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Showing 1–5 of 5 results
Advanced filters: Author: Federico Comitani Clear advanced filters

  • Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with survival, in addition to the early emergence of metastatic clones.

    • Nathaniel D. Anderson
    • Yael Babichev
    • Adam Shlien
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • A new multilevel clustering approach applied retrospectively to 13,000 transcriptomes of different tumors reveals a new diagnostic classification of childhood cancers, in some cases allowing a better prediction of disease outcomes.

    • Federico Comitani
    • Joshua O. Nash
    • Adam Shlien
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 656-666

  • Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.

    • Matthew D. Young
    • Thomas J. Mitchell
    • Sam Behjati
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19