Nature Search

Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice

Brain vascular impairment may occur early in diseases such as Alzheimer’s disease. Here the authors longitudinally study brain vascular dynamics in mice using advanced optical coherence tomography and deep learning algorithms, which enables tracking of slow vascular decline in aging and models of disease.

Konrad W. Walek
Sabina Stefan
Jonghwan Lee
ResearchOpen Access24 May 2023
Nature Communications

Volume: 14, P: 1-13
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Jean-Pierre Hugot
Mathias Chamaillard
Gilles Thomas
Research31 May 2001
Nature

Volume: 411, P: 599-603
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

The use of PET for detection of Aβ in the brain in AD has limitations; studies also indicate that retinal changes, including Aβ deposition, occur in AD. Here the authors demonstrate the potential to use in vivo retinal hyperspectral imaging as a surrogate for brain accumulation of Aβ.

Xavier Hadoux
Flora Hui
Peter van Wijngaarden
ResearchOpen Access17 Sept 2019
Nature Communications

Volume: 10, P: 1-12
Cerebral tissue pO₂ response to treadmill exercise in awake mice

Mohammad Moeini
Christophe Cloutier-Tremblay
Frédéric Lesage
ResearchOpen Access07 Aug 2020
Scientific Reports

Volume: 10, P: 1-11
Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue

Capillaries are thought to be the main suppliers of oxygen to tissues. Here the authors challenge this view by showing that, at baseline brain activity, half of blood oxygen is extracted from arterioles, whereas capillaries supply an oxygen reserve when neuronal activity is high or cerebral blood flow is decreased.

Sava Sakadžić
Emiri T. Mandeville
David A. Boas
Research08 Dec 2014
Nature Communications

Volume: 5, P: 1-11
Clustering of Crohn's disease within affected sibships

Jean-Pierre Hugot
Jean-Pierre Cézard
J Belaiche
Research14 Feb 2003
European Journal of Human Genetics

Volume: 11, P: 179-184
Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

The vascular, cellular and molecular changes underlying sex differences in mood disorders are unclear. Here, the authors show that blood-brain barrier dysfunction modulates anxiety- and depressive-like behaviors in female mice and endothelium-specific changes associated with maladaptive responses compared to resilience to stress.

Laurence Dion-Albert
Alice Cadoret
Caroline Menard
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-18
Alteration of functional connectivity despite preserved cerebral oxygenation during acute hypoxia

Marleen E. Bakker
Ismaël Djerourou
Matthieu P. Vanni
ResearchOpen Access15 Aug 2023
Scientific Reports

Volume: 13, P: 1-16
Compromised microvascular oxygen delivery increases brain tissue vulnerability with age

Mohammad Moeini
Xuecong Lu
Frédéric Lesage
ResearchOpen Access29 May 2018
Scientific Reports

Volume: 8, P: 1-17
Evaluation of stenoses using AI video models applied to coronary angiography

Élodie Labrecque Langlais
Denis Corbin
Robert Avram
ResearchOpen Access23 May 2024
npj Digital Medicine

Volume: 7, P: 1-13
The pulsatile brain, pulse pressure, cognition, and antihypertensive treatments in older adults: a functional NIRS study

Hanieh Mohammadi
Florent Besnier
Louis Bherer
Research30 Jan 2025
Journal of Human Hypertension

Volume: 39, P: 217-225
Genetic refinement and physical mapping of a chromosome 16q candidate region for inflammatory bowel disease

Habib Zouali
Mathias Chamaillard
Jean-Pierre Hugot
Research19 Oct 2001
European Journal of Human Genetics

Volume: 9, P: 731-742
High hydrostatic pressure is similar to Holder pasteurization in preserving donor milk antimicrobial activity

Léa Chantal Tran
Lucie Marousez
Marie Titécat
Research27 Jan 2024
Pediatric Research

Volume: 95, P: 1749-1753
A simulation study investigating potential diffusion-based MRI signatures of microstrokes

Rafat Damseh
Yuankang Lu
Frederic Lesage
ResearchOpen Access09 Jul 2021
Scientific Reports

Volume: 11, P: 1-15
Validation of red blood cell flux and velocity estimations based on optical coherence tomography intensity fluctuations

Paul J. Marchand
Xuecong Lu
Frédéric Lesage
ResearchOpen Access11 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
In Vivo Near-Infrared Fluorescence Imaging of Atherosclerosis Using Local Delivery of Novel Targeted Molecular Probes

Marie-Jeanne Bertrand
Maxime Abran
Jean-Claude Tardif
ResearchOpen Access25 Feb 2019
Scientific Reports

Volume: 9, P: 1-12
Machine-learning for the prediction of one-year seizure recurrence based on routine electroencephalography

Émile Lemoine
Denahin Toffa
Elie Bou Assi
ResearchOpen Access04 Aug 2023
Scientific Reports

Volume: 13, P: 1-13
Angiopoietin-like 2 is essential to aortic valve development in mice

Mice knockdown for Angiopoietin-like 2 (Angptl2) exhibit spontaneous aortic valve stenosis associated with a decrease in Notch signalling and an imbalance in cell apoptosis, senescence and proliferation during embryonic valve remodelling stage.

Pauline Labbé
Victoria Munoz Goyette
Éric Thorin
ResearchOpen Access21 Nov 2022
Communications Biology

Volume: 5, P: 1-18
Assessment of the predictive potential of cognitive scores from retinal images and retinal fundus metadata via deep learning using the CLSA database

Denis Corbin
Frédéric Lesage
ResearchOpen Access06 Apr 2022
Scientific Reports

Volume: 12, P: 1-12
Binding to RNA regulates Set1 function

Pierre Luciano
Jongcheol Jeon
Vincent Géli
ResearchOpen Access24 Oct 2017
Cell Discovery

Volume: 3, P: 1-19

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Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male mice

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

Cerebral tissue pO₂ response to treadmill exercise in awake mice

Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue

Clustering of Crohn's disease within affected sibships

Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

Alteration of functional connectivity despite preserved cerebral oxygenation during acute hypoxia

Compromised microvascular oxygen delivery increases brain tissue vulnerability with age

Evaluation of stenoses using AI video models applied to coronary angiography

The pulsatile brain, pulse pressure, cognition, and antihypertensive treatments in older adults: a functional NIRS study

Genetic refinement and physical mapping of a chromosome 16q candidate region for inflammatory bowel disease

High hydrostatic pressure is similar to Holder pasteurization in preserving donor milk antimicrobial activity

A simulation study investigating potential diffusion-based MRI signatures of microstrokes

Validation of red blood cell flux and velocity estimations based on optical coherence tomography intensity fluctuations

In Vivo Near-Infrared Fluorescence Imaging of Atherosclerosis Using Local Delivery of Novel Targeted Molecular Probes

Machine-learning for the prediction of one-year seizure recurrence based on routine electroencephalography

Angiopoietin-like 2 is essential to aortic valve development in mice

Assessment of the predictive potential of cognitive scores from retinal images and retinal fundus metadata via deep learning using the CLSA database

Binding to RNA regulates Set1 function

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