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GSK3 signalling in neural development

Glycogen synthase kinase 3 (GSK3) proteins and their upstream and downstream regulators have key roles in neurodevelopmental processes. Hur and Zhou review the mechanisms that regulate GSK3 activity and discuss how GSK3 controls neurogenesis, neuronal polarization and axon growth.

Eun-Mi Hur
Feng-Quan Zhou
Reviews01 Aug 2010
Nature Reviews Neuroscience

Volume: 11, P: 539-551
Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

How the neighboring cells contribute to the survival and functions of neuronal cells remains elusive. Here, authors identified the cell-cell interactions between retinal ganglion cells (RGCs) and other cells after RGC injury and discovered the μ-opioid receptor promotes RGC resilience.

Cheng Qian
Ying Xin
Jiang Qian
ResearchOpen Access11 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Genetic dissection of axon regeneration via in vivo electroporation of adult mouse sensory neurons

Dorsal root ganglion neurons can regenerate after injury, but the mechanisms underlying axon regrowth are unclear. To address this, an electroporation transfection method is developed that can alter the gene expression of dorsal root ganglion cells in a living adult mouse, providing a tool to study axon regeneration.

Saijilafu
Eun-Mi Hur
Feng-Quan Zhou
Research22 Nov 2011
Nature Communications

Volume: 2, P: 1-10
PI3K–GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1

Nerve damage in the peripheral nervous system induces spontaneous axon regeneration. Saijilafu et al.show that this regeneration requires phosphatidylinositol 3-kinase signalling, which activates glycogen synthase kinase 3 and the transcription factor Smad1, and not mammalian target of rapamycin or ß-catenin.

Saijilafu
Eun-Mi Hur
Feng-Quan Zhou
Research28 Oct 2013
Nature Communications

Volume: 4, P: 1-14
AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons

A gradient of cAMP in developing hippocampal neurons that is important for axon elongation is shaped by spatial differences in phosphodiesterase localization and is maintained by AKAP-anchored PKA, as revealed by using FRET-based biosensors.

Kirill Gorshkov
Sohum Mehta
Jin Zhang
Research13 Feb 2017
Nature Chemical Biology

Volume: 13, P: 425-431
Programmed cell senescence in skeleton during late puberty

Mesenchymal stem cells are essential for bone development, but it is unclear if their activity is maintained after late puberty, when bone growth decelerates. The authors show that during late puberty in mice, these cells undergo senescence under the epigenetic control of Ezh2.

Changjun Li
Yu Chai
Mei Wan
ResearchOpen Access03 Nov 2017
Nature Communications

Volume: 8, P: 1-15
Acquisition frame rate affects microtubule plus-end tracking analysis

Philip R Nicovich
Feng-Quan Zhou
Correspondence27 Feb 2014
Nature Methods

Volume: 11, P: 219-220
UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury

Lu Ding
Weiwei Chu
David Y. B. Deng
ResearchOpen Access28 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-17

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GSK3 signalling in neural development

Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

Genetic dissection of axon regeneration via in vivo electroporation of adult mouse sensory neurons

PI3K–GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1

AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons

Programmed cell senescence in skeleton during late puberty

Acquisition frame rate affects microtubule plus-end tracking analysis

UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury

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