Nature Search

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Aude Nicolas
Richard Sherva
Jean-Charles Lambert
ResearchOpen Access18 Jun 2025
Nature Genetics

P: 1-13
In vitro synergistic anti-prion effect of cholesterol ester modulators

Christina Doriana Orrù
Maria Dolores Cannas
Alessandra Pani
ResearchOpen Access21 Oct 2009
Nature Precedings

P: 1
Glucose-6-phosphate-dehydrogenase deficiency as a risk factor in proliferative disorder development

Antonella Mandas
Enrico Peiretti
Maurizio Fossarello
ResearchOpen Access30 Mar 2009
Nature Precedings

P: 1
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder

Cees J. Weeland
Selina Kasprzak
Chris Vriend
ResearchOpen Access21 Feb 2022
Translational Psychiatry

Volume: 12, P: 1-10
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm

Machine learning can be used to identify subtypes of psychiatric disease. Here the authors identified two neurostructural subgroups in schizophrenia, each showing reproducibility and generalizability across different collection locations and illness stages, using the SuStain algorithm.

Yuchao Jiang
Cheng Luo
Jianfeng Feng
ResearchOpen Access17 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

In this largest whole-exome sequencing study of epilepsies to date, the Epi25 Collaborative identified extremely rare variants that confer risk for diverse epilepsy subtypes, highlighting roles in synaptic transmission and neuronal excitability.

Siwei Chen
Bassel W. Abou-Khalil
Samuel F. Berkovic
Research03 Oct 2024
Nature Neuroscience

Volume: 27, P: 1864-1879
Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters

Willem B. Bruin
Luke Taylor
Guido A. van Wingen
ResearchOpen Access08 Oct 2020
Translational Psychiatry

Volume: 10, P: 1-12
Publisher Correction: Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment

Diego Scheggia
Rosa Mastrogiacomo
Francesco Papaleo
Amendments and CorrectionsOpen Access29 Aug 2018
Nature Communications

Volume: 9, P: 1
A worldwide study of white matter microstructural alterations in people living with Parkinson’s disease

Conor Owens-Walton
Talia M. Nir
Ysbrand van der Werf
ResearchOpen Access11 Aug 2024
npj Parkinson's Disease

Volume: 10, P: 1-12
Cortical morphology in patients with the deficit and non-deficit syndrome of schizophrenia: a worldwide meta- and mega-analyses

Nerisa Banaj
Daniela Vecchio
Federica Piras
ResearchOpen Access29 Aug 2023
Molecular Psychiatry

Volume: 28, P: 4363-4373
Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment

Patients with schizophrenia show varied response to antipsychotics. Here, the authors demonstrate in patients under antipsychotics treatment that a haplotype associated with lower dysbindin-1 expression correlated with better executive functions, providing further mechanistic support from mouse models.

Diego Scheggia
Rosa Mastrogiacomo
Francesco Papaleo
ResearchOpen Access11 Jun 2018
Nature Communications

Volume: 9, P: 1-11
White matter microstructure and its relation to clinical features of obsessive–compulsive disorder: findings from the ENIGMA OCD Working Group

Fabrizio Piras
Federica Piras
Gianfranco Spalletta
ResearchOpen Access17 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-11
White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim
Gakyung Kim
Jiook Cha
ResearchOpen Access07 Feb 2024
Molecular Psychiatry

Volume: 29, P: 1063-1074
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
Amendments and CorrectionsOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-2
The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Willem B. Bruin
Yoshinari Abe
Guido A. van Wingen
ResearchOpen Access02 May 2023
Molecular Psychiatry

Volume: 28, P: 4307-4319
In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis

Claudia Barth
Sinead Kelly
Ingrid Agartz
ResearchOpen Access12 Dec 2022
Molecular Psychiatry

Volume: 28, P: 1159-1169
A worldwide study of subcortical shape as a marker for clinical staging in Parkinson’s disease

Max A. Laansma
Yuji Zhao
Boris A. Gutman
ResearchOpen Access19 Nov 2024
npj Parkinson's Disease

Volume: 10, P: 1-13
The unbalanced reorganization of weaker functional connections induces the altered brain network topology in schizophrenia

Rossana Mastrandrea
Fabrizio Piras
Tommaso Gili
ResearchOpen Access28 Jul 2021
Scientific Reports

Volume: 11, P: 1-14
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Paul M. Thompson
Neda Jahanshad
Vladimir Zelman
ReviewsOpen Access20 Mar 2020
Translational Psychiatry

Volume: 10, P: 1-28
Antimicrobial sulfonamides clear latent Kaposi sarcoma herpesvirus infection and impair MDM2–p53 complex formation

Fabrizio Angius
Enrica Piras
Angela Ingianni
Research14 Jun 2017
The Journal of Antibiotics

Volume: 70, P: 962-966
Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures

Eamonn Kennedy
Shashank Vadlamani
Giovana B. Zunta-Soares
ResearchOpen Access16 Oct 2024
Scientific Reports

Volume: 14, P: 1-15
Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation

Maria Patrizia Mongiardi
Giulia Radice
Maria Laura Falchetti
Research09 Apr 2019
Oncogene

Volume: 38, P: 5413-5424
Correction: White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Bo-Gyeom Kim
Gakyung Kim
Jiook Cha
Amendments and CorrectionsOpen Access07 Mar 2024
Molecular Psychiatry

Volume: 29, P: 1216
Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study

Shuqing Si
Anbreen Bi
Matthew J. Kempton
ResearchOpen Access10 Jan 2024
Molecular Psychiatry

Volume: 29, P: 496-504
Correction: The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium

Willem B. Bruin
Yoshinari Abe
Guido A. van Wingen
Amendments and CorrectionsOpen Access15 Aug 2023
Molecular Psychiatry

Volume: 28, P: 4320
Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

Laura S. van Velzen
Maria R. Dauvermann
Lianne Schmaal
ResearchOpen Access07 Sept 2022
Molecular Psychiatry

Volume: 27, P: 4550-4560
Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

Constantinos Constantinides
Laura K. M. Han
Esther Walton
ResearchOpen Access09 Dec 2022
Molecular Psychiatry

Volume: 28, P: 1201-1209
Macro- and micro-structural cerebellar and cortical characteristics of cognitive empathy towards fictional characters in healthy individuals

Eleonora Picerni
Daniela Laricchiuta
Gianfranco Spalletta
ResearchOpen Access22 Apr 2021
Scientific Reports

Volume: 11, P: 1-12
Organization and hierarchy of the human functional brain network lead to a chain-like core

Rossana Mastrandrea
Andrea Gabrielli
Tommaso Gili
ResearchOpen Access07 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
High-density lipoprotein contribute to G0-G1/S transition in Swiss NIH/3T3 fibroblasts

Fabrizio Angius
Stefano Spolitu
Barbara Batetta
ResearchOpen Access07 Dec 2015
Scientific Reports

Volume: 5, P: 1-13
A large, curated, open-source stroke neuroimaging dataset to improve lesion segmentation algorithms

Sook-Lei Liew
Bethany P. Lo
Chunshui Yu
ResearchOpen Access16 Jun 2022
Scientific Data

Volume: 9, P: 1-12

Search

Filter By:

Search

Quick links