Nature Search

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

Raymond K. Walters
Renato Polimanti
Arpana Agrawal
Research26 Nov 2018
Nature Neuroscience

Volume: 21, P: 1656-1669
Genetic associations between orexin genes and phenotypes related to behavioral regulation in humans, including substance use

Fazil Aliev
David De Sa Nogueira
Danielle M. Dick
ResearchOpen Access29 Jan 2025
Molecular Psychiatry

Volume: 30, P: 2922-2930
Genetic diversity fuels gene discovery for tobacco and alcohol use

A multi-ancestry meta-regression study analyses diverse genome-wide association studies and genome loci associated with tobacco and alcohol use.

Gretchen R. B. Saunders
Xingyan Wang
Scott Vrieze
ResearchOpen Access07 Dec 2022
Nature

Volume: 612, P: 720-724
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits

There is strong genetic evidence for cigarette smoking behaviors, yet little is known on nicotine dependence (ND). Here, the authors perform a genome-wide association study on ND in 58,000 smokers, identifying five genome-wide significant loci.

Bryan C. Quach
Michael J. Bray
Dana B. Hancock
ResearchOpen Access03 Nov 2020
Nature Communications

Volume: 11, P: 1-13
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Richard Karlsson Linnér
Travis T. Mallard
Danielle M. Dick
Amendments and Corrections06 Dec 2024
Nature Neuroscience

Volume: 28, P: 213
Genome-wide association study identifies 48 common genetic variants associated with handedness

A genome-wide association study of 1.7 million individuals identified 41 genetic variants associated with left-handedness and 7 associated with ambidexterity. The genetic correlation between the traits was low, thereby implying different aetiologies.

Gabriel Cuellar-Partida
Joyce Y. Tung
Sarah E. Medland
Research28 Sept 2020
Nature Human Behaviour

Volume: 5, P: 59-70
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

This paper identified >500 genetic loci associated with behaviors and disorders related to self-regulation, including addiction and child behavior problems. The resulting genetic risk scores predict several behavioral, medical and social outcomes.

Richard Karlsson Linnér
Travis T. Mallard
Danielle M. Dick
Research26 Aug 2021
Nature Neuroscience

Volume: 24, P: 1367-1376
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Using a sample of more than 1 million individuals, Hatoum et al. identify genomic loci associated with general and substance-specific addiction risk.

Alexander S. Hatoum
Sarah M. C. Colbert
Arpana Agrawal
Research22 Mar 2023
Nature Mental Health

Volume: 1, P: 210-223
Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis

Jorim J. Tielbeek
Emil Uffelmann
Danielle Posthuma
Research25 Oct 2022
Molecular Psychiatry

Volume: 27, P: 4453-4463
Genetic nurture effects for alcohol use disorder

Nathaniel S. Thomas
Jessica E. Salvatore
Denise Scott
Research17 Oct 2022
Molecular Psychiatry

Volume: 28, P: 759-766
Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts

Peter B. Barr
Morgan N. Driver
Danielle M. Dick
Research04 Oct 2022
Molecular Psychiatry

Volume: 27, P: 4633-4641
Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples

Peter B. Barr
Albert Ksinan
Danielle M. Dick
ResearchOpen Access18 Jun 2020
Translational Psychiatry

Volume: 10, P: 1-9
Predicting alcohol use disorder remission: a longitudinal multimodal multi-featured machine learning approach

Sivan Kinreich
Vivia V. McCutcheon
Bernice Porjesz
ResearchOpen Access15 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-10
Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

Aline Jelenkovic
Reijo Sund
Karri Silventoinen
ResearchOpen Access14 May 2020
Scientific Reports

Volume: 10, P: 1-11
Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance

Jacquelyn L. Meyers
Jessica E. Salvatore
Arpana Agrawal
ResearchOpen Access21 Oct 2019
Translational Psychiatry

Volume: 9, P: 1-12
Glycogen synthase kinase 3 beta regulates ethanol consumption and is a risk factor for alcohol dependence

Andrew van der Vaart
Xianfang Meng
Michael F. Miles
Research06 Sept 2018
Neuropsychopharmacology

Volume: 43, P: 2521-2531
Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Aline Jelenkovic
Reijo Sund
Karri Silventoinen
ResearchOpen Access23 Jun 2016
Scientific Reports

Volume: 6, P: 1-13
A multivariate twin study of the genetic association between present moment attention and subjective wellbeing

Kirk Warren Brown
Fazil Aliev
Chelsea Sawyers
ResearchOpen Access14 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood

Kit K. Elam
Thao Ha
Kathryn Lemery-Chalfant
ResearchOpen Access17 Nov 2021
Scientific Reports

Volume: 11, P: 1-9
Genetic association study of childhood aggression across raters, instruments, and age

Hill F. Ip
Camiel M. van der Laan
Dorret I. Boomsma
ResearchOpen Access30 Jul 2021
Translational Psychiatry

Volume: 11, P: 1-9
Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk

Peter B. Barr
Travis T. Mallard
Danielle M. Dick
ResearchOpen Access30 Sept 2022
Translational Psychiatry

Volume: 12, P: 1-8
Investigating genetically stratified subgroups to better understand the etiology of alcohol misuse

Anaïs B. Thijssen
Karen Chartier
Jeanne E. Savage
ResearchOpen Access25 Jul 2023
Molecular Psychiatry

Volume: 28, P: 4225-4233

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