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Showing 1–10 of 10 results
Advanced filters: Author: Eric Lieberman Greer Clear advanced filters

  • Recent studies have changed our understanding of the prevalence and biological significance of DNAN6-adenine methylation (6mA) in eukaryotes. This modification is involved in regulating transcription, transposable elements and epigenetic inheritance, and thus can be considered to be a eukaryotic epigenetic mark.

    • Guan-Zheng Luo
    • Mario Andres Blanco
    • Yang Shi
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 705-710

  • Mating is known to accelerate the aging of the opposite sex in a variety of species. A transcriptomic analysis of extracted germlines from mated and unmated Caenorhabditis elegans by Shi and Murphy now identifies a Piwi-interacting RNA-to-Hedgehog signaling pathway that regulates the accelerated aging of hermaphrodites.

    • Eric Lieberman Greer
    News & Views
    Nature Aging
    Volume: 3, P: 7-8

  • Boulias and Greer review the functions of N6-methyladenosine (m6A) in RNA at the molecular, genomic and organismal level. They describe the impact of m6A deposition on RNA substrates, chromatin architecture, epigenetic regulation of gene expression and genome stability, as well as key roles of m6A in stem-cell differentiation, neurogenesis and immunity.

    • Konstantinos Boulias
    • Eric Lieberman Greer
    Reviews
    Nature Reviews Genetics
    Volume: 24, P: 143-160

  • In this Review, Boulias and Greer provide an overview of current approaches for detecting and mapping N6-methyl-2′-deoxyadenosine (6mA or m6dA), and discuss the evidence for its presence and functional importance in the genomes of multicellular eukaryotes.

    • Konstantinos Boulias
    • Eric Lieberman Greer
    Reviews
    Nature Reviews Genetics
    Volume: 23, P: 411-428

  • The CNV analysis group of the Psychiatric Genomic Consortium analyzes a large schizophrenia cohort to examine genomic copy number variants (CNVs) and disease risk. They find an enrichment of CNV burden in cases versus controls and identify 8 genome-wide significant loci as well as novel suggestive loci conferring either risk or protection to schizophrenia.

    • Christian R Marshall
    • Daniel P Howrigan
    • Jonathan Sebat
    Research
    Nature Genetics
    Volume: 49, P: 27-35

  • It is shown here that the methylation of histone proteins regulates lifespan in Caenorhabditis elegans. Deficiencies in members of the ASH-2 complex, which trimethylates histone H3 at lysine 4 (H3K4), extend worm lifespan. Meanwhile, the H3K4 demethylase RBR-2 is required for normal lifespan. These findings are consistent with the idea that an excess of H3K4 trimethylation reduces longevity. The extension of lifespan caused by ASH-2 deficiency requires an intact adult germline and the continuous production of mature eggs.

    • Eric L. Greer
    • Travis J. Maures
    • Anne Brunet
    Research
    Nature
    Volume: 466, P: 383-387

  • A recent study performed directed C5-cytosine methylation of CpG islands to demonstrate that acquired methylation at critical loci could be reestablished for multiple generations in mice. This work provides a manipulatable system to examine how non-genetic information is transmitted across generations to regulate complex phenotypes.

    • Gautam Sarkar
    • Eric Lieberman Greer
    News & Views
    Lab Animal
    Volume: 52, P: 105-107