INPP5E is shown to be involved in the process of proximal TCR signaling activation at the immune synapse by providing a preferable phosphoinositide microenvironment via hydrolyzing PI(4,5)P2 at the plasma membrane, regulating complex formation with CD3ζ, ZAP-70, and Lck, allowing proximal TCR signaling and T cell activation.
- Tzu-Yuan Chiu
- Chien-Hui Lo
- Won-Jing Wang