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Showing 1–4 of 4 results
Advanced filters: Author: Felipe Beckedorff Clear advanced filters

  • AML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO with chromatin, and consequently, promotes leukemic self-renewal.

    • Ye Xu
    • Na Man
    • Stephen Nimer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Palmitic acid induces stable transcriptional and chromatin changes that lead to long-term stimulation of metastasis in orthotopic models of cancer through the secretion by tumour-associated Schwann cells of a specialized proregenerative extracellular matrix, the ablation of which inhibits metastasis initiation.

    • Gloria Pascual
    • Diana Domínguez
    • Salvador Aznar Benitah
    Research
    Nature
    Volume: 599, P: 485-490

  • The role of Polycomb Repressive Complex 1 (PRC1) is well described in development. Here, the authors investigate canonical PRC1’s regulation of transcriptional programs in breast cancer where, in addition to its repressive function, it is also recruited to oncogenic active enhancers to regulate enhancer activity and chromatin accessibility.

    • Ho Lam Chan
    • Felipe Beckedorff
    • Lluis Morey
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16