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Understanding and controlling morphogenesis is vital for biology and organoid technology. Here, the authors report an efficient biomechanical system to generate gut spheroids, and reveal instability-driven morphogenetic transitions with computational models.

Despite recent advances in organic optoelectronics development, integration of electronics and photonics in a chip remains a challenge. Here, the authors demonstrate organic field-effect optical waveguides that control propagating photons by the electric field produced in an organic transistor.

A single-cell transcriptomic analysis of 63 patients with colorectal cancer classifies tumor cells into two epithelial subtypes. An improved tumor classification based on epithelial subtype, microsatellite stability and fibrosis reveals differences in pathway activation and metastasis.

Constructing two-dimensional (2D) polymers with complex tessellation patterns is important for the fabrication of advanced materials but achieving such complexity is a great challenge. Here the authors report a tessellated 2D covalent organic framework with increased structural complexity as well as different pore structures.

Magnetohydrodynamic (MHD) waves observed on the Sun help understanding solar plasma and involved processes. Here, the authors show resolved MHD waves in the solar corona displaying MHD lensing effect.

Light-emitting diodes with suppressed efficiency roll-off can be created by intercalating oxygen plasma into few-layer molybdenum disulfide and tungsten disulfide.

Acorales is sister to all other monocots and contains only one family with just one genus, Acorus. Here, the authors assemble the genome of the diploid Ac. gramineus and the tetraploid Ac. calamus, reconstruct an ancestral monocot karyotype and gene toolkit, and discuss the origin and evolution of the two species and other monocots.

Coronavirus main protease is essential for viral polyprotein processing and maturation. Here Fu et al. report efficient inhibition of SARS-CoV-2 replication using two inhibitors - Boceprevir and GC376 - targeting the active site of the main viral protease.

Black phosphorus (BP) is a 2D semiconductor with potential for (opto-)electronic applications, but its large-scale integration with Si substrates is challenging. Here, the authors report a method to transfer cm-scale BP films onto SiO₂/Si substrates retaining their uniformity and electrical properties.

The crystal structure of iron under the extreme pressures and temperatures of Earth’s core is debated. Numerical simulations suggest that the body-centred cubic structure of iron is stable under inner-core conditions.

Understanding greenhouse gas (GHG) emission patterns in crop production, particularly their spatial and temporal distributions, is key to designing better policies. This study combines secondary data and household survey data to examine the GHG emissions intensity of croplands in China and how it has fluctuated in the past few decades and to identify the factors driving emissions intensity inequality.

Applying economic complexity methods, this study maps global progress toward the SDGs, uncovering distinct development paths and disparities among 166 countries. It highlights overlooked areas in sustainable development, offering insights into how nations can better achieve the SDGs.

A multivalent immobilization strategy uses hydrogen, ionic and coordination bonds that interact with perovskite, enabling deep-blue perovskite LEDs to achieve an external quantum efficiency of 15.36% at 459 nm.

A recombinant vaccine that targets the receptor-binding ___domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Polo-like kinase 3 (Plk3) has a tumor suppressive role through the induction of apoptosis, however, the mechanism underlying its activation is unclear. Here, in pancreatic cancer, the authors show that activation of Plk3 is dependent on its cleavage into p41Plk3, by the metalloendopeptidase nardilysin.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

Somatostatin receptor 2 (SSTR2) represents a therapeutic target of neuroendocrine tumors. Here, authors report two structures of SSTR2 bound to peptide octreotide and small molecule paltusotine, revealing the basis subtype selectivity and signal bias properties.

Derivation of human primordial germ cell-like cells (hPGCLCs) is critical for reproductive medicine. Here, authors report the induction of hPGCLCs in a bioengineered human pluripotent stem cell culture that mimics peri-implantation human development.

All-solid-state sodium-ion batteries are promising candidates for grid-scale energy storage, but they require superior solid-state electrolytes (SSEs). Here sodium-ion SSEs based on dual-anion frameworks of oxychloride are studied and found to show high ionic conductivity and electrochemical oxidative stability with mechanical softness.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Here, the authors present a multi-omic framework using single cell technology to identify non-coding genetic variants in cranial motor neuron disorders, offering insights into their genetic basis and methods for studying other Mendelian diseases.

Strain engineering is promising for improving catalytic capability of biocatalysts, but it is challenging to modify the atomic-scale strain for specific enzyme-like reactions. Here, the authors report the biocatalysts with atomically-resolved Pt clusters laminated on PdAu nanocrystals and show that the tensile strains contribute to the enzyme-like activities greater than that of natural enzymes.

Controlling the crystallization of perovskites is not trivial. Here Wang et al. develop a close-space annealing to improve the structural and optoelectronic quality of perovskite films with different chemical compositions, leading to over 25% efficiency in all-perovskite tandem solar cells.

Light-driven approaches could lower the carbon footprint of chemical production. Here the authors use the perovskite oxide LaMn_1−xCu_xO₃ as a photocatalyst to convert ethane to ethylene and hydrogen.

Artificial intelligence (AI)-based docking and scoring methods demonstrate considerable potential for virtual drug screening. Gu et al. go further by assessing the structural rationality of AI-predicted complex conformations from various sources.

Spatial gene expression provides insights into disease mechanisms. Here, authors benchmark eleven methods predicting spatial gene expression from histology images across five datasets and external validation, providing insights into clinical utility, challenges, and future directions.

This study presents an advanced ChIP-seq method, provides a valuable epigenomics resource for 14 economically important plant organs and reveals histone modification landscape dynamics and functions during rapeseed seed dormancy and germination.

The marine compound microcolin B stimulates the Hippo pathway and selectively kills YAP-dependent cancer cells by inhibiting phosphatidylinositol transfer protein and depleting plasma membrane phosphatidylinositol-4-phosphate.

ICI-induced myocarditis is fatal, but its mechanism is unclear. Here, the authors identify GSDME as a key driver by promoting cGAS-STING signaling, enhancing our understanding of its pathogenesis.

Yao and Gong et al. identify WD40 repeat-containing protein 6 (WDR6) to be upregulated in the liver of insulin-resistant mice. WDR6 contributes to promoting hepatic de novo lipogenesis during insulin resistance by upregulation of fatty acid synthase, and the authors identify a small molecule to inhibit this effect of WDR6 and reduce hepatic steatosis.

The authors induce a phase boundary similar to Pb(Zr, Ti)O₃’s morphotropic phase boundary structure in (K, Na)NbO₃-based ceramics, which exhibit high residual polarization as well as a significantly improved piezoelectric constant d₃₃.

Designing molecules in drug design is challenging as it requires optimizing multiple, potentially competing qualities. Wu and colleagues present a prompt-based molecule optimization method that can be trained from single-property data.

China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.

The authors identify an ideal thermoelectric barrier layer by exploiting distinct chemical reaction activities and diffusion behaviors during sintering and operation, achieving 11% module efficiency at 723 K with enhanced long-term stability.