Nature Search

Genetic immune escape landscape in primary and metastatic cancer

A pan-cancer analysis of primary and metastatic tumors highlights the diversity of genetic immune escape mechanisms established during tumor evolution. The authors also present LILAC, a tool to characterize the HLA-I locus from whole-genome sequencing data.

Francisco Martínez-Jiménez
Peter Priestley
Edwin Cuppen
ResearchOpen Access10 May 2023
Nature Genetics

Volume: 55, P: 820-831
In silico saturation mutagenesis of cancer genes

A new computational approach to in silico mutagenesis screening allow comprehensive mapping of cancer driver mutations.

Ferran Muiños
Francisco Martínez-Jiménez
Nuria Lopez-Bigas
Research28 Jul 2021
Nature

Volume: 596, P: 428-432
Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer

Martínez-Jiménez et al. report how disruption of the ubiquitin–proteasome system affects cancer, estimating that >10% of driver mutations involve alterations in genes relevant in ubiquitin-mediated proteolysis, including E3 ligases and their targets.

Francisco Martínez-Jiménez
Ferran Muiños
Abel Gonzalez-Perez
Research02 Dec 2019
Nature Cancer

Volume: 1, P: 122-135
Five latent factors underlie response to immunotherapy

Analysis of human tumor datasets shows that all features that appear significantly associated with immunotherapy response and survival may be collapsed into five latent factors: tumor mutation burden, T cell effective infiltration, TGF-β activity in the microenvironment, prior treatment and tumor proliferative potential.

Joseph Usset
Axel Rosendahl Huber
Nuria Lopez-Bigas
ResearchOpen Access12 Sept 2024
Nature Genetics

Volume: 56, P: 2112-2120
Genomic and evolutionary classification of lung cancer in never smokers

Whole-genome sequencing of lung cancer in never smokers identifies different copy number subtypes and shows a lack of tobacco smoking signatures, even in cases exposed to secondhand smoke.

Tongwu Zhang
Philippe Joubert
Maria Teresa Landi
Research06 Sept 2021
Nature Genetics

Volume: 53, P: 1348-1359
Pan-cancer whole-genome comparison of primary and metastatic solid tumours

The genomic differences between primary and metastatic tumours are assessed across 23 cancer types using pan-cancer whole-genome analysis.

Francisco Martínez-Jiménez
Ali Movasati
Arne Van Hoeck
ResearchOpen Access10 May 2023
Nature

Volume: 618, P: 333-341
Rational design of non-resistant targeted cancer therapies

Francisco Martínez-Jiménez
John P. Overington
Marc A. Marti-Renom
ResearchOpen Access24 Apr 2017
Scientific Reports

Volume: 7, P: 1-18
Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

Genetic and Structural analysis of COVID patients cohort reveals a correlation between mitochondrial haplogroup and SARS-CoV-2 severity.

José Luis Cabrera-Alarcon
Raquel Cruz
José Antonio Enriquez
ResearchOpen Access09 Jan 2025
Communications Biology

Volume: 8, P: 1-12
Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium

Laura Marcos-Villar
Beatriz Perdiguero
Carmen Elena Gómez
ResearchOpen Access06 Mar 2024
npj Vaccines

Volume: 9, P: 1-15
A compendium of mutational cancer driver genes

This Review provides a brief historical perspective of our understanding of the role of cancer genes before presenting the Integrative OncoGenomics (IntOGen) platform, a bioinformatics method of mutational driver identification, which is beginning to reveal the compendium of driver genes across many tumour types as well as alluding to their tumorigenic mechanisms.

Francisco Martínez-Jiménez
Ferran Muiños
Nuria Lopez-Bigas
Reviews10 Aug 2020
Nature Reviews Cancer

Volume: 20, P: 555-572
Author Correction: Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium

Laura Marcos-Villar
Beatriz Perdiguero
Carmen Elena Gómez
Amendments and CorrectionsOpen Access18 May 2024
npj Vaccines

Volume: 9, P: 1

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