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Advanced filters: Author: Erik Verner Clear advanced filters

Prolonged and tunable residence time using reversible covalent kinase inhibitors

Structural changes in the capping groups of inverted cyanoacrylamide-based kinase inhibitors resulted in alterations in residence time, with some compounds exhibiting sustained pharmacological effects in vivo.

J Michael Bradshaw
Jesse M McFarland
Jack Taunton
Research25 May 2015
Nature Chemical Biology

Volume: 11, P: 525-531
Synthesis and characterization of soquelitinib a selective ITK inhibitor that modulates tumor immunity

Lih-Yun Hsu
James T. Rosenbaum
Richard A. Miller
ResearchOpen Access04 Dec 2024
npj Drug Discovery

Volume: 1, P: 1-14

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Prolonged and tunable residence time using reversible covalent kinase inhibitors

Synthesis and characterization of soquelitinib a selective ITK inhibitor that modulates tumor immunity

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