Nature Search

Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression

The authors show that knocking out SMAD4, human NK cells resist TGFβ and activin A suppression and demonstrate that SMAD4 knockout enhances the antitumor function of several NK cell products in clinical development.

Anna Rea
Sara Santana-Hernández
Aura Muntasell
ResearchOpen Access21 Mar 2025
Nature Immunology

Volume: 26, P: 582-594
Prediction of long-term recurrence-free and overall survival in early-onset colorectal cancer: the ENCORE multi-centre study

Alessandro Mannucci
Goretti Hernández
Ajay Goel
ResearchOpen Access21 Jun 2025
npj Precision Oncology

Volume: 9, P: 1-11
Environmental effects on surface lead–calcium apatite formation on Roman wall paintings

Francesc Albert-Tortosa
Núria Jiménez
Nati Salvadó
ResearchOpen Access27 May 2025
Scientific Reports

Volume: 15, P: 1-13
Serrated polyposis—should we screen first-degree relatives?

Serrated polyposis syndrome (SPS) is a condition characterized by multiple and/or proximal serrated polyps in the colorectum. Several features of SPS suggest there is an underlying genetic disorder that is yet to be identified. A new study provides insights on the diagnostic yield of screening colonoscopy in first-degree relatives of patients with SPS.

Francesc Balaguer
Maria Pellise
News & Views22 Apr 2014
Nature Reviews Gastroenterology & Hepatology

Volume: 11, P: 333-334
Germline structural variant as the cause of Lynch Syndrome in a family from Ecuador

Gemma Llargués-Sistac
Laia Bonjoch
Sergi Castellví-Bel
ResearchOpen Access17 Jan 2025
npj Genomic Medicine

Volume: 10, P: 1-6
The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Analysis of 2,170 SARS-CoV-2 sequences from the first wave of the COVID-19 epidemic in Spain provides insights into transmission patterns and the effects of lockdown on the emergence of new variants.

Mariana G. López
Álvaro Chiner-Oms
Iñaki Comas
Research30 Sept 2021
Nature Genetics

Volume: 53, P: 1405-1414
Novel MLH1 duplication identified in Colombian families with Lynch syndrome

Virginia Alonso-Espinaco
María Dolores Giráldez
Sergi Castellví-Bel
Research12 Jan 2011
Genetics in Medicine

Volume: 13, P: 155-160
The Fanconi anemia DNA damage repair pathway in the spotlight for germline predisposition to colorectal cancer

Clara Esteban-Jurado
Sebastià Franch-Expósito
Sergi Castellví-Bel
ResearchOpen Access11 May 2016
European Journal of Human Genetics

Volume: 24, P: 1501-1505
Epigenetics of colorectal cancer: biomarker and therapeutic potential

Epigenetic modifications and regulators, including DNA methylation, histone modifications and non-coding RNA species, have key pathophysiological roles in colorectal cancer (CRC). This Review outlines these epigenetic aberrations in CRC and their potential as diagnostic, prognostic and predictive biomarkers and therapeutic targets.

Gerhard Jung
Eva Hernández-Illán
Ajay Goel
Reviews03 Jan 2020
Nature Reviews Gastroenterology & Hepatology

Volume: 17, P: 111-130
Quantification of rare somatic single nucleotide variants by droplet digital PCR using SuperSelective primers

Verónica Pablo-Fontecha
Eva Hernández-Illán
Jordi Camps
ResearchOpen Access03 Nov 2023
Scientific Reports

Volume: 13, P: 1-11
Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Mev Dominguez-Valentin
Julian R. Sampson
Pål Møller
ResearchOpen Access24 Jul 2019
Genetics in Medicine

Volume: 22, P: 15-25
Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Mev Dominguez-Valentin
Julian R. Sampson
Pål Møller
Amendments and CorrectionsOpen Access20 Jul 2020
Genetics in Medicine

Volume: 22, P: 1569
Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer

Clara Esteban-Jurado
Maria Vila-Casadesús
Sergi Castellví-Bel
ResearchOpen Access24 Jul 2014
Genetics in Medicine

Volume: 17, P: 131-142

Search

Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression

Prediction of long-term recurrence-free and overall survival in early-onset colorectal cancer: the ENCORE multi-centre study

Environmental effects on surface lead–calcium apatite formation on Roman wall paintings

Serrated polyposis—should we screen first-degree relatives?

Germline structural variant as the cause of Lynch Syndrome in a family from Ecuador

The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Novel MLH1 duplication identified in Colombian families with Lynch syndrome

The Fanconi anemia DNA damage repair pathway in the spotlight for germline predisposition to colorectal cancer

Epigenetics of colorectal cancer: biomarker and therapeutic potential

Quantification of rare somatic single nucleotide variants by droplet digital PCR using SuperSelective primers

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer

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