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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Genetic map of regional sulcal morphology in the human brain from UK biobank data

Genetic associations with particular patterns of brain folding may provide insight into brain development and function. Here, the authors identify and replicate 388 genetic associations with brain sulcal morphology across 40,169 UK Biobank MRI scans, revealing insights into the processes guiding cortical development and genetic correlations with neuropsychiatric phenotypes.

Benjamin B. Sun
Stephanie J. Loomis
Christopher D. Whelan
ResearchOpen Access14 Oct 2022
Nature Communications

Volume: 13, P: 1-13
The reliability and heritability of cortical folds and their genetic correlations across hemispheres

Fabrizio Pizzagalli et al. study the genetics factors that regulate cortical folding patterning in the brain. They use in vivo brain MRI datasets from around the world and report the reliability and heritability of sulcal morphometric characteristics for 61 sulci per hemisphere of the human brain. They uncover hemisphere-specific genetic influences on the cerebral cortex.

Fabrizio Pizzagalli
Guillaume Auzias
Neda Jahanshad
ResearchOpen Access15 Sept 2020
Communications Biology

Volume: 3, P: 1-12
Author Correction: The challenge of mapping the human connectome based on diffusion tractography

Klaus H. Maier-Hein
Peter F. Neher
Maxime Descoteaux
Amendments and CorrectionsOpen Access04 Nov 2019
Nature Communications

Volume: 10, P: 1-2
The challenge of mapping the human connectome based on diffusion tractography

Though tractography is widely used, it has not been systematically validated. Here, authors report results from 20 groups showing that many tractography algorithms produce both valid and invalid bundles.

Klaus H. Maier-Hein
Peter F. Neher
Maxime Descoteaux
ResearchOpen Access07 Nov 2017
Nature Communications

Volume: 8, P: 1-13
White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa

Reza Tadayonnejad
Fabrizio Pizzagalli
Jamie D. Feusner
ResearchOpen Access05 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Paul M. Thompson
Neda Jahanshad
Vladimir Zelman
ReviewsOpen Access20 Mar 2020
Translational Psychiatry

Volume: 10, P: 1-28

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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Genetic map of regional sulcal morphology in the human brain from UK biobank data

The reliability and heritability of cortical folds and their genetic correlations across hemispheres

Author Correction: The challenge of mapping the human connectome based on diffusion tractography

The challenge of mapping the human connectome based on diffusion tractography

White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

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