A study reveals that overexpression of a single target of neurogenin 2, Rnd2, can restore the neuronal migration defects of neurogenin 2-depleted neurons. Rnd2 is thus an atypical member of the Rho family of small GTP-ases, which regulate actin cytoskeleton dynamics, with its activity regulated at the gene transcription level, rather than by the usual post-translational GTP/GDP cycle.
- Julian Ik-Tsen Heng
- Laurent Nguyen
- François Guillemot
