 receptor agonists for prevention of congestive heart failure

In a retrospective study of individuals living with diabetes and obesity, conducted from 2008 through 2021, treatment with bariatric metabolic surgery was more effective than treatment with GLP-1 receptor agonists for prevention of incident congestive heart failure.

Yael Wolff Sagy
Gil Lavie
Dror Dicker
Research15 May 2024
Nature Medicine

Volume: 30, P: 2337-2342
Melanoma miRNA trafficking controls tumour primary niche formation

Dror et al. report that melanoma-derived melanosomes carry miRNAs that induce primary fibroblast reprogramming into cancer-associated fibroblasts, and also induce the formation of a pro-tumorigenic niche.

Shani Dror
Laureen Sander
Carmit Levy
Research22 Aug 2016
Nature Cell Biology

Volume: 18, P: 1006-1017
IL-1β promotes adipogenesis by directly targeting adipocyte precursors

The consequences of postprandial IL-1β surges in white adipose tissue are unknown. Here the authors show IL-1β regulates WAT remodelling by promoting adipogenesis and energy storage, which is blocked by chronic elevation of this cytokine (as in obesity).

Kaisa Hofwimmer
Joyce de Paula Souza
Jurga Laurencikiene
ResearchOpen Access11 Sept 2024
Nature Communications

Volume: 15, P: 1-18
Spin-valley Rashba monolayer laser

The authors introduce a spin-optical laser based on a monolayer transition metal dichalcogenide coupled to a heterostructure microcavity supporting high-Q spin-valley resonances originating from photonic Rashba-type spin splitting of a bound state in the continuum.

Kexiu Rong
Xiaoyang Duan
Erez Hasman
Research06 Jul 2023
Nature Materials

Volume: 22, P: 1085-1093
Independent phenotypic plasticity axes define distinct obesity sub-types

Yang et al. show that neuronatin (NNAT) can explain part of the phenotypic variation of complex traits, independently of genetics or the environment. Such NNAT-dependent variations can stratify human cohorts into four metabolic sub-types, including two distinct types of obesity.

Chih-Hsiang Yang
Luca Fagnocchi
J. Andrew Pospisilik
ResearchOpen Access12 Sept 2022
Nature Metabolism

Volume: 4, P: 1150-1165
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation

The cytokine IL-1β has well-established harmful effects on pancreatic islet function. Donath and colleagues identify an acute wave of postprandial IL-1β release and show that this unexpectedly has a positive effect on insulin secretion and the maintenance of normal metabolic function.

Erez Dror
Elise Dalmas
Marc Y Donath
Research16 Jan 2017
Nature Immunology

Volume: 18, P: 283-292
Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance

Alexis Ruiz
Erez Dror
Francesco Zorzato
ResearchOpen Access12 Jan 2018
Scientific Reports

Volume: 8, P: 1-14
Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes

Friederike Schulze
Josua Wehner
Marc Y. Donath
ResearchOpen Access20 Feb 2020
Scientific Reports

Volume: 10, P: 1-11
The Role of Inflammation in β-cell Dedifferentiation

Thierry M. Nordmann
Erez Dror
Marc Y. Donath
ResearchOpen Access24 Jul 2017
Scientific Reports

Volume: 7, P: 1-10

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