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Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice

Scheggia et al. show that a specific subpopulation of cortical neurons expressing somatostatin in the prefrontal cortex has a primary role in orchestrating the ability of mice to discriminate positive and negative affective states in others.

Diego Scheggia
Francesca Managò
Francesco Papaleo
Research16 Dec 2019
Nature Neuroscience

Volume: 23, P: 47-60
Cortico-cortical transfer of socially derived information gates emotion recognition

The circuit mechanisms underlying emotion recognition are unclear. Here, Dautan et al. show a role for a long-range feedback loop comprising somatostatin inhibitory projections from the medial prefrontal cortex (mPFC) to the retrosplenial cortex (RSC) and excitatory feedback projections from the RSC to the mPFC.

Daniel Dautan
Anna Monai
Francesco Papaleo
Research20 May 2024
Nature Neuroscience

Volume: 27, P: 1318-1332
Author Correction: Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons

Linda Maria Requie
Marta Gómez-Gonzalo
Giorgio Carmignoto
Amendments and Corrections25 Apr 2023
Nature Neuroscience

Volume: 26, P: 1129
Self-experience of a negative event alters responses to others in similar states through prefrontal cortex CRF mechanisms

Maltese et al. show in mice that experiencing an adverse event affects future interaction with others experiencing the same stressor. These self-experience socioemotional reactions are orchestrated by the corticotropin-releasing factor system in the medial prefrontal cortex.

Federica Maltese
Giada Pacinelli
Francesco Papaleo
Research03 Dec 2024
Nature Neuroscience

Volume: 28, P: 122-136
Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

The enzyme nicotinate phosphoribosyltransferase (NAPRT) mediates the rate-limiting step in NAD salvage pathway starting from nicotinic acid. Here the authors show that NAPRT can be detected extracellularly, binds to Toll like receptor 4, and activates NF-kB signaling and cytokine production in macrophage via NAD synthesis-independent pathways.

Antonella Managò
Valentina Audrito
Silvia Deaglio
ResearchOpen Access11 Sept 2019
Nature Communications

Volume: 10, P: 1-14
Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons

This study shows that burst-firing-induced astrocyte signaling potentiates glutamatergic transmission onto dopamine neurons in mouse VTA.

Linda Maria Requie
Marta Gómez-Gonzalo
Giorgio Carmignoto
Research17 Nov 2022
Nature Neuroscience

Volume: 25, P: 1639-1650
Publisher Correction: Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment

Diego Scheggia
Rosa Mastrogiacomo
Francesco Papaleo
Amendments and CorrectionsOpen Access29 Aug 2018
Nature Communications

Volume: 9, P: 1
Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia

Rosa Mastrogiacomo
Gabriella Trigilio
Francesco Papaleo
Research11 Jul 2022
Molecular Psychiatry

Volume: 27, P: 4201-4217
Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment

Patients with schizophrenia show varied response to antipsychotics. Here, the authors demonstrate in patients under antipsychotics treatment that a haplotype associated with lower dysbindin-1 expression correlated with better executive functions, providing further mechanistic support from mouse models.

Diego Scheggia
Rosa Mastrogiacomo
Francesco Papaleo
ResearchOpen Access11 Jun 2018
Nature Communications

Volume: 9, P: 1-11
Retinal biomarkers and pharmacological targets for Hermansky-Pudlak syndrome 7

Giovanni Luca Romano
Chiara Bianca Maria Platania
Claudio Bucolo
ResearchOpen Access04 Mar 2020
Scientific Reports

Volume: 10, P: 1-12
The role of GRK6 in animal models of Parkinson's Disease and L-DOPA treatment

Francesca Managò
Stefano Espinoza
Raul R. Gainetdinov
ResearchOpen Access05 Mar 2012
Scientific Reports

Volume: 2, P: 1-10
Metabotropic Glutamate Receptors 5 Blockade Reverses Spatial Memory Deficits in a Mouse Model of Parkinson's Disease

Elvira De Leonibus
Francesca Managò
Andrea Mele
Research13 Aug 2008
Neuropsychopharmacology

Volume: 34, P: 729-738
Chronic and Acute Intranasal Oxytocin Produce Divergent Social Effects in Mice

Huiping Huang
Caterina Michetti
Francesco Papaleo
Research04 Nov 2013
Neuropsychopharmacology

Volume: 39, P: 1102-1114

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