Nature Search

CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors

Chen at al. show that CHD1 loss in SPOP-mutated prostate tumors confers castration resistance by increasing SREBP2-mediated cholesterol synthesis and subsequent androgen supply, an effect counteracted by combined androgen and cholesterol inhibition.

Feiyu Chen
Haoyan Li
Di Zhao
Research13 May 2025
Nature Cancer

Volume: 6, P: 854-873
Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche

The histone methyltransferase ASH1L has been linked to tumorigenesis, mainly in leukemia. Here, authors report that ASH1L cooperates with HIF-1α to induce a pro-metastatic transcriptome in prostate cancer cells, and promotes conversion of monocytes to lipid-associated tumor-associated macrophages in the bone metastatic niche.

Chenling Meng
Kevin Lin
Di Zhao
ResearchOpen Access20 May 2025
Nature Communications

Volume: 16, P: 1-23
Nickel-catalysed deuteration of benzylic C(sp³)–H bonds using D₂O

A heterogeneous nickel-catalysed deuteration reaction of benzylic C(sp³)–H bonds in alkylarenes and methylarenes using D₂O is developed. Such metal–H₂–D₂O systems could be extended to other catalytic reactions for the preparation of deuterium-labelled compounds in the future.

Feiyu Qiu
Lingyun Yang
Wu Li
Research22 May 2025
Nature Synthesis

P: 1-10
Main-group element-boosted oxygen electrocatalysis of Cu-N-C sites for zinc-air battery with cycling over 5000 h

Balancing the activity and stability of oxygen electrocatalysts is challenging but crucial for rechargeable zinc-air batteries. Here, the authors report a highly active Cu-N-C catalyst boosted by the main-group element for zinc-air battery with a long cycle stability over 5000 h.

Yifan Li
Aijian Huang
Ruitao Lv
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-13
Homogeneous polymer-ionic solvate electrolyte with weak dipole-dipole interaction enabling long cycling pouch lithium metal battery

Solid polymer electrolytes suffer from limited ionic conductivity and poor interfacial stability for lithium batteries. Here, authors propose a fluorinated ether diluent to reduce the dipole-dipole interaction of ionic solvate with the polymer matrix and induce the formation of aggregates.

Likun Chen
Tian Gu
Feiyu Kang
ResearchOpen Access14 Apr 2025
Nature Communications

Volume: 16, P: 1-12
A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy

LYTAC strategies often face challenges in solid tumor penetration and synthesis. Here, the authors introduce Pep-TACs, a modular TFRC-based covalent peptide degradation platform that effectively degrades membrane protein PD-L1. This approach significantly suppresses both anti-PD-1-responsive and -resistant tumor growth, particularly in brain tumors.

Youmei Xiao
Zhuoying He
Yanfeng Gao
ResearchOpen Access06 Feb 2025
Nature Communications

Volume: 16, P: 1-16
Amorphous organic-hybrid vanadium oxide for near-barrier-free ultrafast-charging aqueous zinc-ion battery

Promoting solid ion-diffusion is essential for fast-charging battery. Here, authors present near-barrier-free ion dynamics in an amorphous organic-hybrid vanadium oxide-based zinc ion battery and developed Ah-level fast-charging pouch cell.

Mingzhuang Liu
Xinghua Li
Yichun Liu
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-13
A strategy for Cas13 miniaturization based on the structure and AlphaFold

Small Cas enzymes are required for therapeutic use. Here the authors report an Interaction, Dynamics and Conservation (IDC) strategy for protein miniaturisation and use this to generate five compact variants of Cas13 based on a combination of IDC strategy and AlphaFold2.

Feiyu Zhao
Tao Zhang
Zhanjun Li
ResearchOpen Access08 Sept 2023
Nature Communications

Volume: 14, P: 1-13
Lithium hexamethyldisilazide as electrolyte additive for efficient cycling of high-voltage non-aqueous lithium metal batteries

High-voltage non-aqueous lithium metal batteries suffer from poor cycling stability due to the presence of impurities in the electrolyte solution. Here, the authors report lithium hexamethyldisilazide to scavenge HF and H₂O, prevent the Ni dissolution and suppress side reactions during cycling.

Danfeng Zhang
Ming Liu
Yan-Bing He
ResearchOpen Access15 Nov 2022
Nature Communications

Volume: 13, P: 1-11
fNIRS experimental study on the impact of AI-synthesized familiar voices on brain neural responses

Weijia Zhang
Jiaju Li
Shaomin Cai
ResearchOpen Access15 May 2025
Scientific Reports

Volume: 15, P: 1-16
UFL1 triggers replication fork degradation by MRE11 in BRCA1/2-deficient cells

The mechanisms of stalled fork degradation in BRCA1/2-deficient cells remain unclear. UFL1, an UFM1-specific E3 ligase, was found to catalyze PTIP UFMylation at lysine 148, promoting stalled fork degradation by the MRE11 nuclease.

Tian Tian
Junliang Chen
Ting Liu
Research22 Apr 2024
Nature Chemical Biology

Volume: 20, P: 1650-1661
Unveiling the spatial and temporal variation of customer sentiment in hotel experiences: a case study of Beppu City, Japan

Feiyu Hu
Jun Pan
Haijun Wang
ResearchOpen Access19 Dec 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-12
Self-regulated underwater phototaxis of a photoresponsive hydrogel-based phototactic vehicle

An untethered phototactic soft machine composed of poly(N-isopropylacrylamide) hydrogel blended with graphene oxide and gold nanoparticles demonstrates underwater full-space artificial phototaxis and manoeuvres around obstacles in natural sunlight.

Guodong Hou
Xu Zhang
Xiaoshi Qian
Research21 Aug 2023
Nature Nanotechnology

Volume: 19, P: 77-84
A dielectric electrolyte composite with high lithium-ion conductivity for high-voltage solid-state lithium metal batteries

The authors developed a highly conductive and dielectric composite solid-state electrolyte by coupling BaTiO₃ and Li_0.33La_0.56TiO_3–x nanowires with a side-by-side heterojunction structure in a polyvinylidene difluoride matrix, which simultaneously promotes the dissociation of lithium salts to produce more movable Li ions and efficiently transports the generated movable Li ions.

Peiran Shi
Jiabin Ma
Feiyu Kang
Research09 Mar 2023
Nature Nanotechnology

Volume: 18, P: 602-610
Genome remodelling in a basal-like breast cancer metastasis and xenograft

Massively parallel DNA sequencing allows entire genomes to be screened for genetic changes associated with tumour progression. Here, the genomes of four DNA samples from a 44-year-old African-American patient with basal-like breast cancer were analysed. The samples came from peripheral blood, the primary tumour, a brain metastasis and a xenograft derived from the primary tumour. The findings indicate that cells with a distinct subset of the primary tumour mutation might be selected during metastasis and xenografting.

Li Ding
Matthew J. Ellis
Elaine R. Mardis
Research15 Apr 2010
Nature

Volume: 464, P: 999-1005
Caging tin oxide in three-dimensional graphene networks for superior volumetric lithium storage

The excessive porous space in carbon anodes for lithium-ion batteries has to be utilized for high volumetric performance. Here the authors show an adaptable sulfur template strategy to yield graphene-caged noncarbon materials with a precisely controlled amount of void, enabling ultrahigh volumetric lithium storage.

Junwei Han
Debin Kong
Quan-Hong Yang
ResearchOpen Access26 Jan 2018
Nature Communications

Volume: 9, P: 1-9
Cross-linked beta alumina nanowires with compact gel polymer electrolyte coating for ultra-stable sodium metal battery

Here the authors show a beta alumina nanowires/gel polymer composite electrolyte design. The dense and homogeneous solid-liquid hybrid sodium-ion transportation channels promote uniform sodium deposition and stripping and significantly improve the performance of a Na metal battery.

Danni Lei
Yan-Bing He
Feiyu Kang
ResearchOpen Access18 Sept 2019
Nature Communications

Volume: 10, P: 1-11
Whole-genome analysis informs breast cancer response to aromatase inhibition

Whole-genome analysis of oestrogen-receptor-positive tumours in patients treated with aromatase inhibitors show that distinct phenotypes are associated with specific patterns of somatic mutations; however, most recurrent mutations are relatively infrequent so prospective clinical trials will require comprehensive sequencing and large study populations.

Matthew J. Ellis
Li Ding
Elaine R. Mardis
ResearchOpen Access10 Jun 2012
Nature

Volume: 486, P: 353-360
Secondary batteries with multivalent ions for energy storage

Chengjun Xu
Yanyi Chen
Dangsheng Su
ResearchOpen Access14 Sept 2015
Scientific Reports

Volume: 5, P: 1-8
Flexible asymmetric supercapacitors based on ultrathin two-dimensional nanosheets with outstanding electrochemical performance and aesthetic property

Shan Shi
Chengjun Xu
Feiyu Kang
ResearchOpen Access06 Sept 2013
Scientific Reports

Volume: 3, P: 1-8
Machine learning discrimination of Gleason scores below GG3 and above GG4 for HSPC patients diagnosis

Bingyu Zhu
Longguo Dai
Yu Bai
ResearchOpen Access27 Oct 2024
Scientific Reports

Volume: 14, P: 1-19
Association between 5-item modified frailty index and clinical outcomes in elderly rectal cancer patients after radical surgery

Hong Wu
Feiyu Shi
Junjun She
ResearchOpen Access04 Feb 2025
Scientific Reports

Volume: 15, P: 1-13
Investigation of spinopelvic sagittal alignment and its correlations in asymptomatic pediatric populations

Hao Qi
ZengHui Zhao
Di Zhang
ResearchOpen Access26 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
One thousand plant transcriptomes and the phylogenomics of green plants

The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

James H. Leebens-Mack
Michael S. Barker
Gane Ka-Shu Wong
ResearchOpen Access23 Oct 2019
Nature

Volume: 574, P: 679-685
An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk, local immunosuppression and tumor progression

Liang Wu
Jiayan Yan
Jian Zhou
ResearchOpen Access19 Jun 2023
Cell Research

Volume: 33, P: 585-603
ADAMDEC1 promotes the malignant progression of cholangiocarcinoma by regulating NF-κB signaling pathway

Shuo Zhou
Yuhang Yang
Yongliang Chen
ResearchOpen Access04 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
Recycling of sodium-ion batteries

Sodium-ion batteries (SIBs), an emerging type of sustainable battery, still need to be recycled for environmental and economic reasons. Strategies to recycle spent SIBs should be made during the initial stages of commercialization to ensure that SIBs are designed for ease of recycling, efficiency and low operation costs. This Perspective article summarizes the material components of SIBs, discusses strategies for their recycling and outlines the associated challenges and future outlook of SIB recycling.

Yun Zhao
Yuqiong Kang
Baohua Li
Reviews19 Jul 2023
Nature Reviews Materials

Volume: 8, P: 623-634
Enhancing low-dose radiotherapy efficacy with PARP inhibitors via FBL-mediated oxidative stress response in colorectal cancer

Ming Wen
Yanfang Qiu
Rong Tan
ResearchOpen Access08 Nov 2024
Oncogene

Volume: 44, P: 228-240
What influences user continuous intention of digital museum: integrating task-technology fit (TTF) and unified theory of acceptance and usage of technology (UTAUT) models

Feiyu Zheng
Shan Wu
Yiqun Bai
ResearchOpen Access24 Jul 2024
Heritage Science

Volume: 12, P: 1-19
Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding

Jikai Deng
Shimin Yang
Yu Chen
ResearchOpen Access29 May 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-16
Altered gut microbiome composition by appendectomy contributes to colorectal cancer

Feiyu Shi
Gaixia Liu
Junjun She
ResearchOpen Access20 Dec 2022
Oncogene

Volume: 42, P: 530-540
FAM201A encodes small protein NBASP to inhibit neuroblastoma progression via inactivating MAPK pathway mediated by FABP5

The long non-coding RNA FAM201A encodes a short peptide NBASP that suppresses neuroblastoma carcinogenesis by down-regulating FABP5 to inactivate the MAPK pathway.

Mujie Ye
Runnan Gao
Kuiran Dong
ResearchOpen Access12 Jul 2023
Communications Biology

Volume: 6, P: 1-12
Combined MediaPipe and YOLOv5 range of motion assessment system for spinal diseases and frozen shoulder

Weijia Zhang
Yulin Li
Feiyu Chen
ResearchOpen Access10 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
In-situ growth of MnO₂ crystals under nanopore-constraint in carbon nanofibers and their electrochemical performance

TrungHieu Le
Ying Yang
Feiyu Kang
ResearchOpen Access21 Nov 2016
Scientific Reports

Volume: 6, P: 1-11
Rice husk ash addition to acid red soil improves the soil property and cotton seedling growth

Mengyao Yin
Xuan Li
Feiyu Tang
ResearchOpen Access01 Feb 2022
Scientific Reports

Volume: 12, P: 1-9
High-performance sodium-ion hybrid capacitors based on an interlayer-expanded MoS₂/rGO composite: surpassing the performance of lithium-ion capacitors in a uniform system

Sodium ion hybrid capacitors is fabricated by interlayer-expanded MoS₂/rGO composite and it shows greater performance than lithium ion capacitor.

Changzhen Zhan
Wei Liu
Zheng-Hong Huang
ResearchOpen Access20 Aug 2018
NPG Asia Materials

Volume: 10, P: 775-787
Correction: Corrigendum: Flexible asymmetric supercapacitors based on ultrathin two-dimensional nanosheets with outstanding electrochemical performance and aesthetic property

Shan Shi
Chengjun Xu
Feiyu Kang
Amendments and Corrections11 Feb 2014
Scientific Reports

Volume: 4, P: 1
Gassing in Li₄Ti₅O₁₂-based batteries and its remedy

Yan-Bing He
Baohua Li
Feiyu Kang
ResearchOpen Access03 Dec 2012
Scientific Reports

Volume: 2, P: 1-9
PIWIL1 governs the crosstalk of cancer cell metabolism and immunosuppressive microenvironment in hepatocellular carcinoma

Ning Wang
Hor-Yue Tan
Yibin Feng
ResearchOpen Access26 Feb 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-13

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