Nature Search

Off-target response to decoy oligodeoxynucleotide treatment

Ewan Robson
Aaron Jeffs
Michael Eccles
ResearchOpen Access10 Sept 2008
Nature Precedings

P: 1
Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays

Sydney Brenner
Maria Johnson
Kevin Corcoran
Research01 Jun 2000
Nature Biotechnology

Volume: 18, P: 630-634
Genomic basis for RNA alterations in cancer

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Claudia Calabrese
Natalie R. Davidson
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature

Volume: 578, P: 129-136
The co-occurrence of genetic variants in the TYR and OCA2 genes confers susceptibility to albinism

This study demonstrates that the co-occurrence of two specific variants in the TYR and OCA2 genes significantly increases the likelihood of having albinism. The outlined approach could help to elucidate digenic/oligogenic patterns in other rare conditions.

David J. Green
Vincent Michaud
Panagiotis I. Sergouniotis
ResearchOpen Access30 Sept 2024
Nature Communications

Volume: 15, P: 1-10
The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA

The globally-distributed Ranidae (true frogs) are the largest frog family. Here, Hammond et al. present a draft genome of the North American bullfrog, Rana (Lithobates) catesbeiana, as a foundation for future understanding of true frog genetics as amphibian species face difficult environmental challenges.

S. Austin Hammond
René L. Warren
Inanc Birol
ResearchOpen Access10 Nov 2017
Nature Communications

Volume: 8, P: 1-8
Emergence of methicillin resistance predates the clinical use of antibiotics

Methicillin-resistant strains of Staphylococcus aureus appeared in European hedgehogs in the pre-antibiotic era as a co-evolutionary adaptation to antibiotic-producing dermatophytes and have spread within the local hedgehog populations and between hedgehogs and secondary hosts.

Jesper Larsen
Claire L. Raisen
Anders R. Larsen
ResearchOpen Access05 Jan 2022
Nature

Volume: 602, P: 135-141
The landscape of viral associations in human cancers

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Marc Zapatka
Ivan Borozan
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 320-330
Sense from sequence reads: methods for alignment and assembly

Paul Flicek
Ewan Birney
Reviews15 Oct 2009
Nature Methods

Volume: 6, P: S6-S12
RNA modifications detection by comparative Nanopore direct RNA sequencing

Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data.

Adrien Leger
Paulo P. Amaral
Tony Kouzarides
ResearchOpen Access10 Dec 2021
Nature Communications

Volume: 12, P: 1-17
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

An inability to estimate absolute DNA methylation levels has slowed progress in understanding the role of this epigenetic modification in health and disease. Down et al. describe an algorithm for analyzing methylated DNA immunoprecipitation profiles generated using either high-throughput sequencing or oligonucleotide arrays.

Thomas A Down
Vardhman K Rakyan
Stephan Beck
Research08 Jul 2008
Nature Biotechnology

Volume: 26, P: 779-785
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

Recent studies using in depth DNA sequencing techniques led to the identification of cancer driver genes but mainly focused on the effect on their expression. Here, the authors analyse 266 cases of breast cancer and report gene expression signatures associated with the number and character of signature mutations.

Marcel Smid
F. Germán Rodríguez-González
John W. M. Martens
ResearchOpen Access26 Sept 2016
Nature Communications

Volume: 7, P: 1-9
The contribution of common regulatory and protein-coding TYR variants to the genetic architecture of albinism

Albinism is a rare disorder often caused by high-effect rare variants in the TYR gene. Here, the authors study a large albinism cohort and find that a common variant in the TYR promoter contributes to albinism by modifying the penetrance of other common variants, demonstrating a complex genetic architecture.

Vincent Michaud
Eulalie Lasseaux
Panagiotis I. Sergouniotis
ResearchOpen Access08 Jul 2022
Nature Communications

Volume: 13, P: 1-8
Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes

Plasmodium malariae is a cause of malaria in humans and related species have been identified in non-human primates. Here, the authors use genomic analyses to establish that human P. malariae arose from a host switch of an ape parasite whilst a species infecting New World monkeys can be traced to a reverse zoonosis.

Lindsey J. Plenderleith
Weimin Liu
Paul M. Sharp
ResearchOpen Access06 Apr 2022
Nature Communications

Volume: 13, P: 1-12
Comparative genomics: genome-wide analysis in metazoan eukaryotes

Abel Ureta-Vidal
Laurence Ettwiller
Ewan Birney
Reviews01 Apr 2003
Nature Reviews Genetics

Volume: 4, P: 251-262
A universal programmable Gaussian boson sampler for drug discovery

This study develops a programmable quantum processor, named Abacus, and applies it to Gaussian boson sampling tasks targeting drug discovery challenges.

Shang Yu
Zhi-Peng Zhong
Guang-Can Guo
ResearchOpen Access12 Oct 2023
Nature Computational Science

Volume: 3, P: 839-848
The flotation of magmatic sulfides transfers Cu-Au from magmas to seafloor massive sulfide deposits

The flotation of sulfide-bubble compounds in magmas plays an important role in forming Cu-Au hydrothermal seafloor ore deposits, according to petrographic observations, geochemical and physical modeling.

Aurélien Jeanvoine
Jung-Woo Park
Yves Fouquet
ResearchOpen Access27 Aug 2024
Communications Earth & Environment

Volume: 5, P: 1-16
Initial sequencing and analysis of the human genome

Eric S. Lander
Lauren M. Linton
Michael J. Morgan
articles01 Feb 2001
Nature

Volume: 409, P: 860-921
Active hydrothermal vents in the Woodlark Basin may act as dispersing centres for hydrothermal fauna

La Scala Vent Field, near the Solomon Islands in the Pacific Ocean, comprises diffuse vents and vigorous black smokers and hosts large beds of stalked barnacles and bacterial mats at vent peripheries, according to ship-borne multi-beam echo sounding and remotely operated vehicle surveys.

Cédric Boulart
Olivier Rouxel
Didier Jollivet
ResearchOpen Access17 Mar 2022
Communications Earth & Environment

Volume: 3, P: 1-16

Search

Off-target response to decoy oligodeoxynucleotide treatment

Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays

Genomic basis for RNA alterations in cancer

The co-occurrence of genetic variants in the TYR and OCA2 genes confers susceptibility to albinism

The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA

Emergence of methicillin resistance predates the clinical use of antibiotics

The landscape of viral associations in human cancers

Sense from sequence reads: methods for alignment and assembly

RNA modifications detection by comparative Nanopore direct RNA sequencing

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration

The contribution of common regulatory and protein-coding TYR variants to the genetic architecture of albinism

Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes

Comparative genomics: genome-wide analysis in metazoan eukaryotes

A universal programmable Gaussian boson sampler for drug discovery

The flotation of magmatic sulfides transfers Cu-Au from magmas to seafloor massive sulfide deposits

Initial sequencing and analysis of the human genome

Active hydrothermal vents in the Woodlark Basin may act as dispersing centres for hydrothermal fauna

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